michaelpacold.bsky.social
@michaelpacold.bsky.social
Out now:

rdcu.be/evxCv

We've used CoQ10 headgroup intermediates to treat mouse models of a mitochondrial disease and improve the neurological symptoms of a patient with this disease.

Grateful for funding from @damonrunyon.org , Pershing Square Foundation, @americancancersoc.bsky.social, NIH!
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature
Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...
www.nature.com
July 9, 2025 at 5:32 PM