Michael Kugler
@michaelkugler.bsky.social
Postdoctoral researcher | Hopfner lab | Gene Center #StructuralBiology #CryoEM #InnateImmunity
Pinned
Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and Katja Lammens in @hopfnerlab.bsky.social at @genecenter-lmu.bsky.social. Now online at @naturecomms.bsky.social.
Reposted by Michael Kugler
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
September 18, 2025 at 4:09 PM
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
Reposted by Michael Kugler
Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1
November 22, 2024 at 8:10 AM
Laser Flash Melting Cryo-EM Samples to Overcome Preferred Orientation biorxiv.org/cgi/content/short/2024.11.21.624652v1
Reposted by Michael Kugler
Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...
www.biorxiv.org
March 17, 2025 at 9:43 AM
Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
Reposted by Michael Kugler
Join us in our next #MunichRNA19F!
📍 @mpibiochem.bsky.social
📅 19/02/2025
We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian.
Don't miss it! 🧬😀
📍 @mpibiochem.bsky.social
📅 19/02/2025
We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian.
Don't miss it! 🧬😀
January 29, 2025 at 12:00 PM
Join us in our next #MunichRNA19F!
📍 @mpibiochem.bsky.social
📅 19/02/2025
We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian.
Don't miss it! 🧬😀
📍 @mpibiochem.bsky.social
📅 19/02/2025
We will hear amazing talks from Shuyao Sha (@kusterlab.bsky.social), @lauradmartens.bsky.social (@gagneurlab.bsky.social), @michaelkugler.bsky.social (@hopfnerlab.bsky.social), Marc Schmitt-Supprian.
Don't miss it! 🧬😀
Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and Katja Lammens in @hopfnerlab.bsky.social at @genecenter-lmu.bsky.social. Now online at @naturecomms.bsky.social.
Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
December 3, 2024 at 8:01 PM
Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and Katja Lammens in @hopfnerlab.bsky.social at @genecenter-lmu.bsky.social. Now online at @naturecomms.bsky.social.