Katharina Lichter
@klichter.bsky.social
Synaptic Physiologist & MD. PostDoc with P. Jonas @istaresearch.bsky.social Investigates nanoscopic structure-function of synapses. Dedicated to hippocampus, bicycles & mountains.
Reposted by Katharina Lichter
Kiss, shrink, run | Science www.science.org/doi/10.1126/...
Kiss, shrink, run
A unified mechanism directs synaptic vesicle release
www.science.org
October 18, 2025 at 3:23 PM
Kiss, shrink, run | Science www.science.org/doi/10.1126/...
Kiss, Shrink, Run ⛹🏻♀️ New Perspective in @science.org about one of my favourite topics: how synapses and their tiny vesicles communicate in the brain. Chang-Lu Tao and colleagues reveal a previously unknown pathway for vesicle release. Read more here: doi.org/10.1126/scie... @istaresearch.bsky.social
Kiss, shrink, run
A unified mechanism directs synaptic vesicle release
doi.org
October 19, 2025 at 1:46 PM
Kiss, Shrink, Run ⛹🏻♀️ New Perspective in @science.org about one of my favourite topics: how synapses and their tiny vesicles communicate in the brain. Chang-Lu Tao and colleagues reveal a previously unknown pathway for vesicle release. Read more here: doi.org/10.1126/scie... @istaresearch.bsky.social
Reposted by Katharina Lichter
We are delighted and very satisfied with a extremely smooth installation of the @abberior.rocks Mirava Polyscope, by 2 fantastic engineers. Our new ‘imaging soldier’ is equipped with 2- and 3D STED, MINDLUX, adaptive optics, lifetime imaging, matrix detectors and options for spectral imaging.
August 27, 2025 at 2:55 PM
We are delighted and very satisfied with a extremely smooth installation of the @abberior.rocks Mirava Polyscope, by 2 fantastic engineers. Our new ‘imaging soldier’ is equipped with 2- and 3D STED, MINDLUX, adaptive optics, lifetime imaging, matrix detectors and options for spectral imaging.
Outstanding work by my colleague @jakefwatson.bsky.social on heterogeneous CA3 PNs in the mouse hippocampus. Check it out!
Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...
Cell-specific wiring routes information flow through hippocampal CA3
The hippocampus, critical for learning and memory, is dogmatically described as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyr…
www.sciencedirect.com
August 2, 2025 at 2:47 PM
Outstanding work by my colleague @jakefwatson.bsky.social on heterogeneous CA3 PNs in the mouse hippocampus. Check it out!
Reposted by Katharina Lichter
Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...
Cell-specific wiring routes information flow through hippocampal CA3
The hippocampus, critical for learning and memory, is dogmatically described as a trisynaptic circuit where dentate gyrus granule cells (GCs), CA3 pyr…
www.sciencedirect.com
August 2, 2025 at 2:25 PM
Our work looking into heterogeneous pyramidal neurons (PNs) in hippocampal CA3 is now online @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti... With a pile of multicellular recordings from mouse CA3, we characterised the recurrent network at the single cell level...
Reposted by Katharina Lichter
Reposted by Katharina Lichter
The @erc.europa.eu awards Advanced Grants to “active researchers who have a track-record of significant research achievements.” ISTA could now secure a quadruple success in the most recent call for these prestigious European grants. #ERCAdG
June 17, 2025 at 10:03 AM
The @erc.europa.eu awards Advanced Grants to “active researchers who have a track-record of significant research achievements.” ISTA could now secure a quadruple success in the most recent call for these prestigious European grants. #ERCAdG
Reposted by Katharina Lichter
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Memory by a thousand rules: Automated discovery of functional multi-type plasticity rules reveals variety & degeneracy at the heart of learning
Synaptic plasticity is the basis of learning and memory, but the link between synaptic changes and neural function remains elusive. Here, we used automated search algorithms to obtain thousands of str...
www.biorxiv.org
June 2, 2025 at 6:50 PM
We just pushed “Memory by a 1000 rules” onto bioRxiv, where we use clever #ML to find #plasticity quadruplets (EE, EI, IE, II) that learn basic stability in spiking nets. Why is it cool? We find 1000s!! of solutions, and they don’t just stabilise. They #memorise! www.biorxiv.org/content/10.1...
Reposted by Katharina Lichter
Curious about the latest news on how RGP lineages generate cortical neuronal diversity? Don't miss our new review from @HippenmeyerLab written by @fabripipicelli.bsky.social and myself www.sciencedirect.com/science/arti...
How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex
The cerebral cortex is arguably the most complex organ in humans. The cortical architecture is characterized by a remarkable diversity of neuronal and…
www.sciencedirect.com
May 22, 2025 at 7:24 PM
Curious about the latest news on how RGP lineages generate cortical neuronal diversity? Don't miss our new review from @HippenmeyerLab written by @fabripipicelli.bsky.social and myself www.sciencedirect.com/science/arti...
Reposted by Katharina Lichter
www.sciencedirect.com/science/arti...
Our new review in Current Opinion in Neurobiology is out! "How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex"
Our new review in Current Opinion in Neurobiology is out! "How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex"
How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex
The cerebral cortex is arguably the most complex organ in humans. The cortical architecture is characterized by a remarkable diversity of neuronal and…
www.sciencedirect.com
May 20, 2025 at 12:00 PM
www.sciencedirect.com/science/arti...
Our new review in Current Opinion in Neurobiology is out! "How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex"
Our new review in Current Opinion in Neurobiology is out! "How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex"
Reposted by Katharina Lichter
🔬 Ever wondered how therapeutic antibodies work?
3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies.
📄 Read more: www.science.org/doi/10.1126/...
3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies.
📄 Read more: www.science.org/doi/10.1126/...
January 10, 2025 at 9:00 AM
🔬 Ever wondered how therapeutic antibodies work?
3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies.
📄 Read more: www.science.org/doi/10.1126/...
3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies.
📄 Read more: www.science.org/doi/10.1126/...
Reposted by Katharina Lichter
New brain aging study is out today in Nature
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
January 1, 2025 at 5:07 PM
New brain aging study is out today in Nature
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN
Reposted by Katharina Lichter
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
December 26, 2024 at 5:31 PM
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Reposted by Katharina Lichter
Researchers challenged longhorn crazy ants and humans with the same task: maneuvering a T-shaped object through two consecutive open doorways. Single humans always outperformed single ants, but ant groups could beat human groups. In PNAS: www.pnas.org/doi/10.1073/...
December 27, 2024 at 9:03 PM
Researchers challenged longhorn crazy ants and humans with the same task: maneuvering a T-shaped object through two consecutive open doorways. Single humans always outperformed single ants, but ant groups could beat human groups. In PNAS: www.pnas.org/doi/10.1073/...
Reposted by Katharina Lichter
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
www.nature.com
December 18, 2024 at 10:00 PM
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Reposted by Katharina Lichter
Axonal and synaptic mechanisms in the HUMAN neocortex that could underlie memory consolidation during slow-wave #sleep . Check out our latest research published today in Nature Communications ( @natureportfolio.bsky.social ). 🎉
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
December 12, 2024 at 6:46 PM
Axonal and synaptic mechanisms in the HUMAN neocortex that could underlie memory consolidation during slow-wave #sleep . Check out our latest research published today in Nature Communications ( @natureportfolio.bsky.social ). 🎉
Link: www.nature.com/articles/s41...
Link: www.nature.com/articles/s41...
Reposted by Katharina Lichter
Want to know how many vesicles there are in a mossy fibre synapse, without counting thousands of vesicles by hand in electron micrographs?
Our new tool SynapseNet has you covered and is now available as a preprint www.biorxiv.org/content/10.1... .
Read on for a short overview of our paper.
Our new tool SynapseNet has you covered and is now available as a preprint www.biorxiv.org/content/10.1... .
Read on for a short overview of our paper.
December 6, 2024 at 3:39 PM
Want to know how many vesicles there are in a mossy fibre synapse, without counting thousands of vesicles by hand in electron micrographs?
Our new tool SynapseNet has you covered and is now available as a preprint www.biorxiv.org/content/10.1... .
Read on for a short overview of our paper.
Our new tool SynapseNet has you covered and is now available as a preprint www.biorxiv.org/content/10.1... .
Read on for a short overview of our paper.
Reposted by Katharina Lichter
Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few
Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory
Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.
www.cell.com
December 11, 2024 at 7:46 PM
Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few
Outstanding project by our lab and foremost by my super talented colleague @jakefwatson.bsky.social - check it out!!!
Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few
Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory
Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.
www.cell.com
December 11, 2024 at 8:39 PM
Outstanding project by our lab and foremost by my super talented colleague @jakefwatson.bsky.social - check it out!!!