Kristiina Kanerva
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Kristiina Kanerva
@kkanerva.bsky.social
5 followers 9 following 1 posts
PhD • University Researcher in Elina Ikonen lab @helsinki.fi
I ❤️🔬 interested in lipid trafficking, microscopy and cell biology of cholesterol
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Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex | Science www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 10, 2025 at 10:41 AM
Reposted by Kristiina Kanerva
science.org
Fat storage in the body relies on specialized structures called lipid droplets. In a new Science study, researchers identified the microprotein adipogenin as a regulator of adipocyte lipid droplet size, revealing a key mechanism in lipid homeostasis.

Learn more this week: https://scim.ag/4nFEGO7
Lipid droplet growth is orchestrated by the seipin complex, which provides a structural platform for droplet nucleation and expansion. The microprotein adipogenin fine-tunes seipin’s conformation, remodeling its architecture to regulate lipid storage capacity. This modulation results in the formation of fewer but larger lipid droplets, revealing a key mechanism in lipid homeostasis.
November 6, 2025 at 7:05 PM