Dr. Izzy Taylor
@labratiz.bsky.social
Assistant Professor at William & Mary studying quorum sensing in P. aeruginosa. Former Bassler Lab postdoc, Gestwicki Lab grad student. Bard Team Chem for life.
https://sites.google.com/view/taylorlabwm/home
https://sites.google.com/view/taylorlabwm/home
Another new preprint from our lab! This one details our efforts to produce new PqsE inhibitors and methods for assessing their potential to induce a conformational shift and weaken the interaction with RhlR. Haven't gotten there yet, but our methods are getting more sophisticated 😉
New inhibitors of the Pseudomonas aeruginosa enzyme, PqsE, and methods assessing their potential to induce a conformational change via active site binding https://www.biorxiv.org/content/10.1101/2025.10.07.680923v1
October 8, 2025 at 4:24 PM
Another new preprint from our lab! This one details our efforts to produce new PqsE inhibitors and methods for assessing their potential to induce a conformational shift and weaken the interaction with RhlR. Haven't gotten there yet, but our methods are getting more sophisticated 😉
We had a wonderful time at #ACSFall2025! Bilalay, Ada, and Maggie all presented posters and everyone learned new things/met new people. Can’t wait for the next one! @acs.org
August 22, 2025 at 7:21 PM
We had a wonderful time at #ACSFall2025! Bilalay, Ada, and Maggie all presented posters and everyone learned new things/met new people. Can’t wait for the next one! @acs.org
New preprint from our lab! Here we identified FDA-approved molecules that inhibit the enzyme activity of our favorite quorum sensing protein, PqsE. Work was led by 3 undergraduate and 1 MS student and in part comes from a collaboration with our Sep Lab neighbors! 🦠🧪
Screening of FDA-approved small molecules to discover inhibitors of the Pseudomonas aeruginosa quorum-sensing enzyme, PqsE https://www.biorxiv.org/content/10.1101/2025.07.25.666791v1
July 27, 2025 at 10:26 PM
New preprint from our lab! Here we identified FDA-approved molecules that inhibit the enzyme activity of our favorite quorum sensing protein, PqsE. Work was led by 3 undergraduate and 1 MS student and in part comes from a collaboration with our Sep Lab neighbors! 🦠🧪
Reposted by Dr. Izzy Taylor
@lizneeley.bsky.social is publishing a weekly newsletter to track the ongoing attacks in science and higher ed. If you want to keep abreast without drowning in the news, I recommend it: buttondown.com/liminalcreat...
February 1, 2025 at 5:34 PM
@lizneeley.bsky.social is publishing a weekly newsletter to track the ongoing attacks in science and higher ed. If you want to keep abreast without drowning in the news, I recommend it: buttondown.com/liminalcreat...
Reposted by Dr. Izzy Taylor
Small-molecule protein chaperones may have more wide-ranging activity than we thought, and that's good news:
Versatile Chaperones
www.science.org
January 15, 2025 at 8:40 PM
Small-molecule protein chaperones may have more wide-ranging activity than we thought, and that's good news:
Congrats to Bonnie!
Inbox: Biden announces winners of the National Medal of Science and the National Medal of Technology and Innovation, the nation’s highest honors for science and technology.
Among the notable names
- Jennifer Doudna, biochemist who’s done pioneering work with CRISPR
- Moderna
- Pfizer
Among the notable names
- Jennifer Doudna, biochemist who’s done pioneering work with CRISPR
- Moderna
- Pfizer
January 6, 2025 at 1:40 AM
Congrats to Bonnie!
Ok so Twitter doesn't really help with these things anymore. Anyone have grant rejection stories to share that'll make me feel better? I got this one on my third and final attempt for a particular grant. And it came in at 10 pm. On New Year's Eve. 🙃 #newPI #grantrejection
January 2, 2025 at 6:30 PM
Ok so Twitter doesn't really help with these things anymore. Anyone have grant rejection stories to share that'll make me feel better? I got this one on my third and final attempt for a particular grant. And it came in at 10 pm. On New Year's Eve. 🙃 #newPI #grantrejection
And with that, we have a new Survivor winner! And a totally deserving winner at that. #Survivor47
December 19, 2024 at 2:38 AM
And with that, we have a new Survivor winner! And a totally deserving winner at that. #Survivor47
Not loving that my first post on this app has a typo in it. Did we ever get that “edit post” button? 🤦🏻♀️
December 7, 2024 at 5:11 PM
Not loving that my first post on this app has a typo in it. Did we ever get that “edit post” button? 🤦🏻♀️
Very excited to share our lab's first preprint! This work was lead by 2 undergrad and one masters student: Bilalay Tchadi, Jesse Derringer, and Anna Detweiler. Here we describe the ability of our favorite enzyme, PqsE, to fine-tune RhlR's transcription factor activity in a promoter-specific manner:
PqsE acts as an adaptor protein for the quorum-sensing transcription factor RhlR in Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2024.12.03.626663v1
PqsE acts as an adaptor protein for the quorum-sensing transcription factor RhlR in Pseudomonas aeruginosa https://www.biorxiv.org/content/10.1101/2024.12.03.626663v1
Pseudomonas aeruginosa is a human pathogen that poses a significant health threat. Pathogenic behavi
www.biorxiv.org
December 4, 2024 at 3:16 PM
Very excited to share our lab's first preprint! This work was lead by 2 undergrad and one masters student: Bilalay Tchadi, Jesse Derringer, and Anna Detweiler. Here we describe the ability of our favorite enzyme, PqsE, to fine-tune RhlR's transcription factor activity in a promoter-specific manner: