MS Bioworks
@msbioworks.bsky.social
We productized proteomics services and tranformed the field. Here to discuss all things proteomics and occasionally stir the pot :)
Early front runner for paper of the year
pubs.acs.org/doi/10.1021/...
Super interesting ML stuff for peptide fragmentation in the associated github.com/PayneLab/Pro...
#Proteomics #TeamMassSpec
pubs.acs.org/doi/10.1021/...
Super interesting ML stuff for peptide fragmentation in the associated github.com/PayneLab/Pro...
#Proteomics #TeamMassSpec
pubs.acs.org
January 14, 2026 at 7:16 PM
Early front runner for paper of the year
pubs.acs.org/doi/10.1021/...
Super interesting ML stuff for peptide fragmentation in the associated github.com/PayneLab/Pro...
#Proteomics #TeamMassSpec
pubs.acs.org/doi/10.1021/...
Super interesting ML stuff for peptide fragmentation in the associated github.com/PayneLab/Pro...
#Proteomics #TeamMassSpec
Speaking of #AgenticAI somebody made an #MCP server for the OpenTrons robot! We're going to have a crack with #N8N and an OT2. If anyone is interested let me know.
github.com/yerbymatey/o...
github.com/yerbymatey/o...
GitHub - yerbymatey/opentrons-mcp: mcp server for robot automation + api documentation
mcp server for robot automation + api documentation - yerbymatey/opentrons-mcp
github.com
January 13, 2026 at 8:15 PM
Speaking of #AgenticAI somebody made an #MCP server for the OpenTrons robot! We're going to have a crack with #N8N and an OT2. If anyone is interested let me know.
github.com/yerbymatey/o...
github.com/yerbymatey/o...
After about 250 million years of doing mass spec I can conclude that isotope patterns never get boring. They are just a beautiful solution to a problem. #TeamMassSpec
January 13, 2026 at 2:38 PM
After about 250 million years of doing mass spec I can conclude that isotope patterns never get boring. They are just a beautiful solution to a problem. #TeamMassSpec
Reposted by MS Bioworks
A lawsuit by Alzheimer’s disease drugmaker T3D Therapeutics accuses five South Florida testing sites of falsification of data and other fraud in a test of an experimental compound, T3D-959. https://scim.ag/3Lu2pDP
Alzheimer’s drug developers accuse clinical trial sites of faking data
T3D Therapeutics alleges that contract researchers delivered “medically impossible” results on its candidate drug
scim.ag
January 9, 2026 at 2:23 PM
A lawsuit by Alzheimer’s disease drugmaker T3D Therapeutics accuses five South Florida testing sites of falsification of data and other fraud in a test of an experimental compound, T3D-959. https://scim.ag/3Lu2pDP
Reposted by MS Bioworks
I’m running for Congress in NY-12, my home.
We have a demented, criminal president running the country like a mob operation—government by the boss, for the boss.
We need Democratic fighters who will defend the rule of law and deliver government by the people. Join us.
We have a demented, criminal president running the country like a mob operation—government by the boss, for the boss.
We need Democratic fighters who will defend the rule of law and deliver government by the people. Join us.
January 6, 2026 at 11:59 AM
I’m running for Congress in NY-12, my home.
We have a demented, criminal president running the country like a mob operation—government by the boss, for the boss.
We need Democratic fighters who will defend the rule of law and deliver government by the people. Join us.
We have a demented, criminal president running the country like a mob operation—government by the boss, for the boss.
We need Democratic fighters who will defend the rule of law and deliver government by the people. Join us.
Let's have a review of how your LC systems behaved over the holiday break. We'll go first, M-Class systems as usual solid as a rock. The Neo's... more scripts than Seinfeld!
January 5, 2026 at 8:59 PM
Let's have a review of how your LC systems behaved over the holiday break. We'll go first, M-Class systems as usual solid as a rock. The Neo's... more scripts than Seinfeld!
Reposted by MS Bioworks
Are you interested in a postdoctoral position? Do you have experience in mitochondrial biology and in vivo research? Please send me your CV!
January 5, 2026 at 1:25 PM
Are you interested in a postdoctoral position? Do you have experience in mitochondrial biology and in vivo research? Please send me your CV!
Haptenated MHC peptides are all the rage. Really nice example here. #Proteomics #TeamMassSpec
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy - Nature Communications
Covalent KRAS inhibitors show initial responses but resistance limits durability. Here drug-induced hapten peptides are identified and characterized, enabling production of high affinity, cross-HLA T ...
www.nature.com
December 21, 2025 at 5:50 PM
Haptenated MHC peptides are all the rage. Really nice example here. #Proteomics #TeamMassSpec
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Good reason to subscribe to @aaas.org @science.org I spotted this one while reading last night. Amazing bit of DNA cross-linking analysis www.science.org/doi/10.1126/...
Protein-Protein cross linking is going to a be an emerging force in 2026 for sure. #TeamMassSpec
Protein-Protein cross linking is going to a be an emerging force in 2026 for sure. #TeamMassSpec
December 18, 2025 at 2:54 PM
Good reason to subscribe to @aaas.org @science.org I spotted this one while reading last night. Amazing bit of DNA cross-linking analysis www.science.org/doi/10.1126/...
Protein-Protein cross linking is going to a be an emerging force in 2026 for sure. #TeamMassSpec
Protein-Protein cross linking is going to a be an emerging force in 2026 for sure. #TeamMassSpec
LOL!
Merriam-Webster’s human editors have chosen ‘slop’ as the 2025 Word of the Year.
December 15, 2025 at 5:27 PM
LOL!
Veo 3.1 2025
It's time to break out the AI folks :) Crank up the volume for this one!
December 15, 2025 at 5:12 PM
Veo 3.1 2025
Sora 2024!
Kicked the tires on Sora. Not bad for three sentences and a twenty second wait.
December 15, 2025 at 5:11 PM
Sora 2024!
It's time to break out the AI folks :) Crank up the volume for this one!
December 15, 2025 at 5:10 PM
It's time to break out the AI folks :) Crank up the volume for this one!
#Proteomics folks @thermofishersci.bsky.social is having a 3 for 2 Christmas sale that includes TMT reagents
www.thermofisher.com/us/en/home/p...
www.thermofisher.com/us/en/home/p...
3 for 2 Savings | Thermo Fisher Scientific - US
Buy 2 qualifying Thermo Fisher Scientific products and get the 3rd free. Enjoy 33% savings on research essentials through December 31.
www.thermofisher.com
December 9, 2025 at 1:47 PM
#Proteomics folks @thermofishersci.bsky.social is having a 3 for 2 Christmas sale that includes TMT reagents
www.thermofisher.com/us/en/home/p...
www.thermofisher.com/us/en/home/p...
Reposted by MS Bioworks
Know your rights. Protect your neighbors.
New York is — and always will be — a city for all immigrants.
New York is — and always will be — a city for all immigrants.
December 7, 2025 at 5:03 PM
Know your rights. Protect your neighbors.
New York is — and always will be — a city for all immigrants.
New York is — and always will be — a city for all immigrants.
Reposted by MS Bioworks
We are delighted to release 𝐃𝐈𝐀-𝐍𝐍 𝟐.𝟑.𝟏, with a groundbreaking 𝐈𝐧𝐟𝐢𝐧𝐃𝐈𝐀 module for fast searches against huge databases and support for 𝐃𝐃𝐀 data.
Release notes: github.com/vdemichev/Di...
Release notes: github.com/vdemichev/Di...
December 5, 2025 at 11:51 AM
We are delighted to release 𝐃𝐈𝐀-𝐍𝐍 𝟐.𝟑.𝟏, with a groundbreaking 𝐈𝐧𝐟𝐢𝐧𝐃𝐈𝐀 module for fast searches against huge databases and support for 𝐃𝐃𝐀 data.
Release notes: github.com/vdemichev/Di...
Release notes: github.com/vdemichev/Di...
Reposted by MS Bioworks
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
Cryo-electron microscopy ensemble optimization using individual particles and physical constraints
Biomolecules are inherently dynamic, and understanding their conformational ensemble distributions is essential for understanding their dynamics and biological roles. Cryo-electron microscopy (cryo-EM...
www.biorxiv.org
December 5, 2025 at 4:13 PM
Happy to share our cryoEM Ensemble Optimization method! 🎉It infers optimal structures and their weights directly from individual cryoEM images - no maps just physics! with David Sliva-Sánchez, @erikhthiede.bsky.social & Roy Lederman www.biorxiv.org/content/10.6...
Has anyone ever used Ardia and thought "mmm, that was a great experience"? #TotallyInfuriating
December 5, 2025 at 2:51 PM
Has anyone ever used Ardia and thought "mmm, that was a great experience"? #TotallyInfuriating
Microscopy-Guided Spatial Proteomics Reveals Novel Proteins at the Mitochondria-Lipid Droplet Interface and Their Role in Lipid Metabolism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Microscopy-Guided Spatial Proteomics Reveals Novel Proteins at the Mitochondria-Lipid Droplet Interface and Their Role in Lipid Metabolism
Mitochondria-lipid droplet (LD) interactions play a critical role in lipid metabolism and the progression of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). However, the dynamic ...
www.biorxiv.org
November 25, 2025 at 2:31 PM
Microscopy-Guided Spatial Proteomics Reveals Novel Proteins at the Mitochondria-Lipid Droplet Interface and Their Role in Lipid Metabolism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Stone Roses - Fools Gold (Official Video)
YouTube video by StoneRosesVEVO
www.youtube.com
November 20, 2025 at 8:17 PM
We lost a good one today folks. No Mani, no Fools Gold
#StoneRoses #LiveForever #Mani
www.bbc.com/news/article...
#StoneRoses #LiveForever #Mani
www.bbc.com/news/article...
Gary 'Mani' Mounfield: Stone Roses and Primal Scream bassist dies aged 63
The Stone Roses pay tribute to "our wonderful brother" Gary 'Mani' Mounfield after his death aged 63.
www.bbc.com
November 20, 2025 at 8:07 PM
We lost a good one today folks. No Mani, no Fools Gold
#StoneRoses #LiveForever #Mani
www.bbc.com/news/article...
#StoneRoses #LiveForever #Mani
www.bbc.com/news/article...
The Astral Zoom paper is here: www.biorxiv.org/content/10.1...
Bravo to @jesperolsenlab.bsky.social for this notable comment:
"Notably, for both DIA-NN and Spectronaut,
inference to protein-coding genes was done via gene names, to avoid inflation of identification
rates via isoforms.
Bravo to @jesperolsenlab.bsky.social for this notable comment:
"Notably, for both DIA-NN and Spectronaut,
inference to protein-coding genes was done via gene names, to avoid inflation of identification
rates via isoforms.
From HeLa to human blood: extending single-cell proteomics to the smallest immune cells
Single-cell proteomics (SCP) holds the promise of decoding cellular heterogeneity at the functional level, yet achieving deep and reproducible proteome coverage from individual cells has remained a fo...
www.biorxiv.org
November 13, 2025 at 11:07 PM
The Astral Zoom paper is here: www.biorxiv.org/content/10.1...
Bravo to @jesperolsenlab.bsky.social for this notable comment:
"Notably, for both DIA-NN and Spectronaut,
inference to protein-coding genes was done via gene names, to avoid inflation of identification
rates via isoforms.
Bravo to @jesperolsenlab.bsky.social for this notable comment:
"Notably, for both DIA-NN and Spectronaut,
inference to protein-coding genes was done via gene names, to avoid inflation of identification
rates via isoforms.
Reposted by MS Bioworks
The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database -- or you may be better off using TrEMBL.
www.matrixscience.com/blog/replace...
#proteomics #massspec
www.matrixscience.com/blog/replace...
#proteomics #massspec
Replacements for NCBI nr
www.matrixscience.com
November 10, 2025 at 2:46 PM
The NCBI nr FASTA file of protein sequences is no longer updated. We've summarised instructions for creating it from the BLAST database -- or you may be better off using TrEMBL.
www.matrixscience.com/blog/replace...
#proteomics #massspec
www.matrixscience.com/blog/replace...
#proteomics #massspec
Reposted by MS Bioworks
100 Python Projects — From Beginner to Expert
pythonclcoding.gumroad.com/l/100PythonP...
pythonclcoding.gumroad.com/l/100PythonP...
November 8, 2025 at 6:00 PM
100 Python Projects — From Beginner to Expert
pythonclcoding.gumroad.com/l/100PythonP...
pythonclcoding.gumroad.com/l/100PythonP...
Using @n8n.io a @Lego Buildhat for a @raspberrypi.com, an MCP server care of @anthropic.com and inspired by @jeffgeerling.com and @Networkchuck my son and I just made Agentic Lego!!! Tomorrow Art! MCP servers rule!
November 7, 2025 at 1:38 AM
Using @n8n.io a @Lego Buildhat for a @raspberrypi.com, an MCP server care of @anthropic.com and inspired by @jeffgeerling.com and @Networkchuck my son and I just made Agentic Lego!!! Tomorrow Art! MCP servers rule!