Wright Laboratory
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Wright Laboratory
@labofwright.bsky.social
Bioinformatics Lab @DBMI Pitt
Home of DECIPHER, SynExtend & SubTap
#antibiotics #bioinformatics #evolution #evolution #R #Rstats
See publications here: https://scholar.google.com/citations?user=2R_ro8gAAAAJ&hl=en&oi=sra

Our EvoWeaver work is now included on the Computational and Theoretical Biology focus page of Nature Communications! The page highlights recent work that reports methodological advances in computational biology. www.nature.com/collections/...
Computational and Theoretical Biology
As we navigate the era of big data in biological research, advanced computational techniques, such as mathematical models and machine learning algorithms, are ...
www.nature.com
May 14, 2025 at 12:35 PM
Proud to announce a new publication from the lab: EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals
www.nature.com/articles/s41...
EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications
Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information....
www.nature.com
April 28, 2025 at 1:47 PM
🧪🧬🖥️ new paper: Tandem Repeats Provide Evidence for Convergent Evolution to Similar Protein Structures (doi.org/10.1093/gbe/...). You can also see the video explainer here: wrightlabscience.com/publications
Tandem Repeats Provide Evidence for Convergent Evolution to Similar Protein Structures
Abstract. Homology is a key concept underpinning the comparison of sequences across organisms. Sequence-level homology is based on a statistical framework
doi.org
February 24, 2025 at 2:02 PM
Nishant just came back from the EMSL at PNNL! wrightlabscience.com/news#oct2024
News
wrightlabscience.com
October 1, 2024 at 3:04 PM
One of our recently published articles has gotten traction in the popular press: www.thehindu.com/sci-tech/sci...
Vancomycin may not be able to treat MRSA infections for long
Researchers have found Staphylococcus aureus can adapt to vancomycin while overcoming its fitness cost, threatening the long-term use of vancomycin in the clinic.
www.thehindu.com
September 23, 2024 at 2:02 PM
New Paper Alert! VRSA can overcome the cost of antibiotic resistance and may threaten vancomycin's clinical durability, from our Master's student (and his second paper published this month!). www.wrightlabscience.com/publications
Publications
scientific publications, bioinformatics, genomes, research, antibiotics, antibiotic resistance, genomics, evolution
www.wrightlabscience.com
August 29, 2024 at 1:56 PM
One of the M.S. students got 2 papers accepted within days of each other! Here is one of them about #MachineLearning, #ElectronicHealthRecord Data, and #AntibioticResistance. #Bioinformatics has such a great place in our evolving healthcare landscape. 🧪 🧬🖥️
August 7, 2024 at 2:57 PM
We are at #ISMB2024! Come say hi! (I'm probably the tallest person at the conference)
July 15, 2024 at 6:40 PM
Updates to DECIPHER! It's now DECIPHERv3, with some cool updates! See wrightlabscience.com/news #bioinformatics #bioconductor #Genomics #biotechnology #R
May 1, 2024 at 6:41 PM
One of the lab members was awarded funding to enhance and maintain #R #Biostrings. We're looking forward to seeing what he can do for the #bioinformatics community.
April 29, 2024 at 12:50 PM
Cool new paper released from the lab: Many purported pseudogenes in bacterial genomes are bona fide genes! wrightlabscience.com/publications
April 19, 2024 at 5:43 PM
Hi All: We're looking for Post-Docs for our soggy lab for September. You don't have to already be a bioinformatician, as we are willing to train. We're especially interested in solving antibiotic resistance. Pls reach out w/ questions and share. We'd love to fill this position (we have 2). 🧪🖥️🧬
April 1, 2024 at 6:51 PM
GLBio24 is in Pittsburgh this year! Submissions are open! Submit to our "Big Biological Data" Special Session! 🧪
January 31, 2024 at 6:02 PM
Now that Spotify Wrapped has wrapped. Let's check out the Wright Lab Year In Review! 🧪
January 12, 2024 at 3:47 PM
Turns out that popular AI suggests us not once, but 3 times for the same query on sequence alignments. www.wrightlabscience.com/index.html
Wright Lab
www.wrightlabscience.com
November 9, 2023 at 3:49 PM
We're the Wright Lab at the University of Pittsburgh School of Medicine. We do evolution of antibiotic resistance in a 'soggy' (both dry and wet lab work) lab. Our under-construction website: www.wrightlabscience.com/p/index.html. We also have available T15 funding!
October 3, 2023 at 6:13 PM
Our department is recruiting PhD students for the 2024 cohort! Come work with us in biomedical informatics. Our lab works on solutions to antibiotic resistance using computational methods. 🧪🧫🩺
September 20, 2023 at 1:50 PM
Hi! can we be added to the what's science feed/bioinformatics? @danirabaiotti.bsky.social (Also, thanks for curating!) 🧪. 🖥️ 🧬
September 11, 2023 at 4:44 PM
Are you an undergrad looking for a grad program in the bioinformatics space? Are you interested in new, evolving problems in antibiotic resistance? We have funding. Come work with us! 🧪
September 11, 2023 at 3:00 PM