Laoui Team @ VIB-VUB
@laouimmunology.bsky.social
Dendritic cell lovers, aiming to beat cancer
Pinned
Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity
Nature Communications - Local delivery of mRNA-based immunotherapy represents an option for cancer therapy. Here the authors report that intratumoral delivery of lipid nanoparticle-formulated mRNA...
rdcu.be
Excited to share our latest work in @NatureComms
! 🎉 LNP-formulated mRNA encoding IL-21, IL-7, & 4-1BB drives systemic anti-tumor immunity—spotlight on cDC2s! 👀 Led by Ahmed Hamouda, in collaboration with @eTheRNA_engine
& @bruno_de_geest. Read here: rdcu.be/d2zQ7
! 🎉 LNP-formulated mRNA encoding IL-21, IL-7, & 4-1BB drives systemic anti-tumor immunity—spotlight on cDC2s! 👀 Led by Ahmed Hamouda, in collaboration with @eTheRNA_engine
& @bruno_de_geest. Read here: rdcu.be/d2zQ7
🎯 New speaker alert: Jennifer Wargo (MD Anderson Cancer Center, US) will share cutting-edge advances in precision, genetically targeted cancer therapies at the THPT Conference.
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
October 22, 2025 at 2:55 PM
🎯 New speaker alert: Jennifer Wargo (MD Anderson Cancer Center, US) will share cutting-edge advances in precision, genetically targeted cancer therapies at the THPT Conference.
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 🗓️ 10–12 Dec | #THPT25
🔗 Early bird registration deadline: 29 October vibbio.tech/THPT25
The Tumor Heterogeneity, Plasticity & Therapy Conference welcomes Céline Vallot (@institutcurie.bsky.social) to share her research on epigenomic evolution of breast cancers at single-cell resolution.
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
October 11, 2025 at 9:09 AM
The Tumor Heterogeneity, Plasticity & Therapy Conference welcomes Céline Vallot (@institutcurie.bsky.social) to share her research on epigenomic evolution of breast cancers at single-cell resolution.
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
📍 Leuven | 📅 10–12 Dec | #THPT25
⏳ Early bird registration deadline: 29 October vibbio.tech/THPT25
🎉 Not 1, but 2 prizes! Huge congrats to our team members for their outstanding achievements at the 7th Research Day on Tumor Immunology and Immunotherapy!
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
October 11, 2025 at 9:05 AM
🎉 Not 1, but 2 prizes! Huge congrats to our team members for their outstanding achievements at the 7th Research Day on Tumor Immunology and Immunotherapy!
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
🏆 Alicia Gordun Pero–Poster Prize
🎤 Pauline Bardet–Selected Talk Prize
We’re proud to see their hard work and research being recognized 👏
At the Tumor Heterogeneity, Plasticity and Therapy Conference (#THPT25) in Leuven from 10–12 December, Eduard Batlle from IRB Barcelona will show how the tumor microenvironment can facilitate immune evasion and metastasis.
Abstract deadline: 8th of October
vibbio.tech/THPT25
Abstract deadline: 8th of October
vibbio.tech/THPT25
October 7, 2025 at 12:33 PM
At the Tumor Heterogeneity, Plasticity and Therapy Conference (#THPT25) in Leuven from 10–12 December, Eduard Batlle from IRB Barcelona will show how the tumor microenvironment can facilitate immune evasion and metastasis.
Abstract deadline: 8th of October
vibbio.tech/THPT25
Abstract deadline: 8th of October
vibbio.tech/THPT25
The Laoui Lab will be well represented at the Tumor Heterogeneity, Plasticity and Therapy (3rd edition) conference #THPT25! Join us to hear more about therapy resistence in #cancer from Anna Obenauf
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
October 7, 2025 at 12:27 PM
The Laoui Lab will be well represented at the Tumor Heterogeneity, Plasticity and Therapy (3rd edition) conference #THPT25! Join us to hear more about therapy resistence in #cancer from Anna Obenauf
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
@obenaufa.bsky.social
Submit your abstract by the 8th of October on vibbio.tech/THPT25
🚨 New publication!
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio-reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolera...
advanced.onlinelibrary.wiley.com
September 23, 2025 at 6:47 PM
🚨 New publication!
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
In a collaborative effort led by Etherna, we reveal how two optimized LNPs trigger distinct IgG2a vs IgG1 phenotypes.
This opens the door to tuning LNP design for tailored immune responses in mRNA vaccines & beyond.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Watching students grow into independent scientists is the best part of this job. Huge congrats to my first PhD student @matekiss.bsky.social stating his onw lab!
Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), please reach out if you know someone interested!
August 3, 2025 at 6:51 AM
Watching students grow into independent scientists is the best part of this job. Huge congrats to my first PhD student @matekiss.bsky.social stating his onw lab!
Reposted by Laoui Team @ VIB-VUB
Our new paper is out:
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment - Genome Medicine
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones ...
genomemedicine.biomedcentral.com
July 30, 2025 at 8:17 AM
Our new paper is out:
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive regulatory elements and priming pro-tumor gene programs.
Reposted by Laoui Team @ VIB-VUB
I am grateful to co-lead authors Laszlo Halasz and Eva Hadadi, and everyone involved from the labs of Jo Van Ginderachter, Laszlo Nagy, and Damya Laoui (@laouimmunology.bsky.social).
July 30, 2025 at 8:17 AM
I am grateful to co-lead authors Laszlo Halasz and Eva Hadadi, and everyone involved from the labs of Jo Van Ginderachter, Laszlo Nagy, and Damya Laoui (@laouimmunology.bsky.social).
Day 3 at #INCI25
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
May 9, 2025 at 10:27 AM
Day 3 at #INCI25
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
@movahedilab.bsky.social presented some fantastic images of brain immune niches as well as their recently published work in @cp-immunity.bsky.social on microglia replacement therapy. After the break, Christoph Scheiermann reminded us how much our day-night cycle impact immunity
Last presenter of the day at #INCI25, Michele De Palma presented some impressive results exploiting cytokine-armed dendritic cell progenitors as cancer therapy in anti-PD1 refractory lung cancer.
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
May 8, 2025 at 5:01 PM
Last presenter of the day at #INCI25, Michele De Palma presented some impressive results exploiting cytokine-armed dendritic cell progenitors as cancer therapy in anti-PD1 refractory lung cancer.
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
Now up to enjoy our boat tour in the beautiful Bruges and socialize with our fellow-scientists!
We finish the Cell Therapy session at #INCI25 with two top speakers. First, Tobias Weiss provided an overview of the next-generation therapies for glioblastoma from antibody-cytokine fusion proteins to cytokine-expressing CAR-T cells and exploiting macrophages as drug delivery platform.
May 8, 2025 at 3:23 PM
We finish the Cell Therapy session at #INCI25 with two top speakers. First, Tobias Weiss provided an overview of the next-generation therapies for glioblastoma from antibody-cytokine fusion proteins to cytokine-expressing CAR-T cells and exploiting macrophages as drug delivery platform.
After presenting my poster at #INCI25 about the potential of CD40 agonist to enhance anti tumor immunity of tumor-derived cDCs, the session started with an excellent talk by Gabriele Bergers about the key role of the diva’s of endothelial cells, the high endothelial venules in anti-tumor immunity!
May 8, 2025 at 1:16 PM
After presenting my poster at #INCI25 about the potential of CD40 agonist to enhance anti tumor immunity of tumor-derived cDCs, the session started with an excellent talk by Gabriele Bergers about the key role of the diva’s of endothelial cells, the high endothelial venules in anti-tumor immunity!
Day 2 at #INCI25 started with a great neuro-immuno crosstalk session.
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
May 8, 2025 at 8:52 AM
Day 2 at #INCI25 started with a great neuro-immuno crosstalk session.
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
As selected abstract, VIB Alumni Ilaria Decimo showed us her exciting work uncovering that TAMs can promote neuronal growth and can be exploited to restore functional motor recovery in a mouse model of spinal cord injury!
Another great talk by Pablo Vargas @leukomotion.bsky.social at #INCI25!
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
May 7, 2025 at 2:07 PM
Another great talk by Pablo Vargas @leukomotion.bsky.social at #INCI25!
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
His strategy, question the lack of hereditary immunodeficiencies linked to leukocyte motility! The DNA damage protein ATM came out as unexpected candidate with ATM inhibition reducing leukocyte motility in 3D matrices
After some lunch and the first poster session, we are ready for the afternoon session with my fellow conference reporters to report back on the most interesting talks at #INCI25.
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
May 7, 2025 at 12:38 PM
After some lunch and the first poster session, we are ready for the afternoon session with my fellow conference reporters to report back on the most interesting talks at #INCI25.
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
So follow @tommasoscolaro.bsky.social and @vibtrainconf.bsky.social to learn about the newest hot topics!
We finished our first extremely interesting morning session at #INCI25!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
May 7, 2025 at 9:42 AM
We finished our first extremely interesting morning session at #INCI25!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
As selected abstract, @gretamattavelli.bsky.social from the @riedel-lab.bsky.social was the last to present her PhD work on the role of lymph nodes in metastasis formation before the break!
Ready for a full day of interesting talks at the Immune Niches in Cancer and Inflammation #INCI25 conference in the beautiful Bruges 🙂 @viblifesciences.bsky.social
May 7, 2025 at 7:03 AM
Ready for a full day of interesting talks at the Immune Niches in Cancer and Inflammation #INCI25 conference in the beautiful Bruges 🙂 @viblifesciences.bsky.social
Very proud of Pauline Bardet, PhD student in our lab for not only presenting her work on SEPARATE-Seq as a new method to characterise our novel orthotopic lung cancer model at the VIB seminar, but also winning the prize for best presentation👏 @viblifesciences.bsky.social #scRNAseq #cancerresearch
April 25, 2025 at 3:55 PM
Very proud of Pauline Bardet, PhD student in our lab for not only presenting her work on SEPARATE-Seq as a new method to characterise our novel orthotopic lung cancer model at the VIB seminar, but also winning the prize for best presentation👏 @viblifesciences.bsky.social #scRNAseq #cancerresearch
The Immune Niches in Cancer and Inflammation conference #INCI25 is almost here
⏰Registration closes April 23rd
Don't miss this chance to hear more from Tobias Weiss who will share his insights into novel immunotherapeutic strategies for glioblastoma treatment!
🔗 vibbio.tech/INCI25
⏰Registration closes April 23rd
Don't miss this chance to hear more from Tobias Weiss who will share his insights into novel immunotherapeutic strategies for glioblastoma treatment!
🔗 vibbio.tech/INCI25
April 22, 2025 at 12:54 PM
The Immune Niches in Cancer and Inflammation conference #INCI25 is almost here
⏰Registration closes April 23rd
Don't miss this chance to hear more from Tobias Weiss who will share his insights into novel immunotherapeutic strategies for glioblastoma treatment!
🔗 vibbio.tech/INCI25
⏰Registration closes April 23rd
Don't miss this chance to hear more from Tobias Weiss who will share his insights into novel immunotherapeutic strategies for glioblastoma treatment!
🔗 vibbio.tech/INCI25
The final registration deadline for #INCI25 is approaching!
Register before the 23rd of April to join us in Bruges and learn more about leukocyte dynamics in immune pathologies from Pablo Vargas from the INEM in Paris.
Register now at vibbio.tech/INCI25
@leukomotion.bsky.social
Register before the 23rd of April to join us in Bruges and learn more about leukocyte dynamics in immune pathologies from Pablo Vargas from the INEM in Paris.
Register now at vibbio.tech/INCI25
@leukomotion.bsky.social
April 8, 2025 at 4:28 PM
The final registration deadline for #INCI25 is approaching!
Register before the 23rd of April to join us in Bruges and learn more about leukocyte dynamics in immune pathologies from Pablo Vargas from the INEM in Paris.
Register now at vibbio.tech/INCI25
@leukomotion.bsky.social
Register before the 23rd of April to join us in Bruges and learn more about leukocyte dynamics in immune pathologies from Pablo Vargas from the INEM in Paris.
Register now at vibbio.tech/INCI25
@leukomotion.bsky.social
Interested in hearing more about how our 🕐internal clock🕐 can influence anti-tumor immunity? Christoph Scheiermann will explain all about it at the Immune Niches in Cancer and Inflammation conference #INCI25 !
Don’t miss the early bird registration!
🚨Deadline: 26th of March
vibbio.tech/INCI25
Don’t miss the early bird registration!
🚨Deadline: 26th of March
vibbio.tech/INCI25
March 21, 2025 at 3:44 PM
Interested in hearing more about how our 🕐internal clock🕐 can influence anti-tumor immunity? Christoph Scheiermann will explain all about it at the Immune Niches in Cancer and Inflammation conference #INCI25 !
Don’t miss the early bird registration!
🚨Deadline: 26th of March
vibbio.tech/INCI25
Don’t miss the early bird registration!
🚨Deadline: 26th of March
vibbio.tech/INCI25
🚨Early Bird registration deadline for #INCI25 is approaching
Register before the 26th of March and join us in Bruges to hear more from Miriam Merad on the regulation of #TLS formation and maintenance in #cancer and discuss the role of #DCs in TLS 😃
@miriammerad.bsky.social
vibbio.tech/INCI25
Register before the 26th of March and join us in Bruges to hear more from Miriam Merad on the regulation of #TLS formation and maintenance in #cancer and discuss the role of #DCs in TLS 😃
@miriammerad.bsky.social
vibbio.tech/INCI25
March 13, 2025 at 9:06 AM
🚨Early Bird registration deadline for #INCI25 is approaching
Register before the 26th of March and join us in Bruges to hear more from Miriam Merad on the regulation of #TLS formation and maintenance in #cancer and discuss the role of #DCs in TLS 😃
@miriammerad.bsky.social
vibbio.tech/INCI25
Register before the 26th of March and join us in Bruges to hear more from Miriam Merad on the regulation of #TLS formation and maintenance in #cancer and discuss the role of #DCs in TLS 😃
@miriammerad.bsky.social
vibbio.tech/INCI25
Reposted by Laoui Team @ VIB-VUB
📢 Check out the first 🎙️ interview for our #WomenInScience campaign! 🎉
Damya Laoui shared her insights on the challenges women face in science, career paths, and breaking barriers. 💡🔬 The interview was led by Ewa Oleszycka, diving deep into these important topics! 👩🏼🔬
Damya Laoui shared her insights on the challenges women face in science, career paths, and breaking barriers. 💡🔬 The interview was led by Ewa Oleszycka, diving deep into these important topics! 👩🏼🔬
Login • Instagram
Welcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world.
www.instagram.com
March 7, 2025 at 12:47 PM
📢 Check out the first 🎙️ interview for our #WomenInScience campaign! 🎉
Damya Laoui shared her insights on the challenges women face in science, career paths, and breaking barriers. 💡🔬 The interview was led by Ewa Oleszycka, diving deep into these important topics! 👩🏼🔬
Damya Laoui shared her insights on the challenges women face in science, career paths, and breaking barriers. 💡🔬 The interview was led by Ewa Oleszycka, diving deep into these important topics! 👩🏼🔬
At the #INCI25, a full session is dedicated to #celltherapy. As dendritic cell aficionados, we are excited to hear more about engineered dendritic cells from expert in the field Michele De Palma from EPFL!
Join us and submit your abstract!
Abstract deadline: 28th of February
vibbio.tech/INCI25
Join us and submit your abstract!
Abstract deadline: 28th of February
vibbio.tech/INCI25
February 25, 2025 at 5:53 PM
At the #INCI25, a full session is dedicated to #celltherapy. As dendritic cell aficionados, we are excited to hear more about engineered dendritic cells from expert in the field Michele De Palma from EPFL!
Join us and submit your abstract!
Abstract deadline: 28th of February
vibbio.tech/INCI25
Join us and submit your abstract!
Abstract deadline: 28th of February
vibbio.tech/INCI25