Luke O’Shea
@lukeoshea.bsky.social
Director of Innovation, University College London Hospitals. Views my own
Lest we forget the greatest global challenge we all are facing...
🌍 Berkeley Earth’s 2025 Global Temperature Report is out.
2025 was the 3rd warmest year on record. Annual global temperature reached 1.44 ± 0.09°C above the pre-industrial baseline; 770 million people experienced locally record-warm annual conditions.
Full report: berkeleyearth.org/global-tempe...
2025 was the 3rd warmest year on record. Annual global temperature reached 1.44 ± 0.09°C above the pre-industrial baseline; 770 million people experienced locally record-warm annual conditions.
Full report: berkeleyearth.org/global-tempe...
Global Temperature Report for 2025 - Berkeley Earth
2025 was the 3rd warmest year on Earth since direct observations began, and recent warming appears to be moving faster than expected.
berkeleyearth.org
January 14, 2026 at 10:24 PM
Lest we forget the greatest global challenge we all are facing...
Life saving/extending drug approved for bowel cancer patients thanks to biosimilar re-appraisal after £££ branded drug rejected.
I lobbied NICE for over 2 years & they listened! Bevacizumab is the START. More biosimilars/generics should now follow
www.nice.org.uk/news/article...
I lobbied NICE for over 2 years & they listened! Bevacizumab is the START. More biosimilars/generics should now follow
www.nice.org.uk/news/article...
Thousands more people with advanced bowel cancer to benefit as NICE approves bevacizumab biosimilars
www.nice.org.uk
January 8, 2026 at 6:07 PM
Life saving/extending drug approved for bowel cancer patients thanks to biosimilar re-appraisal after £££ branded drug rejected.
I lobbied NICE for over 2 years & they listened! Bevacizumab is the START. More biosimilars/generics should now follow
www.nice.org.uk/news/article...
I lobbied NICE for over 2 years & they listened! Bevacizumab is the START. More biosimilars/generics should now follow
www.nice.org.uk/news/article...
NEW Podcast Out - My chat with legendary BBC foreign correspondent & film maker, Martin Sixsmith. Found lots in common - living behind Iron Curtain, US @commonwealthfund.org fellowship, working in government, storytelling & making sense of a divided world
harknessfellows.org.uk/podcasts/luk...
harknessfellows.org.uk/podcasts/luk...
Luke O’Shea & Martin Sixsmith - Harkness Fellows
Despite fellowships more than thirty years apart and on opposite sides of the USA, Luke and Martin find they have much in common. From school drills for security, through living in communist countries...
harknessfellows.org.uk
December 9, 2025 at 8:57 AM
NEW Podcast Out - My chat with legendary BBC foreign correspondent & film maker, Martin Sixsmith. Found lots in common - living behind Iron Curtain, US @commonwealthfund.org fellowship, working in government, storytelling & making sense of a divided world
harknessfellows.org.uk/podcasts/luk...
harknessfellows.org.uk/podcasts/luk...
Great meeting staff on the wards and in theatres today & talking sustainability. We’ve spoken to 450 staff across UCLH this month about improving hand hygiene and reducing glove use. Better for patients, better for the planet and saves money too.
November 28, 2025 at 1:27 PM
Great meeting staff on the wards and in theatres today & talking sustainability. We’ve spoken to 450 staff across UCLH this month about improving hand hygiene and reducing glove use. Better for patients, better for the planet and saves money too.
Visited Hospital de Sant Pau. Breathtaking art nouveau hospital in Barcelona. Incredible and window into 1920s medicine and earliest net zero hospital, powered on geothermal from 400 wells each 100 deep. Wow
November 15, 2025 at 9:21 PM
Visited Hospital de Sant Pau. Breathtaking art nouveau hospital in Barcelona. Incredible and window into 1920s medicine and earliest net zero hospital, powered on geothermal from 400 wells each 100 deep. Wow
On a 285 km/hr train to Barcelona for a health conference where am speaking about innovation and also climate action. Wonderful experience, comfy, fast WIFI, good catering. So much nicer than flying! Just over £46 each way. So much cheaper than UK trains too!
November 13, 2025 at 9:24 AM
On a 285 km/hr train to Barcelona for a health conference where am speaking about innovation and also climate action. Wonderful experience, comfy, fast WIFI, good catering. So much nicer than flying! Just over £46 each way. So much cheaper than UK trains too!
Great to speak at #KFAnnual Conf on climate & our work @uclh. Serious stuff but there is hope, as we have the solutions. Good climate strategy does not run against finance, tech or quality, but harnesses them. The NHS can lead the world in this & build green economic growth @thekingsfund.bsky.social
November 6, 2025 at 4:20 PM
Great to speak at #KFAnnual Conf on climate & our work @uclh. Serious stuff but there is hope, as we have the solutions. Good climate strategy does not run against finance, tech or quality, but harnesses them. The NHS can lead the world in this & build green economic growth @thekingsfund.bsky.social
CAR-T cell therapy is one of the biggest breakthrough cancer treatments in recent years. Proud that @uclh is trialing its use for multiple sclerosis for the first time. Extraordinary science and fascinating development for autoimmune conditions
gbr01.safelinks.protection.outlook.com?url=https%3A...
gbr01.safelinks.protection.outlook.com?url=https%3A...
Woman has new multiple sclerosis treatment that doctors say could be 'game-changer'
Doctors are looking to recruit more people for the trial, which they say could one day be given as a single one-off treatment.
gbr01.safelinks.protection.outlook.com
October 24, 2025 at 1:10 PM
CAR-T cell therapy is one of the biggest breakthrough cancer treatments in recent years. Proud that @uclh is trialing its use for multiple sclerosis for the first time. Extraordinary science and fascinating development for autoimmune conditions
gbr01.safelinks.protection.outlook.com?url=https%3A...
gbr01.safelinks.protection.outlook.com?url=https%3A...
Exhausted but elated after incredible week rethinking clinic letters for the modern era. Brought GPs, @uclh staff, patients together for a huge push. The time, safety challenges, cost & impact on GP & hospital staff is vast. Got down to 9 key solutions, 1 worked up prototype & we’re done ✔️
October 17, 2025 at 5:17 PM
Exhausted but elated after incredible week rethinking clinic letters for the modern era. Brought GPs, @uclh staff, patients together for a huge push. The time, safety challenges, cost & impact on GP & hospital staff is vast. Got down to 9 key solutions, 1 worked up prototype & we’re done ✔️
Excited to start our clinic letter sprint today with patients, GPs, @uclh clinicians, techies and administrators. Letters have a massive role, safety critical, hugely expensive and time consuming. Major challenges outlined today, so looking forward to what we can do about it
October 13, 2025 at 8:03 PM
Excited to start our clinic letter sprint today with patients, GPs, @uclh clinicians, techies and administrators. Letters have a massive role, safety critical, hugely expensive and time consuming. Major challenges outlined today, so looking forward to what we can do about it
The delicate parasol of the Pleated Inkcap. This fragile fungi lives for only 24 hours. Nature is amazing. Let's protect it
October 12, 2025 at 12:14 PM
The delicate parasol of the Pleated Inkcap. This fragile fungi lives for only 24 hours. Nature is amazing. Let's protect it
On wards today at uclh
- remarkable clinical skills & v complex patients. ⬆️ role for generalists
- Ward round strategy key, but not standardised
- many reasons for discharge delays
- disposable curtains are v hard to draw
- scrubs pockets are too small &📱falls out
- remarkable clinical skills & v complex patients. ⬆️ role for generalists
- Ward round strategy key, but not standardised
- many reasons for discharge delays
- disposable curtains are v hard to draw
- scrubs pockets are too small &📱falls out
October 1, 2025 at 6:05 PM
On wards today at uclh
- remarkable clinical skills & v complex patients. ⬆️ role for generalists
- Ward round strategy key, but not standardised
- many reasons for discharge delays
- disposable curtains are v hard to draw
- scrubs pockets are too small &📱falls out
- remarkable clinical skills & v complex patients. ⬆️ role for generalists
- Ward round strategy key, but not standardised
- many reasons for discharge delays
- disposable curtains are v hard to draw
- scrubs pockets are too small &📱falls out
Stunning news from UCLH on this incredible Huntington’s disease breakthrough. Nice to see some evidence based positive medical news!
www.uclh.nhs.uk/news/hunting...
www.uclh.nhs.uk/news/hunting...
Huntington’s Disease gene therapy shows 75 per cent slowing of disease
A new gene therapy to treat Huntington’s disease has shown positive data from the study of AMT-130 which is being run at UCLH and other sites.
www.uclh.nhs.uk
September 25, 2025 at 11:24 AM
Stunning news from UCLH on this incredible Huntington’s disease breakthrough. Nice to see some evidence based positive medical news!
www.uclh.nhs.uk/news/hunting...
www.uclh.nhs.uk/news/hunting...
Rain and shine in Paddington
September 3, 2025 at 6:51 PM
Rain and shine in Paddington
Watching a merganser fishing in France. Nature is incredible. Let's protect it.
August 23, 2025 at 7:46 PM
Watching a merganser fishing in France. Nature is incredible. Let's protect it.
Important to spread hope. People are now putting up a gigawatt’s worth of solar panels, the rough equivalent of the power generated by one coal-fired plant, every fifteen hours… www.newyorker.com/news/annals-...
4.6 Billion Years On, the Sun Is Having a Moment
In the past two years, without much notice, solar power has begun to truly transform the world’s energy system.
www.newyorker.com
August 5, 2025 at 7:43 PM
Important to spread hope. People are now putting up a gigawatt’s worth of solar panels, the rough equivalent of the power generated by one coal-fired plant, every fifteen hours… www.newyorker.com/news/annals-...
The rise of YouTube shorts in the last year is mind blowing. Up to 200 billion daily views or over 1 billion hrs a day. In a world of 8 bn people! Will any productivity gains from AI simply be offset by increasingly effective tech distractions? www.thewrap.com/youtube-shor...
YouTube Shorts Now Averages 200 Billion Daily Views
YouTube Shorts now averages 200 billion daily views, CEO Neal Mohan announced during his keynote at Cannes Lions 2025.
www.thewrap.com
June 23, 2025 at 3:02 PM
The rise of YouTube shorts in the last year is mind blowing. Up to 200 billion daily views or over 1 billion hrs a day. In a world of 8 bn people! Will any productivity gains from AI simply be offset by increasingly effective tech distractions? www.thewrap.com/youtube-shor...
Great #FestivalofExcellence hearing superb improvement work UCLH. I talked about quality, & why spending more ≠ better outcomes. Gave 3 case studies which show drive quality ⬆️ then cost ⬇️ (hip surgery, gloves off, clinic letters). Complexity the enemy of reliability & quality
June 3, 2025 at 4:52 PM
Great #FestivalofExcellence hearing superb improvement work UCLH. I talked about quality, & why spending more ≠ better outcomes. Gave 3 case studies which show drive quality ⬆️ then cost ⬇️ (hip surgery, gloves off, clinic letters). Complexity the enemy of reliability & quality
Person centred care at it's best! Uclh team working across services to enable one of our young, severely needle phobic patients to get the vaccinations needed to visit his family abroad for the first time. (Spoiler alert: solution was to vax when under general for his dental work) buff.ly/pFxkkcj
Autistic teen with needle phobia helped to go abroad by NHS
Terence Panzu-Lema is given the ability to travel abroad for the first time, by a unique collaboration by NHS teams.
buff.ly
May 17, 2025 at 8:26 AM
Person centred care at it's best! Uclh team working across services to enable one of our young, severely needle phobic patients to get the vaccinations needed to visit his family abroad for the first time. (Spoiler alert: solution was to vax when under general for his dental work) buff.ly/pFxkkcj
BIG STORY which brings hope! China's emissions are dropping for the first time! This really matters as China has more than a third of global emissions. Wow. www.carbonbrief.org/analysis-cle... Climate action on a massive scale
Analysis: Clean energy just put China’s CO2 emissions into reverse for first time - Carbon Brief
For the first time, the growth in China’s clean power generation has caused the nation’s carbon dioxide (CO2) emissions to fall despite rapid power demand growth.
www.carbonbrief.org
May 15, 2025 at 5:58 PM
BIG STORY which brings hope! China's emissions are dropping for the first time! This really matters as China has more than a third of global emissions. Wow. www.carbonbrief.org/analysis-cle... Climate action on a massive scale
It’s quite incredible what UCLH staff do for our patients. Take outpatients, where last year we did over 1.4m appointments up about 100k on the year before. Some weeks we saw 30,000 patients. The NHS is under huge pressure but the work of our staff is just remarkable
April 24, 2025 at 4:35 PM
It’s quite incredible what UCLH staff do for our patients. Take outpatients, where last year we did over 1.4m appointments up about 100k on the year before. Some weeks we saw 30,000 patients. The NHS is under huge pressure but the work of our staff is just remarkable
Great to have the Chinese Health Minister come to see first-hand what we are doing at UCLH on sustainability. The Chinese Government is responsible for the largest hospital sector in the world, so discussing net zero is important. Minister was full of praise for our staff’s work
March 20, 2025 at 5:38 PM
Great to have the Chinese Health Minister come to see first-hand what we are doing at UCLH on sustainability. The Chinese Government is responsible for the largest hospital sector in the world, so discussing net zero is important. Minister was full of praise for our staff’s work
Oxford sparkling tonight
March 6, 2025 at 10:08 PM
Oxford sparkling tonight
Sat in on a superb UCLH ENT clinic today trialing ambient AI to write notes/letters
- patients & clinicians happy
- shifts doc from writer to proof reader
- saves time but justifies £?
- incredibly complex case worked well
- no idea why send letters every time, even if AI helps
- patients & clinicians happy
- shifts doc from writer to proof reader
- saves time but justifies £?
- incredibly complex case worked well
- no idea why send letters every time, even if AI helps
March 5, 2025 at 7:11 PM
Sat in on a superb UCLH ENT clinic today trialing ambient AI to write notes/letters
- patients & clinicians happy
- shifts doc from writer to proof reader
- saves time but justifies £?
- incredibly complex case worked well
- no idea why send letters every time, even if AI helps
- patients & clinicians happy
- shifts doc from writer to proof reader
- saves time but justifies £?
- incredibly complex case worked well
- no idea why send letters every time, even if AI helps
Loved speaking on electronic health records, including on critical need to focus on adoption, that digitisation in itself does not guarantee transformation and the implications of hardwiring EHRs into so much of what we do. Great debate.
Brilliant discussion with colleagues from @ouhospitals.bsky.social @cuhnhs.bsky.social @microsoft.com and @lukeoshea.bsky.social and @nellthornton.bsky.social about the role of AI in delivering improved healthcare, including the trade-offs we need to discuss with the public #Shelford2025
February 25, 2025 at 4:13 PM
Loved speaking on electronic health records, including on critical need to focus on adoption, that digitisation in itself does not guarantee transformation and the implications of hardwiring EHRs into so much of what we do. Great debate.