Loren Williams
lorendw.bsky.social
Loren Williams
@lorendw.bsky.social
I work on the ribosome, the origins of life, evolution and biological chemistry.
The amazing world of protein function, from Kavita's paper.
March 14, 2025 at 4:12 AM
RNA World, help.
1) Chicken & Egg: Multiple types of complex polymers (RNA and protein) cannot arise simultaneously.
2) Extant reflects ancient: extant functions of RNA are direct reflections of prebiotic behaviors.
3) Parsimony. The RNA world is simple. A simple model is a good model.
Is that it?
March 14, 2025 at 3:58 AM
My second ever Bluesky post:

Another part of the work of my wonderful graduate student Kavita Matange (post doc at CSHL) has come out here (open access).

pubs.acs.org/doi/full/10....
Biological Polymers: Evolution, Function, and Significance
ConspectusA holistic description of biopolymers and their evolutionary origins will contribute to our understanding of biochemistry, biology, the origins of life, and signatures of life outside our pl...
pubs.acs.org
March 8, 2025 at 5:05 AM
I apologize that that paper is behind a paywall. You can access it free here:

williams.chemistry.gatech.edu/publications...
williams.chemistry.gatech.edu
March 8, 2025 at 5:03 AM
My first ever Bluesky post:
Some of the work of my wonderful graduate student Kavita Matange (now a post doc at CSHL) has just come out.
www.nature.com/articles/s41...
Evolution of complex chemical mixtures reveals combinatorial compression and population synchronicity - Nature Chemistry
Origins-of-life research has focused on specific chemical reactions that might lead to biological molecules. Now an experimental model of chemical evolution based on oscillating water activity has bee...
www.nature.com
March 8, 2025 at 4:58 AM