Matilde Florean
@matildeflorean.bsky.social
🌱 enzymes and pseudoenzymes, evolution of natural products. PhD student at MPI for chemical ecology.
Pinned
Highjacked by a pseudoenzyme: How eudicot plants make indole
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
The working dead 🧟♀️: not just a metaphor for PhD students but also an enzymatic strategy!
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social
Reposted by Matilde Florean
All good things must come to an end... and apparently, all BAHD ones too! 😅
Check out our latest preprint on bioRxiv: www.biorxiv.org/content/10.1...
Thanks to the great team at @oconnorlab.bsky.social, @mpi-ce.bsky.social, and our collaborators at Uni York — couldn't have done it without you all!
Check out our latest preprint on bioRxiv: www.biorxiv.org/content/10.1...
Thanks to the great team at @oconnorlab.bsky.social, @mpi-ce.bsky.social, and our collaborators at Uni York — couldn't have done it without you all!
BAHD news from Euphorbia peplus: identification of acyltransferase enzymes involved in ingenane diterpenoid biosynthesis
The plant family Euphorbiaceae are an abundant source of structurally complex diterpenoids, many of which have reported anti-cancer, anti-HIV, and anti-inflammatory activities. Among these, ingenol-3-...
www.biorxiv.org
March 18, 2025 at 7:49 AM
All good things must come to an end... and apparently, all BAHD ones too! 😅
Check out our latest preprint on bioRxiv: www.biorxiv.org/content/10.1...
Thanks to the great team at @oconnorlab.bsky.social, @mpi-ce.bsky.social, and our collaborators at Uni York — couldn't have done it without you all!
Check out our latest preprint on bioRxiv: www.biorxiv.org/content/10.1...
Thanks to the great team at @oconnorlab.bsky.social, @mpi-ce.bsky.social, and our collaborators at Uni York — couldn't have done it without you all!
Reposted by Matilde Florean
Very pleased to announce that our manuscript describing @jgi.doe.gov 's Secondary Metabolism Collaboratory is now available! SMC has been up and active for a while now, but I'm really excited to start seeing more activity on here. Lots more to come.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
The secondary metabolism collaboratory: a database and web discussion portal for secondary metabolite biosynthetic gene clusters
Abstract. Secondary metabolites are small molecules produced by all corners of life, often with specialized bioactive functions with clinical and environme
doi.org
November 14, 2024 at 5:31 PM
Very pleased to announce that our manuscript describing @jgi.doe.gov 's Secondary Metabolism Collaboratory is now available! SMC has been up and active for a while now, but I'm really excited to start seeing more activity on here. Lots more to come.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Matilde Florean
Our Taxol pathway preprint!
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
www.biorxiv.org
November 13, 2024 at 5:24 PM
Our Taxol pathway preprint!
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor.
Biggest surprise: a new protein that helps our oxidases produce the correct product
The working dead 🧟♀️: not just a metaphor for PhD students but also an enzymatic strategy!
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social
Highjacked by a pseudoenzyme: How eudicot plants make indole
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 27, 2024 at 10:46 AM
The working dead 🧟♀️: not just a metaphor for PhD students but also an enzymatic strategy!
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social
If you are curious how a pseudoenzyme (aka the “dead” version of an enzyme) produces indole in plants 🌱check out our preprint: www.biorxiv.org/content/10.1...
#PlantBiology#natprod @oconnorlab.bsky.social