Marketa Novotna
@marketanovotna.bsky.social
Interested in kinetoplastids | Genetics enthusiast | Postdoc in David Horn's group
Reposted by Marketa Novotna
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
November 4, 2025 at 11:45 AM
Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications.
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Join us at 12 noon on Thursday 14th November!
Register at docs.google.com/forms/d/e/1F...
Another piece of the VSG expression control puzzle: Active VSG transcript is required for allelic exclusion, acting as both, non-coding and coding RNA. Shout out to Douglas Escrivani and the team!
academic.oup.com/nar/article/53/19/gkaf1011/8294349
academic.oup.com/nar/article/53/19/gkaf1011/8294349
A non-coding role for trypanosome VSG transcripts in allelic exclusion
Abstract. Bloodstream-form African trypanosomes display antigenic variation. This requires mono-telomeric but switchable expression of a Variant Surface Gl
academic.oup.com
October 24, 2025 at 2:07 PM
Another piece of the VSG expression control puzzle: Active VSG transcript is required for allelic exclusion, acting as both, non-coding and coding RNA. Shout out to Douglas Escrivani and the team!
academic.oup.com/nar/article/53/19/gkaf1011/8294349
academic.oup.com/nar/article/53/19/gkaf1011/8294349
Reposted by Marketa Novotna
#Chagas disease remains very neglected, and not only in the US, in spite of an estimated 8 million people being infected with T. cruzi. We, and our collaborators, aim to develop new medicines, but this is becoming increasingly challenging due to lack of funding.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
‘Kissing bug’ disease should be treated as endemic in US, scientists say
People in at least eight states have been infected with Chagas, new report says, amid low awareness of disease
www.theguardian.com
September 16, 2025 at 11:48 AM
#Chagas disease remains very neglected, and not only in the US, in spite of an estimated 8 million people being infected with T. cruzi. We, and our collaborators, aim to develop new medicines, but this is becoming increasingly challenging due to lack of funding.
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
Save the date and join us on 22nd of August for a parasitology journal club, 1st session of the SPPIRIT Forum series.
We would like to invite you to join our brand new SPPIRIT Forum! This series of online meetings aims to bring parasitologists together to discuss science, funding opportunities, etc.
For more info, join our mailing list: tinyurl.com/3j5ewezv
For more info, join our mailing list: tinyurl.com/3j5ewezv
The SPPIRIT Forum
SPPIRIT would like to invite you to join our series of meetings - the SPPIRIT Forum!
The forum is a platform where we will discuss parasitology, funding applications, experimental methods, and other t...
tinyurl.com
July 31, 2025 at 6:42 PM
Save the date and join us on 22nd of August for a parasitology journal club, 1st session of the SPPIRIT Forum series.
Reposted by Marketa Novotna
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 5, 2025 at 9:08 AM
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 6, 2025 at 3:36 PM
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Marketa Novotna
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
www.biorxiv.org
May 27, 2025 at 10:28 AM
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
Reposted by Marketa Novotna
If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at @moredunfoundation.bsky.social Frank Katzer, @geordieparasit.bsky.social and EMs by @lemgruber.bsky.social www.biorxiv.org/content/10.1...
Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models
Cryptosporidium is an apicomplexan parasite that causes diarrhoeal disease. The species C. parvum is zoonotic and causes significant morbidity and mortality for both humans and farm animals; most comm...
www.biorxiv.org
May 7, 2025 at 11:09 AM
If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at @moredunfoundation.bsky.social Frank Katzer, @geordieparasit.bsky.social and EMs by @lemgruber.bsky.social www.biorxiv.org/content/10.1...
I am delighted that the preprint of my PhD work is out! We used Cas9-based method to edit essential polycistronic histone H4 gene in T. brucei for the first time. A big thanks to @fariatrypslab.bsky.social who was a fantastic mentor during my PhD
www.biorxiv.org/content/10.1...
#tbrucei #epigenetics
www.biorxiv.org/content/10.1...
#tbrucei #epigenetics
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...
www.biorxiv.org
March 26, 2025 at 11:49 AM
I am delighted that the preprint of my PhD work is out! We used Cas9-based method to edit essential polycistronic histone H4 gene in T. brucei for the first time. A big thanks to @fariatrypslab.bsky.social who was a fantastic mentor during my PhD
www.biorxiv.org/content/10.1...
#tbrucei #epigenetics
www.biorxiv.org/content/10.1...
#tbrucei #epigenetics
Reposted by Marketa Novotna
Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University on FindAPhD.com
PhD Project - Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University, listed on FindAPhD.com
www.findaphd.com
March 17, 2025 at 10:50 AM
Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Marketa Novotna
Happy to announce that we are running the third edition of the EMBL-UNESCO residency on infection biology. If you are an African female scientist and would like to do a research stay at EMBL, my lab is a possible hosting group.
Deadline March 31st!
www.embl.org/about/info/s...
Deadline March 31st!
www.embl.org/about/info/s...
February 19, 2025 at 6:20 PM
Happy to announce that we are running the third edition of the EMBL-UNESCO residency on infection biology. If you are an African female scientist and would like to do a research stay at EMBL, my lab is a possible hosting group.
Deadline March 31st!
www.embl.org/about/info/s...
Deadline March 31st!
www.embl.org/about/info/s...
Reposted by Marketa Novotna
🧵 🙌🏾 Congratulations #Guinea for eliminating sleeping sickness (gambiense form) as a public health problem in the country!
bit.ly/3Cgp0zq
1/3
bit.ly/3Cgp0zq
1/3
January 29, 2025 at 8:56 PM
🧵 🙌🏾 Congratulations #Guinea for eliminating sleeping sickness (gambiense form) as a public health problem in the country!
bit.ly/3Cgp0zq
1/3
bit.ly/3Cgp0zq
1/3
Reposted by Marketa Novotna
Our Jan issue highlights @sppirit-network.bsky.social connecting #Scottish #parasitology #ECRs, written by R. Edgar @jackhanna.bsky.social @marketanovotna.bsky.social @martacampillo.bsky.social @mukul1190.bsky.social @shikhas.bsky.social @vfrank.bsky.social & M.Ridgway
www.cell.com/trends/paras...
www.cell.com/trends/paras...
January 26, 2025 at 9:47 AM
Our Jan issue highlights @sppirit-network.bsky.social connecting #Scottish #parasitology #ECRs, written by R. Edgar @jackhanna.bsky.social @marketanovotna.bsky.social @martacampillo.bsky.social @mukul1190.bsky.social @shikhas.bsky.social @vfrank.bsky.social & M.Ridgway
www.cell.com/trends/paras...
www.cell.com/trends/paras...
Reposted by Marketa Novotna
🥁🥁 Job alertttt!! Interested in weird biology of malaria parasites? Inducible genetic screens? Single-cell RNAseq? Come postdoc with us - www.parafugelab.com ! International applicants or applicants just finishing up their PhD, both welcome!!
www.jobs.gla.ac.uk/job/research...
www.jobs.gla.ac.uk/job/research...
Research Assistant/Associate
Job Purpose We are seeking to recruit a motivated and creative Research Assistant/Associate (postdoctoral researcher) to work within an MRC-funded research programme https://gtr.ukri.org/projects?...
www.jobs.gla.ac.uk
January 17, 2025 at 11:50 AM
🥁🥁 Job alertttt!! Interested in weird biology of malaria parasites? Inducible genetic screens? Single-cell RNAseq? Come postdoc with us - www.parafugelab.com ! International applicants or applicants just finishing up their PhD, both welcome!!
www.jobs.gla.ac.uk/job/research...
www.jobs.gla.ac.uk/job/research...
Reposted by Marketa Novotna
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
January 13, 2025 at 8:28 PM
Have you finished your #PhD and are interested in exploring how #parasites cross the vasculature to colonize tissues? Do you fancy catching some #waves in the Atlantic? Or eating grilled fish by the beach?
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
Join us in #Lisbon at GIMM, where science meets quality of life.
@parasitesrule.bsky.social
If you are looking for a postdoc in tryps, check out this recent vacancy in the Faria lab in York. Great opportunity to work with a supportive mentor using cutting-edge techniques to address exciting questions.
Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York!
Please share!
jobs.york.ac.uk/vacancy/post...
Please share!
jobs.york.ac.uk/vacancy/post...
January 25, 2025 at 5:07 PM
If you are looking for a postdoc in tryps, check out this recent vacancy in the Faria lab in York. Great opportunity to work with a supportive mentor using cutting-edge techniques to address exciting questions.
If you are a budding parasitologist and you would like to spend a great summer full of science, networking, and fun with your peers, there is still time to apply for Biology of Parasitism course at @mblscience.bsky.social! Deadline 29th of January.
tinyurl.com/applyBoP
tinyurl.com/applyBoP
Biology of Parasitism: Modern Approaches | Marine Biological Laboratory
A unique course for advanced graduate students, postdocs, and independent investigators, who are seeking in-depth training in modern approaches to the study of protozoan parasites and parasitic worms.
www.mbl.edu
January 9, 2025 at 4:11 PM
If you are a budding parasitologist and you would like to spend a great summer full of science, networking, and fun with your peers, there is still time to apply for Biology of Parasitism course at @mblscience.bsky.social! Deadline 29th of January.
tinyurl.com/applyBoP
tinyurl.com/applyBoP
Have you heard of SPPIRIT (@sppirit-network.bsky.social)? In this article we explain how this ECR-led network of Scottish parasitologists was established, what impact it has already had and where it is heading!
www.cell.com/trends/paras...
www.cell.com/trends/paras...
January 9, 2025 at 4:01 PM
Have you heard of SPPIRIT (@sppirit-network.bsky.social)? In this article we explain how this ECR-led network of Scottish parasitologists was established, what impact it has already had and where it is heading!
www.cell.com/trends/paras...
www.cell.com/trends/paras...