Madeleine Hart
@madelouhart.bsky.social
Postdoc @VAInstitute studying mito metabolism and cell fate | PhD from the Sullivan Lab @FredHutch | mandolin player and scuba diver | @Beloit_College alum
Thank you for this awesome preLight!! Looking forward to sharing some more answers in our revised manuscript 🤩
Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis - preLights
Not all aspartate limitation is created equal: An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from oth...
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May 26, 2025 at 7:58 PM
Thank you for this awesome preLight!! Looking forward to sharing some more answers in our revised manuscript 🤩
Reposted by Madeleine Hart
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis https://www.biorxiv.org/content/10.1101/2025.02.18.638948v1
February 20, 2025 at 10:25 PM
Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!
Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.
Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!