Nils Lindstrom
@lindstromlab.bsky.social
Stem cell biologist wanting build an artificial kidney and understand development. My lab is at https://lindstromlab.usc.edu/
Director of ASCEND
See our spatial transcriptomic, organoid, and stem cell program https://ascend.usc.edu
Director of ASCEND
See our spatial transcriptomic, organoid, and stem cell program https://ascend.usc.edu
Excited we can generate nephron cells for preclinical trials. We will continue to perfect the proximal tubule model and are going deep into understanding nephron injury programs and following up on druggable targets that could solve acute kidney injury and maladaptive repair.
A Nature Communications paper from Nils Lindström's lab at USC Stem Cell identifies key molecular switches that generate distinct cell types within the kidney’s filtering units, or nephrons. The lab is getting closer to making therapeutic kidney cells on demand! stemcell.keck.usc.edu/scientists-u...
September 3, 2025 at 8:18 PM
Excited we can generate nephron cells for preclinical trials. We will continue to perfect the proximal tubule model and are going deep into understanding nephron injury programs and following up on druggable targets that could solve acute kidney injury and maladaptive repair.
Mostly, just advertising Jack Schnell's* impeccable taste in figure color choices. *soon to be first set of Ph.D. graduates from lab @lindstromlab.bsky.social. Here he describes the development of nephron cells in stem cell derived kidneys.
December 16, 2024 at 5:03 AM
Mostly, just advertising Jack Schnell's* impeccable taste in figure color choices. *soon to be first set of Ph.D. graduates from lab @lindstromlab.bsky.social. Here he describes the development of nephron cells in stem cell derived kidneys.
Recent preprint with @leonardomorsut.bsky.social. We perform detailed spatial transcriptional analyses of human kidney development to resolve how nephrons pattern, and build synthetic cell organizers to copy axial patterning using stem cells derived nephrons. www.biorxiv.org/content/10.1...
Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers
Current human pluripotent stem cell-derived kidney organoids contain nephron-like structures that lack organotypic patterning. It is thought that during human development, nephrons form their proximal...
www.biorxiv.org
December 15, 2024 at 12:00 AM
Recent preprint with @leonardomorsut.bsky.social. We perform detailed spatial transcriptional analyses of human kidney development to resolve how nephrons pattern, and build synthetic cell organizers to copy axial patterning using stem cells derived nephrons. www.biorxiv.org/content/10.1...
Happy holidays! A very cool looking kidney organoid, courtesy of senior Ph.D. student MaryAnne Achieng in the @lindstromlab.bsky.social.
December 14, 2024 at 9:43 PM
Happy holidays! A very cool looking kidney organoid, courtesy of senior Ph.D. student MaryAnne Achieng in the @lindstromlab.bsky.social.
Reposted by Nils Lindstrom
So excited to share our new @natureportfolio.bsky.social review on modeling human brain development using organoids! 🧠 Loved collaborating with the brilliant @lancasterlab.bsky.social , led by the incredible @marcellabirtele.bsky.social Check it out! 🔬 #Neuroscience #BrainOrganoids rdcu.be/d3llp
Modelling human brain development and disease with organoids
Nature Reviews Molecular Cell Biology - This Roadmap article discusses recent advances in the production and use of brain organoids to understand brain development and associated disorders. The...
rdcu.be
December 12, 2024 at 7:36 PM
So excited to share our new @natureportfolio.bsky.social review on modeling human brain development using organoids! 🧠 Loved collaborating with the brilliant @lancasterlab.bsky.social , led by the incredible @marcellabirtele.bsky.social Check it out! 🔬 #Neuroscience #BrainOrganoids rdcu.be/d3llp
Reposted by Nils Lindstrom
Want to highlight how a really fun collaborative project, Nils is as close as it gets to the prototypical omniscient kidney developmental biologist, it was so fun to learn from him about this fascinating developmental system. @lindstromlab.bsky.social
December 13, 2024 at 12:50 AM
Want to highlight how a really fun collaborative project, Nils is as close as it gets to the prototypical omniscient kidney developmental biologist, it was so fun to learn from him about this fascinating developmental system. @lindstromlab.bsky.social
Reposted by Nils Lindstrom
We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells
Nature Protocols - Generation and long-term culture of a human pluripotent stem cell-derived human cerebellar organoid model, which successfully replicates the cellular diversity of the fetal...
rdcu.be
December 3, 2024 at 1:18 AM
We're excited to share our comprehensive protocol for generating human cerebellar #organoids, addressing the many requests we've received from the scientific community! Congratulations to Alex Atamian, @marcellabirtele.bsky.social, and Negar Hosseini! rdcu.be/d13Zu @natureportfolio.bsky.social