🧪Korean Red Ginseng extract (RGE) fights H9N2 flu 🦠but may boost H1N1 in some lung cells 🔄Cell-type matters: effects vary by virus & treatment mode 🎯 Potential for targeted antiviral use. 🔗 https://t.co/XrNpJM54Rs #Ginseng #Influenza #Antiviral #PrecisionMedicine #Virology

Thu. Mar 27, 2025 1:00 PM - 3:40 PM JST The 105th CSJ Annual Meeting

Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplor...

Target protein degradation (TPD) is a promising strategy for catalytic downregulation of target proteins through various cellular proteolytic pathways. Despite numerous reports on novel TPD mechanisms, the discovery of target-specific ligands remains a major challenge. Unlike small-molecule ligands, aptamers offer significant advantages, owing to their SELEX-based systematic screening method. To fully utilize aptamers for TPD, we designed an aptamer and N-degron ensemble system (AptaGron) that circumvents the need for synthetic conjugations between aptamers and proteolysis-recruiting units. In our AptaGron system, a peptide nucleic acid containing an N-degron peptide and a sequence complementary to the aptamer was designed. Using this system, we successfully degraded three target proteins, tau, nucleolin, and eukaryotic initiation factor 4E (eIF4E), which lack specific small-molecule ligands. Our results highlight the potential of the AptaGron approach as a robust platform for targeted protein degradation.