Kasimir Kienbeck
@kienbeck.bsky.social
Interested in molecular mechanisms of small #ribozymes | #PhD in #Chemistry in the Sigel Lab @ UZH | new to #Cryo-EM | #RNA
Reposted by Kasimir Kienbeck
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
November 6, 2025 at 8:30 AM
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
Reposted by Kasimir Kienbeck
Phage people: Rich Losick and I are combing the world looking for T4 rIIB mutant FC0 (also known as P13). FC0 was the starting point for Francis Crick's beautiful 1961 paper on the triplet nature of the genetic code. We want to sequence it. Anyone have it in an ancient stock collection?
June 1, 2025 at 2:46 PM
Phage people: Rich Losick and I are combing the world looking for T4 rIIB mutant FC0 (also known as P13). FC0 was the starting point for Francis Crick's beautiful 1961 paper on the triplet nature of the genetic code. We want to sequence it. Anyone have it in an ancient stock collection?
May 30, 2025 at 4:03 PM
Looking forward to the 30th Annual Meeting of The @rnasociety.bsky.social starting tomorrow! Join Concurrent Session 15 on Saturday at 3:30 PM to hear my talk on Theta Ribozymes!
May 27, 2025 at 3:40 AM
Looking forward to the 30th Annual Meeting of The @rnasociety.bsky.social starting tomorrow! Join Concurrent Session 15 on Saturday at 3:30 PM to hear my talk on Theta Ribozymes!
Reposted by Kasimir Kienbeck
Did you know that some phages can switch genetic codes during infection via the use of suppressor tRNAs? 🧬
One year ago we identified a ribozyme group which appears to be crucial for this process!
Read the original article: rdcu.be/dANOT
Or the press release: shorturl.at/7UPFX
@kienbeck.bsky.social
One year ago we identified a ribozyme group which appears to be crucial for this process!
Read the original article: rdcu.be/dANOT
Or the press release: shorturl.at/7UPFX
@kienbeck.bsky.social
March 24, 2025 at 2:29 PM
Did you know that some phages can switch genetic codes during infection via the use of suppressor tRNAs? 🧬
One year ago we identified a ribozyme group which appears to be crucial for this process!
Read the original article: rdcu.be/dANOT
Or the press release: shorturl.at/7UPFX
@kienbeck.bsky.social
One year ago we identified a ribozyme group which appears to be crucial for this process!
Read the original article: rdcu.be/dANOT
Or the press release: shorturl.at/7UPFX
@kienbeck.bsky.social
Reposted by Kasimir Kienbeck
🚨 PhD Opportunity!
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
March 17, 2025 at 10:41 AM
🚨 PhD Opportunity!
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Reposted by Kasimir Kienbeck
And this is why we do RNA research. Credit: The incredible xkcd. xkcd.com/3056/
March 13, 2025 at 6:11 AM
And this is why we do RNA research. Credit: The incredible xkcd. xkcd.com/3056/
Reposted by Kasimir Kienbeck
Hello bluesky! The SigelLab is now also here, we are looking forward to good science, fascinating stories and good discussions!
This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.
This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.
February 25, 2025 at 7:16 AM
Hello bluesky! The SigelLab is now also here, we are looking forward to good science, fascinating stories and good discussions!
This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.
This account is - as was our X/Twitter account - managed by Ph.D. students or PostDocs in our lab, not Prof. Roland Sigel himself.
Reposted by Kasimir Kienbeck
Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available.
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme
Hydrophobicity controls many aspects of protein and enzyme function. Although hydrophobic tuning can be achieved to a limited extent with canonical amino acids, the incorporation of non- canonical ami...
www.biorxiv.org
February 11, 2025 at 9:28 AM
Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available.
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
Dear #Cryo-EM community,
Have you ever experienced electrostatic effects when handling grids? I have had my grids stick to the box lids multiple times now and was wondering if there is an easy fix. Any suggestions?
Have you ever experienced electrostatic effects when handling grids? I have had my grids stick to the box lids multiple times now and was wondering if there is an easy fix. Any suggestions?
December 31, 2024 at 6:09 AM
Dear #Cryo-EM community,
Have you ever experienced electrostatic effects when handling grids? I have had my grids stick to the box lids multiple times now and was wondering if there is an easy fix. Any suggestions?
Have you ever experienced electrostatic effects when handling grids? I have had my grids stick to the box lids multiple times now and was wondering if there is an easy fix. Any suggestions?
Can someone explain to me what a CUDA Core is like you would to a 10 year old?
December 4, 2024 at 5:14 AM
Can someone explain to me what a CUDA Core is like you would to a 10 year old?
I froze my very first grids back in Switzerland today 🥳 wish me luck, I'm screening on Friday the 13th...
November 28, 2024 at 8:03 PM
I froze my very first grids back in Switzerland today 🥳 wish me luck, I'm screening on Friday the 13th...
Describe your current state with a song name, I'll start:
Down with the Sickness by Disturbed
Down with the Sickness by Disturbed
November 21, 2024 at 7:55 AM
Describe your current state with a song name, I'll start:
Down with the Sickness by Disturbed
Down with the Sickness by Disturbed
Today I learned that pET expression vectors have some design flaws and fixing them can increase yield several tenfolds! Crazy how we rely on systems that "ain't broke so why fix them" for decades without questioning them. Does this bother you as well or am I just a hopeless perfectionist?
November 18, 2024 at 5:18 PM
Today I learned that pET expression vectors have some design flaws and fixing them can increase yield several tenfolds! Crazy how we rely on systems that "ain't broke so why fix them" for decades without questioning them. Does this bother you as well or am I just a hopeless perfectionist?
Time to properly introduce myself 👋
We found some interesting small catalytic RNAs in human gut phages - theta ribozymes. We think they might contribute to tRNA-mediated host manipulation via alternative genetic codes. Read more here: www.nature.com/articles/s41...
1/2
We found some interesting small catalytic RNAs in human gut phages - theta ribozymes. We think they might contribute to tRNA-mediated host manipulation via alternative genetic codes. Read more here: www.nature.com/articles/s41...
1/2
Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages - Nature Communications
The diverse functional roles of ribozymes (RNAs with enzymatic activity) continue to be uncovered. Here, the authors identify and characterize a subgroup of minimal hepatitis delta virus (HDV)-like ri...
www.nature.com
November 15, 2024 at 5:16 AM
Time to properly introduce myself 👋
We found some interesting small catalytic RNAs in human gut phages - theta ribozymes. We think they might contribute to tRNA-mediated host manipulation via alternative genetic codes. Read more here: www.nature.com/articles/s41...
1/2
We found some interesting small catalytic RNAs in human gut phages - theta ribozymes. We think they might contribute to tRNA-mediated host manipulation via alternative genetic codes. Read more here: www.nature.com/articles/s41...
1/2
Hello world! (with a blue sky)
November 14, 2024 at 7:33 AM
Hello world! (with a blue sky)