In a groundbreaking study poised to transform our understanding of genetic cancer risks, researchers have unveiled new insights into the differential impacts of BRCA1 gene founder variants on

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Background The global trend toward delayed childbearing has led to an increased use of fertility treatment, including in vitro fertilization (IVF) and hormonal medications. Concerns regarding the pote...

Breast cancer is the most frequent malignancy among young women, with unique challenges particularly for carriers of BRCA pathogenic or likely pathogenic varian...

Olaparib is approved for the treatment of germline BRCA mutant (gBRCAm) high-risk early breast cancer (eBC) following treatment with neoadjuvant or adjuvant chemotherapy. The potential long-term ou...

How I Found Strength While Facing Breast Cancer — Twice

Explore innovative menopause management strategies for BRCA carriers, including testosterone therapy, to alleviate symptoms and enhance quality of life.

Individuals with increased familial or genetic risk of pancreatic cancer (PC) may be recommended to undergo regular PC surveillance. Genetic counselors are often involved in discussions about PC surveillance for high‐risk individuals (HRIs); ...

Breast cancer remains the most frequently diagnosed malignancy among women worldwide, posing a significant threat to public health despite ongoing advances in detection and treatment. Approximately 5

BRCA gene mutations are linked to a higher chance of developing prostate cancer at a younger age and in a more aggressive form

Stress may increase cancer risk in people with inherited cancer genes

On Oct. 11, we celebrate International Day of the Girl, a global call to recognize girls’ rights and confront persistent inequality. When hope wavers and progress stalls, I look for words that steady...

Research shows germline genetic testing — testing for a cancer risk gene you may have inherited — can save lives. Not just a patient’s, but their family members, as well. Hereditary Cancer Awareness W...

This cohort study tests whether the oral bacterial and fungal microbiome is associated with the subsequent development of pancreatic cancer.

Introduction: Deficiency in BRCA genes leads to impediment in DNA repair and is associated with an increased lifetime risk of breast, ovarian, prostate, and pancreatic cancer and melanoma. Lynch synd...

Medullary breast cancer is a rare subtype of invasive breast cancer, representing from 0.2% to 6% of all breast carcinomas, with a higher proportion among women with triple-negative breast cancer and among those with a BRCA1 mutation. This review article aims to investigate the frequency of medullary breast cancer among all breast cancers and to assess its association with BRCA1 mutations. We surveyed studies involving patients diagnosed with breast cancer that report both the histology of the breast cancer as well as the presence of BRCA1 mutations. Among women with medullary breast cancer, the proportion of cases that carry a BRCA1 mutation ranges from 3% up to 35.3%, depending on the study. Among BRCA1-mutated breast cancers, the proportion that are medullary ranges from 8 to 20%. Given the notable association between medullary breast cancer and BRCA1 mutations, we propose to consider medullary breast cancer as a criterion for genetic testing in order to improve the identification of a larger number of carriers, thereby enhancing screening and prevention strategies.

This comparative effectiveness research study considers how to define clinical effectiveness from prospective cohort studies of women undergoing early salpingectomy with delayed oophortectomy vs salpi...

For years, I have been on the other side of the consultation table — guiding women through some of the most difficult decisions of their lives. As a breast oncoplastic surgeon, I have sat with mothers...

About three years ago, Stephanie Donati of DuBois was busy prepping her yard and outdoor furniture for the coming winter. But the aches and pains from...

This cohort study examines the prevalence of pathogenic or likely pathogenic variants in BRCA1 and BRCA2 in women with breast cancer in a racially and ethnically diverse population.

American voters might not have realized that a Republican victory in 2024 would mean sweeping cuts to cancer research, but that’s what they’re getting.