Katherina Siewert
@katherinasiewert.bsky.social
Immunologist, T cells, allergy
~Head of Dermatotoxicology Study Centre at the German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Born@340 ppm; she/her
~Head of Dermatotoxicology Study Centre at the German Federal Institute for Risk Assessment (BfR), Berlin, Germany
Born@340 ppm; she/her
Reposted by Katherina Siewert
TCR specificity can be hard to understand. See our latest work showing how dynamic allostery in a peptide/MHC complex can control TCR specificity towards a public neoantigen. Great collaboration with Chris Klebanoff and team at @mskcancercenter.bsky.social #immunosky
doi.org/10.1038/s414...
1/7
doi.org/10.1038/s414...
1/7
Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity - Nature Communications
While static structures can provide insight into T cell receptor (TCR) antigen specificity, this often fails and auxiliary information is needed. Here the authors show, by focusing on an HLA-A3-bound ...
doi.org
January 20, 2025 at 8:31 PM
TCR specificity can be hard to understand. See our latest work showing how dynamic allostery in a peptide/MHC complex can control TCR specificity towards a public neoantigen. Great collaboration with Chris Klebanoff and team at @mskcancercenter.bsky.social #immunosky
doi.org/10.1038/s414...
1/7
doi.org/10.1038/s414...
1/7
Reposted by Katherina Siewert
Disease prevalence in US states before & after vaccine introduction
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
November 15, 2024 at 5:00 AM
Disease prevalence in US states before & after vaccine introduction
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
Graphic from Edward Tufte
More graphics.wsj.com/infectious-d... 🧪
We are interested in metal-specific TCRs:
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Unique and common TCR repertoire features of Ni2+‐, Co2+‐, and Pd2+‐specific human CD154 + CD4+ T cells
Ni2+-, Co2+-, and Pd2+-specific CD4+ T cells can be detected by a short-term CD154 upregulation assay. Overrepresentation of certain individual gene segments or a CDR3 histidine represent distinct TC...
onlinelibrary.wiley.com
November 16, 2024 at 10:32 AM
We are interested in metal-specific TCRs:
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....