New England Biolabs
@nebiolabs.bsky.social
Developing innovative products for the life science industry and providing insightful technical support.
@liverpooluni.bsky.social and NEB researchers used Cappable-seq to observe differential expression in response to stressors in Wolbachia, providing insights for mosquito control. Learn more in Microbial Genomics: https://nebiolabs.com/3YPZ1X0
Cappable-Seq reveals the transcriptional landscape of stress responses in the bacterial endosymbiont Wolbachia
An erratum of this article has been published full details can be found at
https://doi.org/10.1099/mgen.0.001584
Bacterial endosymbionts are highly prevalent among invertebrate animals, in which they ...
www.microbiologyresearch.org
January 2, 2026 at 8:55 PM
@liverpooluni.bsky.social and NEB researchers used Cappable-seq to observe differential expression in response to stressors in Wolbachia, providing insights for mosquito control. Learn more in Microbial Genomics: https://nebiolabs.com/3YPZ1X0
Cornell University and NEB researchers used High-Complexity Golden Gate Assembly to develop an engineered bacteriophage biosensor that can detect E. coli in drinking water samples. Read more in American Chemical Society: https://pubs.acs.org/doi/10.1021/acssynbio.5c00665
Recoded Bacteriophage Genome for Bio-Orthogonal-Enabled Concentration and Detection of E. coli in Drinking Water
Modern genome editing methods permit the flexible modification of organisms at the genome level. However, bacteriophages, despite their small genomes, pose unique challenges due to the need to edit during their infection cycle, then select/screen for th...
pubs.acs.org
December 31, 2025 at 6:06 PM
Cornell University and NEB researchers used High-Complexity Golden Gate Assembly to develop an engineered bacteriophage biosensor that can detect E. coli in drinking water samples. Read more in American Chemical Society: https://pubs.acs.org/doi/10.1021/acssynbio.5c00665
In a new protocol, NEB researchers detail steps for preparing standard solutions, building calibration curves to identify and quantify RNA modifications by LC-MS/MS, and how to efficiently convert RNA to nucleosides and perform sample analysis. https://nebiolabs.com/4jbP7bw
Protocol for RNA modification analysis by UHPLC-QqQ MS
www.sciencedirect.com
December 26, 2025 at 8:57 PM
In a new protocol, NEB researchers detail steps for preparing standard solutions, building calibration curves to identify and quantify RNA modifications by LC-MS/MS, and how to efficiently convert RNA to nucleosides and perform sample analysis. https://nebiolabs.com/4jbP7bw
Like a snowflake, science is unique, intricate, and shaped by countless unseen forces. Thank you for your continued support, and may we continue to shape science together in 2026.
#shapingscience
#shapingscience
December 24, 2025 at 5:55 PM
Like a snowflake, science is unique, intricate, and shaped by countless unseen forces. Thank you for your continued support, and may we continue to shape science together in 2026.
#shapingscience
#shapingscience
Find your ideal total RNA isolation kit for higher throughput and prep needs with Monarch! The Monarch Spin RNA Isolation Kit (Mini) now offers a 200-prep size to meet your needs 🦋 https://nebiolabs.com/4p42BYp
Monarch® Spin RNA Isolation Kit (Mini) | NEB
New version of Monarch kit for total RNA purification and extraction from many samples including bacteria, yeast, plants, cells, tissue, blood, with unique high binding capacity and low elution volume...
nebiolabs.com
December 23, 2025 at 5:53 PM
Find your ideal total RNA isolation kit for higher throughput and prep needs with Monarch! The Monarch Spin RNA Isolation Kit (Mini) now offers a 200-prep size to meet your needs 🦋 https://nebiolabs.com/4p42BYp
Look forward to the upcoming year in science with 2026 predictions presented by @biocompare.bsky.social, including a highlight from NEB Executive Director of Research Tom Evans on clinical diagnostics! https://nebiolabs.com/491IaVQ
A Look Ahead: Predictions for the Life Sciences in 2026
Industry insiders share what’s on their radar for next year.
www.biocompare.com
December 19, 2025 at 8:57 PM
Look forward to the upcoming year in science with 2026 predictions presented by @biocompare.bsky.social, including a highlight from NEB Executive Director of Research Tom Evans on clinical diagnostics! https://nebiolabs.com/491IaVQ
Looking for highly pure E. coli tRNA for your cell-free protein synthesis or other research applications? Our newly released E. coli tRNA is isolated and purified without organic solvents, ensuring exceptional performance across diverse template sequences. https://nebiolabs.com/4aoMIrU
E. coli tRNA | NEB
E. coli tRNA is a mix of tRNAs isolated from E. coli and purified by chromatography. It sustains translation in E. coli-based in vitro protein synthesis reactions and is suited for molecular biology a...
nebiolabs.com
December 18, 2025 at 3:46 PM
Looking for highly pure E. coli tRNA for your cell-free protein synthesis or other research applications? Our newly released E. coli tRNA is isolated and purified without organic solvents, ensuring exceptional performance across diverse template sequences. https://nebiolabs.com/4aoMIrU
@mrclmb.bsky.social is #shapingscience by tackling fundamental research problems. In their Science article, Robertson et al. reengineered the genetic code of E. coli through total genome synthesis to create a 57-codon genome.
https://www.science.org/doi/10.1126/science.ady4368
https://www.science.org/doi/10.1126/science.ady4368
December 17, 2025 at 5:47 PM
@mrclmb.bsky.social is #shapingscience by tackling fundamental research problems. In their Science article, Robertson et al. reengineered the genetic code of E. coli through total genome synthesis to create a 57-codon genome.
https://www.science.org/doi/10.1126/science.ady4368
https://www.science.org/doi/10.1126/science.ady4368
Learn how RNA therapeutics move beyond their vaccine-based origins in a recent editorial by GEN featuring Nicole Nichols, Ph.D., NEB executive director of applications and product development: https://www.genengnews.com/topics/bioprocessing/beyond-vaccines-scaling-the-promise-of-rna-therapeutics/
Beyond Vaccines: Scaling the Promise of RNA Therapeutics
From enzymes and lipid nanoparticles to large-scale process design, four global innovators redefine RNA-based medicine development and delivery.
www.genengnews.com
December 16, 2025 at 6:39 PM
Learn how RNA therapeutics move beyond their vaccine-based origins in a recent editorial by GEN featuring Nicole Nichols, Ph.D., NEB executive director of applications and product development: https://www.genengnews.com/topics/bioprocessing/beyond-vaccines-scaling-the-promise-of-rna-therapeutics/
Durham University (@durham.ac.uk) and NEB scientists described the first biochemical characterization of GmrSD Type IV restriction enzyme substrate specificity and inhibition by phage protein IP1*. https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0072
Modified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxU
Abstract. Bacteriophages (phages), viral predators of bacteria, generate selection pressure that causes bacteria to evolve defence systems. Type I, II and
royalsocietypublishing.org
December 15, 2025 at 5:50 PM
Durham University (@durham.ac.uk) and NEB scientists described the first biochemical characterization of GmrSD Type IV restriction enzyme substrate specificity and inhibition by phage protein IP1*. https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0072
Only need to isolate a few RNA samples and looking to reduce unused reagents? The Monarch Spin RNA Isolation Kit (Mini) now comes in a convenient 10-prep size to suit your volume needs. https://nebiolabs.com/4pyQPpZ
Monarch® Spin RNA Isolation Kit (Mini) | NEB
New version of Monarch kit for total RNA purification and extraction from many samples including bacteria, yeast, plants, cells, tissue, blood, with unique high binding capacity and low elution volume...
nebiolabs.com
December 11, 2025 at 4:09 PM
Only need to isolate a few RNA samples and looking to reduce unused reagents? The Monarch Spin RNA Isolation Kit (Mini) now comes in a convenient 10-prep size to suit your volume needs. https://nebiolabs.com/4pyQPpZ
Science builds a greener, healthier & more compassionate world. The 2024 Passion in Science awards honored some “unsung heroes” of the lab, including 5 Science Mentorship & Advocacy Awardees #shapingscience by advocating for and mentoring scientists of tomorrow: https://nebiolabs.com/4oqEZwB
December 10, 2025 at 4:14 PM
Science builds a greener, healthier & more compassionate world. The 2024 Passion in Science awards honored some “unsung heroes” of the lab, including 5 Science Mentorship & Advocacy Awardees #shapingscience by advocating for and mentoring scientists of tomorrow: https://nebiolabs.com/4oqEZwB
Get a head start on organizing for 2026 by requesting a free copy of our upcoming calendar filled with beautiful photos from your fellow scientists: https://nebiolabs.com/3Y1Msaz
December 9, 2025 at 6:30 PM
Get a head start on organizing for 2026 by requesting a free copy of our upcoming calendar filled with beautiful photos from your fellow scientists: https://nebiolabs.com/3Y1Msaz
In collaboration with University College Cork and others, NEB scientists describe a long-running study of RM systems in Lactococcus species. Read more in Nucleic Acids Research: https://academic.oup.com/nar/article/53/17/gkaf854/8249855
Lactococcal mobile genetic elements harbour a diverse phage defensome rich in restriction-modification systems
Abstract. The genomes of 43 distinct lactococcal strains were reconstructed by a combination of long- and short-read sequencing, resolving the plasmid comp
academic.oup.com
December 9, 2025 at 5:24 PM
In collaboration with University College Cork and others, NEB scientists describe a long-running study of RM systems in Lactococcus species. Read more in Nucleic Acids Research: https://academic.oup.com/nar/article/53/17/gkaf854/8249855
In our latest podcast (https://nebiolabs.com/3KxkfoY), hear from Cynthia Ziwawo, M.D., Geoff Hutchinson, and Olubukola Abiona, whose collaborative work shaped the future of vaccines by developing the first COVID mRNA vaccine.
#shapingscience
#shapingscience
December 8, 2025 at 5:52 PM
In our latest podcast (https://nebiolabs.com/3KxkfoY), hear from Cynthia Ziwawo, M.D., Geoff Hutchinson, and Olubukola Abiona, whose collaborative work shaped the future of vaccines by developing the first COVID mRNA vaccine.
#shapingscience
#shapingscience
Ready for a streamlined PCR & #DNAcleanup option? Our new Monarch Mag PCR & DNA Cleanup Kit (5 μg) (https://nebiolabs.com/4rPTMnE) uses a bind/wash/elute workflow for ssDNA and dsDNA with automation-friendly magnetic beads to eliminate the need for centrifugation or vacuum-based processing. 🦋
December 4, 2025 at 4:55 PM
Ready for a streamlined PCR & #DNAcleanup option? Our new Monarch Mag PCR & DNA Cleanup Kit (5 μg) (https://nebiolabs.com/4rPTMnE) uses a bind/wash/elute workflow for ssDNA and dsDNA with automation-friendly magnetic beads to eliminate the need for centrifugation or vacuum-based processing. 🦋
Using a phage-inspired genetic screen and biochem, NEB, Harvard Medical School, and University of Illinois Urbana-Champaign researchers discovered OLD inactivates tRNAs by a completely novel mechanism: severing anticodon arms! https://nebiolabs.com/4rysTEk
#tRNA #PhageDefense
#tRNA #PhageDefense
OLD amputates the anticodon arm of tRNAs during P2–Lambda interference
Abstract. ATPase-coupled Toprim (Topoisomerase-primase) nucleases, known as Overcoming Lysogenization Defect (OLD) proteins, are crucial for diverse antiph
academic.oup.com
December 3, 2025 at 5:08 PM
Using a phage-inspired genetic screen and biochem, NEB, Harvard Medical School, and University of Illinois Urbana-Champaign researchers discovered OLD inactivates tRNAs by a completely novel mechanism: severing anticodon arms! https://nebiolabs.com/4rysTEk
#tRNA #PhageDefense
#tRNA #PhageDefense
With the NEBNext Flu A Integrated Indexing Primer Module (https://nebiolabs.com/4nSxUES), your Flu A cDNA synthesis & library prep is seamlessly compatible with the Monarch Mag Viral DNA/RNA Extraction Kit and LunaScript Multiplex One-Step RT-PCR Kit. Go from sample to sequence ready faster!
November 28, 2025 at 9:10 PM
With the NEBNext Flu A Integrated Indexing Primer Module (https://nebiolabs.com/4nSxUES), your Flu A cDNA synthesis & library prep is seamlessly compatible with the Monarch Mag Viral DNA/RNA Extraction Kit and LunaScript Multiplex One-Step RT-PCR Kit. Go from sample to sequence ready faster!
#SynBio is often limited by how quickly & affordably researchers can synthesize custom DNA. Learn more about a web tool & workflow NEB scientists developed, bypassing outsourced DNA & enabling labs to produce sequence-verified constructs in just 4 days at lower cost. https://nebiolabs.com/48auZBo
Building Genes Faster and Cheaper with Decentralized Workflows | NEB
A new decentralized DNA synthesis workflow from NEB delivers sequence-confirmed genes in 4 days, cutting costs 3–5x and accelerating discovery.
www.neb.com
November 21, 2025 at 9:15 PM
#SynBio is often limited by how quickly & affordably researchers can synthesize custom DNA. Learn more about a web tool & workflow NEB scientists developed, bypassing outsourced DNA & enabling labs to produce sequence-verified constructs in just 4 days at lower cost. https://nebiolabs.com/48auZBo
Sequencing Influenza A from wastewater samples can identify outbreaks before they impact the healthcare system. NEB teamed up with Ceres Nano to show how its NEBNext Flu A Integrated Indexing sequencing workflow could be enhanced with Nanotrap Microbiome A Particles https://nebiolabs.com/4i9KQVt
November 21, 2025 at 7:17 PM
Sequencing Influenza A from wastewater samples can identify outbreaks before they impact the healthcare system. NEB teamed up with Ceres Nano to show how its NEBNext Flu A Integrated Indexing sequencing workflow could be enhanced with Nanotrap Microbiome A Particles https://nebiolabs.com/4i9KQVt
Check out poster TT065 this morning at #AMPath2025, where Vaishnavi Panchapakesa, Ph. D. Will present on NEBNext enzymatic solutions for DNA methylation profiling of damaged DNA inputs!
November 15, 2025 at 1:30 PM
Check out poster TT065 this morning at #AMPath2025, where Vaishnavi Panchapakesa, Ph. D. Will present on NEBNext enzymatic solutions for DNA methylation profiling of damaged DNA inputs!
Stop by poster ST156 this morning at #AMPath2025 to learn about how integrating whole exome sequencing and RNA-seq can facilitate somatic mutation detection in tumor tissue samples, presented by Margaret R. Heider, Ph.D.!
November 14, 2025 at 1:30 PM
Stop by poster ST156 this morning at #AMPath2025 to learn about how integrating whole exome sequencing and RNA-seq can facilitate somatic mutation detection in tumor tissue samples, presented by Margaret R. Heider, Ph.D.!
Don’t miss poster TT054 at the #AMPath2025 poster session this morning to learn about high-throughput methyl-binding domain-based DNA enrichment and sequencing from Kaylinnette Pinet, Ph.D.!
November 14, 2025 at 1:30 PM
Don’t miss poster TT054 at the #AMPath2025 poster session this morning to learn about high-throughput methyl-binding domain-based DNA enrichment and sequencing from Kaylinnette Pinet, Ph.D.!
You may have noticed that - cough - #Influenza season is here. The NEBNext Flu A Integrated Indexing Primer Module is here to support infectious disease surveillance & #NGS. Whether you’re monitoring wastewater, raw milk or clinical samples, sequence with confidence! https://nebiolabs.com/4nSxUES
November 13, 2025 at 4:13 PM
You may have noticed that - cough - #Influenza season is here. The NEBNext Flu A Integrated Indexing Primer Module is here to support infectious disease surveillance & #NGS. Whether you’re monitoring wastewater, raw milk or clinical samples, sequence with confidence! https://nebiolabs.com/4nSxUES
Join NEB’s #AMPath2025 Innovation Spotlight session in Theater 1 at 4:25 pm today and learn from Nathan Tanner, Ph.D., how NEB is “Powering the Next Generation of Diagnostics with Enzyme Engineering and Design!”
November 13, 2025 at 3:45 PM
Join NEB’s #AMPath2025 Innovation Spotlight session in Theater 1 at 4:25 pm today and learn from Nathan Tanner, Ph.D., how NEB is “Powering the Next Generation of Diagnostics with Enzyme Engineering and Design!”