@leizhong.bsky.social
PhD in @Suessmuth_lab, TU Berlin. Research on structural elucidation and biosynthesis of bioactive secondary metabolites (NRPs/PKs) from 🦠.
Reposted
Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...
#naturalproducts #antibiotic #amr #drugdiscovery #drug
#naturalproducts #antibiotic #amr #drugdiscovery #drug
Natural product-derived compounds in clinical trials and drug approvals
Covering: January 2014–June 2025. Previous review: Natural Product Reports, 2014, 31, 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery ...
pubs.rsc.org
September 10, 2025 at 3:01 PM
Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...
#naturalproducts #antibiotic #amr #drugdiscovery #drug
#naturalproducts #antibiotic #amr #drugdiscovery #drug
#Suessmuth_Lab #Synpepbio
We are delighted and grateful to see our recent work highlighted on the #American_Peptide_Society website.
americanpeptidesociety.org/aps-news/pot...
We are delighted and grateful to see our recent work highlighted on the #American_Peptide_Society website.
americanpeptidesociety.org/aps-news/pot...
Potent Antifungal Lipopeptide
Potent Antifungal Lipopeptide
americanpeptidesociety.org
July 4, 2025 at 10:44 AM
#Suessmuth_Lab #Synpepbio
We are delighted and grateful to see our recent work highlighted on the #American_Peptide_Society website.
americanpeptidesociety.org/aps-news/pot...
We are delighted and grateful to see our recent work highlighted on the #American_Peptide_Society website.
americanpeptidesociety.org/aps-news/pot...
#SüssmuthLab We have investigated the structure, bioactivity, and biosynthesis of AFC-BC11, an antifungal lipopeptide whose structure has remained unresolved since its discovery in 1998. Just published in JACS (@jacs.acspublications.org):
#NaturalProduct #Antifungal 🇩🇪🇫🇷
#NaturalProduct #Antifungal 🇩🇪🇫🇷
The Intricate Nonribosomal Assembly of a Potent Antifungal Lipopeptide from the Burkholderia cepacia Complex
The Burkholderia cepacia complex (BCC) is a group of Gram-negative bacteria known for their pathogenicity to patients suffering from cystic fibrosis (CF). The BCC-belonging strain B. pyrrocinia BC11 (...
pubs.acs.org
June 3, 2025 at 9:06 AM
#SüssmuthLab We have investigated the structure, bioactivity, and biosynthesis of AFC-BC11, an antifungal lipopeptide whose structure has remained unresolved since its discovery in 1998. Just published in JACS (@jacs.acspublications.org):
#NaturalProduct #Antifungal 🇩🇪🇫🇷
#NaturalProduct #Antifungal 🇩🇪🇫🇷
Reposted
Interested in natural product producing microorganisms? 🦠 See you in Berlin... 😀
May 22, 2025 at 1:02 PM
Interested in natural product producing microorganisms? 🦠 See you in Berlin... 😀
Our new paper is out! In collaboration with Flavia Marinelli’s and Oleksandr Yushchuk’s groups, we report the discovery of Kineomicin, a novel glycopeptide antibiotic featuring a unique scaffold: Hpg at AA1 and isoleucine at AA3. #antibiotics #naturalproducts
Just out: A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650
A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650
Communications Chemistry, Published online: 03 May 2025; doi:10.1038/s42004-025-01534-xThe rise of bacterial resistance necessitates the discovery of novel antibiotics, particularly the last-resort glycopeptide antibiotics (GPAs). Here, the authors identify a unique biosynthetic gene cluster in Actinokineospora auranticolor, leading to the discovery of kineomicins, a new class of GPAs with high production potential.
bit.ly
May 3, 2025 at 9:11 PM
Our new paper is out! In collaboration with Flavia Marinelli’s and Oleksandr Yushchuk’s groups, we report the discovery of Kineomicin, a novel glycopeptide antibiotic featuring a unique scaffold: Hpg at AA1 and isoleucine at AA3. #antibiotics #naturalproducts
New Review Article
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
onlinelibrary.wiley.com/share/M8VFCW...
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
onlinelibrary.wiley.com/share/M8VFCW...
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
You have to enable JavaScript in your browser's settings in order to use the eReader.
onlinelibrary.wiley.com
February 11, 2025 at 10:26 PM
New Review Article
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
onlinelibrary.wiley.com/share/M8VFCW...
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
onlinelibrary.wiley.com/share/M8VFCW...
Reposted
New online! Microbial secondary metabolites: advancements to accelerate discovery towards application
Microbial secondary metabolites: advancements to accelerate discovery towards application
Nature Reviews Microbiology, Published online: 17 January 2025; doi:10.1038/s41579-024-01141-yIn this Review, Dinglasan and colleagues explore innovations that facilitate rapid microbial secondary metabolite discovery, focusing on recent techniques for…
go.nature.com
January 17, 2025 at 12:49 PM
New online! Microbial secondary metabolites: advancements to accelerate discovery towards application
Reposted
~5y ago, Barbara, Serina, @marnixmedema.bsky.social & I teamed up to make a better NRPS A-domain specificity predictor. The Challis group & others joined along the way to add some very cool insights.
Very proud of this work. Check it out now on biorxiv!
doi.org/10.1101/2025...
Very proud of this work. Check it out now on biorxiv!
doi.org/10.1101/2025...
PARAS: high-accuracy machine-learning of substrate specificities in nonribosomal peptide synthetases
Nonribosomal peptides are chemically and functionally diverse natural products with important applications in medicine and agriculture. Bacterial and fungal genomes contain thousands of nonribosomal p...
doi.org
January 12, 2025 at 6:31 PM
~5y ago, Barbara, Serina, @marnixmedema.bsky.social & I teamed up to make a better NRPS A-domain specificity predictor. The Challis group & others joined along the way to add some very cool insights.
Very proud of this work. Check it out now on biorxiv!
doi.org/10.1101/2025...
Very proud of this work. Check it out now on biorxiv!
doi.org/10.1101/2025...
Reposted
#Symposium #Omics #Mining #Wageningen @WUR
Join @marnixmedema and myself to 🎉 celebrate 🎉 10 years of genome mining and 5 years of metabolome mining in Wageningen! #Computational #Genomics #Metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
Join @marnixmedema and myself to 🎉 celebrate 🎉 10 years of genome mining and 5 years of metabolome mining in Wageningen! #Computational #Genomics #Metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
Justin J.J. van der Hooft on LinkedIn: #wageningen #campus #computational #genomics #metabolomics…
🚨 Symposium Announcement & Invitation 🚨
On March 26th, 2025, Marnix Medema and myself will organise a symposium in the Omnia building of the #Wageningen…
www.linkedin.com
November 22, 2024 at 7:00 PM
#Symposium #Omics #Mining #Wageningen @WUR
Join @marnixmedema and myself to 🎉 celebrate 🎉 10 years of genome mining and 5 years of metabolome mining in Wageningen! #Computational #Genomics #Metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...
Join @marnixmedema and myself to 🎉 celebrate 🎉 10 years of genome mining and 5 years of metabolome mining in Wageningen! #Computational #Genomics #Metabolomics #CompMetabolomics
www.linkedin.com/posts/jjjvan...