markmcan.bsky.social
@markmcan.bsky.social
The Charity Engine guy. Over 1.5 billion CPU-hours donated to science and medicine so far www.charityengine.com/grants
Pinned
The Power of Charity for Protein Design - Institute for Protein Design
August 15, 2014 In this post we explore the power of charity to supply the massive computing capacity needed to support our protein design research. As shown in Figure 1, thanks to hundreds of thousan...
www.ipd.uw.edu
Ten years ago, Charity Engine began donating computing time - over 200 million hours so far - to the Institute for Protein Design's brilliant Rosetta @ Home project.
Its founder, David Baker, won the 2024 Nobel Prize for Chemistry.
Beyond proud to be a supporter! www.ipd.uw.edu/news-pages/t...
Its founder, David Baker, won the 2024 Nobel Prize for Chemistry.
Beyond proud to be a supporter! www.ipd.uw.edu/news-pages/t...
Holy crap.
Wait until you read the lyrics of one particular song that Nigel Farage used to sing at Dulwich college.
This should be the end of him
Wait until you read the lyrics of one particular song that Nigel Farage used to sing at Dulwich college.
This should be the end of him
December 27, 2025 at 9:58 AM
Holy crap.
Wait until you read the lyrics of one particular song that Nigel Farage used to sing at Dulwich college.
This should be the end of him
Wait until you read the lyrics of one particular song that Nigel Farage used to sing at Dulwich college.
This should be the end of him
Reposted by markmcan.bsky.social
The White House has been caught.
The administration inserted a photo of Bill Clinton, Michael Jackson, and Diana Ross into the Epstein files and falsely implied it showed them with victims.
In reality, it’s a publicly available fundraiser photo featuring Jackson and Ross’s own children.
The administration inserted a photo of Bill Clinton, Michael Jackson, and Diana Ross into the Epstein files and falsely implied it showed them with victims.
In reality, it’s a publicly available fundraiser photo featuring Jackson and Ross’s own children.
December 20, 2025 at 12:33 PM
The White House has been caught.
The administration inserted a photo of Bill Clinton, Michael Jackson, and Diana Ross into the Epstein files and falsely implied it showed them with victims.
In reality, it’s a publicly available fundraiser photo featuring Jackson and Ross’s own children.
The administration inserted a photo of Bill Clinton, Michael Jackson, and Diana Ross into the Epstein files and falsely implied it showed them with victims.
In reality, it’s a publicly available fundraiser photo featuring Jackson and Ross’s own children.
Reposted by markmcan.bsky.social
My son Rory died suddenly in August. He was a wonderful boy: outward looking, funny & kind. He used to help homeless people so a local charity have set up “Rory’s gift” in his name. He would have been 19 today, if you’d like to make an internet stranger happy please consider donating, however small.
Rory's Gift
Rory was an incredibly kind and thoughtful young man. He would very often stop to give food to local people who were experiencing homelessness.
In memory of his life, we have set up 'Rory's Gift', an...
www.justgiving.com
December 19, 2025 at 6:55 AM
My son Rory died suddenly in August. He was a wonderful boy: outward looking, funny & kind. He used to help homeless people so a local charity have set up “Rory’s gift” in his name. He would have been 19 today, if you’d like to make an internet stranger happy please consider donating, however small.
“.. The Trump administration has transformed the release of the Epstein files into the 2025 version of WikiLeaks: a slow-drip document dump that could threaten a long list of Washington power players.”
@politico.com
www.politico.com/news/2025/12...
@politico.com
www.politico.com/news/2025/12...
December 20, 2025 at 1:15 PM
The sole "brexit benefit" is the complete and utter humiliation of its architects
In which Tim Stanley experiences the "find out" phase of his arrant fuck wittering.
December 20, 2025 at 12:59 PM
The sole "brexit benefit" is the complete and utter humiliation of its architects
I'm a Brit and this is bloody hilarious
December 19, 2025 at 12:20 PM
I'm a Brit and this is bloody hilarious
Is there any other country on Earth that would even consider this?
Axis of Evil has a new MVP
Axis of Evil has a new MVP
December 16, 2025 at 11:26 PM
Is there any other country on Earth that would even consider this?
Axis of Evil has a new MVP
Axis of Evil has a new MVP
With allies like Trump, who needs enemies
Only took three months for the US to weaponize the US-UK Tech deal: "British officials on Monday confirmed the US suspended the deal last week, with one saying the Trump administration was pushing for UK concessions in areas of trade outside the tech partnership."
www.ft.com/content/afd4...
www.ft.com/content/afd4...
US suspends technology deal with the UK
Washington pushes for concessions from London on the broader trade relationship
www.ft.com
December 16, 2025 at 5:35 PM
With allies like Trump, who needs enemies
Reposted by markmcan.bsky.social
Imagine it’s 2013 and you see this document from the UK sent back from the future. You’ll assume something went very wrong in that timeline.
December 16, 2025 at 2:21 PM
Imagine it’s 2013 and you see this document from the UK sent back from the future. You’ll assume something went very wrong in that timeline.
Reposted by markmcan.bsky.social
The only person with genuine Trump Derangement Syndrome is Trump himself
a woman in a leopard print jacket is talking into a microphone with the words it 's all about me youtube originals below her
Alt: a woman in a leopard print jacket is talking into a microphone with the words it 's all about me youtube originals below her
media.tenor.com
December 15, 2025 at 7:27 PM
The only person with genuine Trump Derangement Syndrome is Trump himself
Also quite fitting that not one of them is listening to anyone else
I guess it's fitting that it's a reimagined, worse version of someone else's artwork
December 12, 2025 at 6:13 AM
Also quite fitting that not one of them is listening to anyone else
TODDLERS being forced to act as their own attorneys in US immigration courts.
America is run by monsters.
UK should end the special relationship and rejoin the EU as soon as possible
America is run by monsters.
UK should end the special relationship and rejoin the EU as soon as possible
The fact that this scene is playing throughout America, thanks to the absolute criminal behavior of this regime, should be a gut punch to everyone. This cannot be allowed to continue.
What have we become? 😢
What have we become? 😢
December 11, 2025 at 12:32 PM
TODDLERS being forced to act as their own attorneys in US immigration courts.
America is run by monsters.
UK should end the special relationship and rejoin the EU as soon as possible
America is run by monsters.
UK should end the special relationship and rejoin the EU as soon as possible
More deal-breakers for data centres in space (😅):
1. Solar/cosmic radiation
They'd need to be specially hardened, with insane redundancy and fault tolerance, multiplying costs by 10x or more
2. Moore's Law
Servers and chips are obsolete within 3 years. Try upgrading in orbit
Beyond stupid idea
1. Solar/cosmic radiation
They'd need to be specially hardened, with insane redundancy and fault tolerance, multiplying costs by 10x or more
2. Moore's Law
Servers and chips are obsolete within 3 years. Try upgrading in orbit
Beyond stupid idea
I've seen this idea floated around and it's so fundamentally wrong that any professional suggesting it can be dismissed out of hand on anything they say.
Just because it's being passed around a lot: NO, data centers in space do NOT benefit from space being cold. Space is cold in the formal sense we use to define temperature. But it is very bad at cooling. What would you rather have to cool hot metal: a lukewarm water tub or a giant cold atmosphere?
December 11, 2025 at 2:15 AM
More deal-breakers for data centres in space (😅):
1. Solar/cosmic radiation
They'd need to be specially hardened, with insane redundancy and fault tolerance, multiplying costs by 10x or more
2. Moore's Law
Servers and chips are obsolete within 3 years. Try upgrading in orbit
Beyond stupid idea
1. Solar/cosmic radiation
They'd need to be specially hardened, with insane redundancy and fault tolerance, multiplying costs by 10x or more
2. Moore's Law
Servers and chips are obsolete within 3 years. Try upgrading in orbit
Beyond stupid idea
When he dies, and all his victims and evidence can finally be revealed without fear of death threats, Trump will go down in history as worse than Epstein
Trump in EJean Carroll deposition claiming she "loved it"
December 11, 2025 at 1:35 AM
When he dies, and all his victims and evidence can finally be revealed without fear of death threats, Trump will go down in history as worse than Epstein
Reposted by markmcan.bsky.social
In 1844 she hoped to "bequeath to the generations a Calculus of the Nervous System."
Celebrating Ada Lovelace's birth 210 years ago today with @stephenwolfram.bsky.social's essay on her life:
https://wolfr.am/1AuODbNPF
#Ada #AdaLovelace #FirstProgrammer #WomenInSTEM #ComputerScience
Celebrating Ada Lovelace's birth 210 years ago today with @stephenwolfram.bsky.social's essay on her life:
https://wolfr.am/1AuODbNPF
#Ada #AdaLovelace #FirstProgrammer #WomenInSTEM #ComputerScience
December 10, 2025 at 5:35 PM
In 1844 she hoped to "bequeath to the generations a Calculus of the Nervous System."
Celebrating Ada Lovelace's birth 210 years ago today with @stephenwolfram.bsky.social's essay on her life:
https://wolfr.am/1AuODbNPF
#Ada #AdaLovelace #FirstProgrammer #WomenInSTEM #ComputerScience
Celebrating Ada Lovelace's birth 210 years ago today with @stephenwolfram.bsky.social's essay on her life:
https://wolfr.am/1AuODbNPF
#Ada #AdaLovelace #FirstProgrammer #WomenInSTEM #ComputerScience
Concerning 😆
can't stop watching this clip of a tesla Optimus teleoperator taking his headset off before properly logging out the robot
December 9, 2025 at 6:51 AM
Concerning 😆
Reposted by markmcan.bsky.social
The LHC’s best 2025 discovery points the way to new physics
One key ingredient, needed to make more matter than antimatter, is CP-violation.
From 1964-2025, it had only ever been observed in mesons.
Well, meet our first CP-violating baryons!
bigthink.com/starts-with-...
#physics #matter #2025
One key ingredient, needed to make more matter than antimatter, is CP-violation.
From 1964-2025, it had only ever been observed in mesons.
Well, meet our first CP-violating baryons!
bigthink.com/starts-with-...
#physics #matter #2025
The LHC's best 2025 discovery points the way to new physics
Some vital, key ingredients must be in place for the Universe to make more matter than antimatter. The LHC took us one step closer in 2025.
bigthink.com
December 8, 2025 at 4:53 PM
The LHC’s best 2025 discovery points the way to new physics
One key ingredient, needed to make more matter than antimatter, is CP-violation.
From 1964-2025, it had only ever been observed in mesons.
Well, meet our first CP-violating baryons!
bigthink.com/starts-with-...
#physics #matter #2025
One key ingredient, needed to make more matter than antimatter, is CP-violation.
From 1964-2025, it had only ever been observed in mesons.
Well, meet our first CP-violating baryons!
bigthink.com/starts-with-...
#physics #matter #2025
Reposted by markmcan.bsky.social
Spotify is garbage on every count: Its treatment of artists, its ICE advertising, the CEO's investment in military AI, its leading role in the commodification and AI slopification of music, its terrible audio quality—you name it.
So I quit, and put together a complete guide to getting off Spotify:
So I quit, and put together a complete guide to getting off Spotify:
How to quit Spotify
This Black Friday, here's a guide to finding the best Spotify alternative
www.bloodinthemachine.com
December 3, 2025 at 12:09 AM
Spotify is garbage on every count: Its treatment of artists, its ICE advertising, the CEO's investment in military AI, its leading role in the commodification and AI slopification of music, its terrible audio quality—you name it.
So I quit, and put together a complete guide to getting off Spotify:
So I quit, and put together a complete guide to getting off Spotify:
"Reader, I MARRIED hepatitis..."
December 7, 2025 at 2:26 PM
"Reader, I MARRIED hepatitis..."
UK Bluesky you need this thread more than you can possibly imagine
December 7, 2025 at 2:06 PM
UK Bluesky you need this thread more than you can possibly imagine
Reposted by markmcan.bsky.social
My dad abhors any negative comments about immigrants. Asked him recently why he’s so strong on it: ‘Because we’re always happy to take the rich and clever ones. Which means it’s not about disliking immigrants. It’s about disliking the poor and vulnerable. And that’s a bad human instinct.’
December 7, 2025 at 8:31 AM
My dad abhors any negative comments about immigrants. Asked him recently why he’s so strong on it: ‘Because we’re always happy to take the rich and clever ones. Which means it’s not about disliking immigrants. It’s about disliking the poor and vulnerable. And that’s a bad human instinct.’
The USA is now a corrupt, incompetent, openly fascist regime that is constantly attacking the UK and our friends whilst helping our enemies.
Time to end the special relationship. America is lost
Time to end the special relationship. America is lost
December 7, 2025 at 1:38 PM
The USA is now a corrupt, incompetent, openly fascist regime that is constantly attacking the UK and our friends whilst helping our enemies.
Time to end the special relationship. America is lost
Time to end the special relationship. America is lost
Reposted by markmcan.bsky.social
New optics blog post: Infinite singularities in an optical beam??? 🧪 skullsinthestars.com/2025/12/06/i...
Infinite singularities in an optical beam???
Working on the second edition of my Singular Optics textbook and thought I would blog about some of the fun developments in the field that I’ve come across while doing the book research! Ligh…
skullsinthestars.com
December 6, 2025 at 3:52 PM
New optics blog post: Infinite singularities in an optical beam??? 🧪 skullsinthestars.com/2025/12/06/i...