Excited to share the work of our PhD candidate, Leah Keiser. Leah engineered polyketide synthases (PKSs) to control stereochemistry. By systematically exchanging domains, her work provides insights into the biosynthesis of complex molecules with tunable stereocenters 👩‍🔬🧪 pubs.acs.org/doi/full/10....

If you want to do single or multi-mutant protein optimization with a (very) small amount of data and a laptop, check out our recent work FolDE (github.com/JBEI/foldy)!

Open platform with a super nice, intuitive UI! Led by @jacoberts.bsky.social at @keaslinglab.bsky.social.

We're excited to share FolDE, a low-N protein optimization method. In simulation, we found that FolDE is 55% more likely to identify top-1% hits than current baseline methods. FolDE is open and can be set up on a personal computer with a single command.
arxiv.org/abs/2510.24053