How can Le Chatelier drive kinetics? @stefanborsley.bsky.social and I analyse Denton's organocatalytic Mitsunobu reaction and show water removal improvements outperform catalyst redesigns. Why? Removing water part way through the reaction resets the potential energy surface! doi.org/10.1021/jacs...

Keith Andrews @keithandrews.bsky.social from Durham University @durham-university.bsky.social highlights some of the key advances in traditional #CavityCatalysis:
➡️ https://www.beilstein-journals.org/bjoc/articles/21/30?B=y

#EnzymeMimics #SupramolecularCatalysis
💎🔓 #BJOC

Out now, and just in time for my first #chemsky post: my perspective on the emerging field of Robust Organic Cages as catalysts and enzyme mimics, including an overview of our contributions so far – doi.org/10.3762/bjoc...

A really fun project, delivered on the back of Peng-Lai’s fantastic efforts, ably assisted by Martin and of course our collaborators in Strasbourg, Alessandro and @giusepponelab.bsky.social, who taught us lots of polymer and materials chemistry.

Thanks all!

Peng-Lai, @stefanborsley.bsky.social, Martin & our collaborators Alessandro and @giusepponelab.bsky.social demonstrate how a catalyst transduces chemical energy to perform mechanical work in www.nature.com/articles/s41... in @nature.com. tinyurl.com/jny7nen5. Animation @scicommstudios.bsky.social😀