@juliusbogo.bsky.social
Pinned
Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N - Communications Biology
Development of genetically encoded fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane and demonstrating a new approach for...
go.nature.com
Excited to share our new paper on a PKN biosensor—and how to build more! We only have a handful of kinase biosensors out there; now that ExRai backbone @jinzhanglab “anything you can do I can do better” for excising sensors real bottleneck is finding new substrates. go.nature.com/42rUgpO
It was fun distraction to participate International Cherry Blossom Prediction Competition organized by @georgemasonu.bsky.social. Not the winner, but not shabby for a first try.
jbogomolovas2.github.io/Julius-s-Blo...
jbogomolovas2.github.io/Julius-s-Blo...
Cherry Bloom Prediction – Julius’s Blog
Data Science, Swimming Analytics, and R Programming
jbogomolovas2.github.io
July 8, 2025 at 9:10 AM
It was fun distraction to participate International Cherry Blossom Prediction Competition organized by @georgemasonu.bsky.social. Not the winner, but not shabby for a first try.
jbogomolovas2.github.io/Julius-s-Blo...
jbogomolovas2.github.io/Julius-s-Blo...
Reposted
Our new paper in @commsbio.bsky.social. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes —even through mitosis and nuclear envelope breakdown—overcoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Intronic RNAscope probes enable precise identification of cardiomyocyte nuclei and cell cycle activity - Communications Biology
Intronic RNA probes precisely identify cardiomyocyte nuclei or chromatin throughout the cell cycle during embryonic cardiomyocyte proliferation and precisely identify cardiomyocyte nuclei in adult hea...
www.nature.com
April 10, 2025 at 10:06 PM
Our new paper in @commsbio.bsky.social. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes —even through mitosis and nuclear envelope breakdown—overcoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Our new paper in @commsbio.bsky.social. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes —even through mitosis and nuclear envelope breakdown—overcoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Intronic RNAscope probes enable precise identification of cardiomyocyte nuclei and cell cycle activity - Communications Biology
Intronic RNA probes precisely identify cardiomyocyte nuclei or chromatin throughout the cell cycle during embryonic cardiomyocyte proliferation and precisely identify cardiomyocyte nuclei in adult hea...
www.nature.com
April 10, 2025 at 10:06 PM
Our new paper in @commsbio.bsky.social. We show that Tnnt2 intronic RNAscope probe reliably identifies cardiomyocytes —even through mitosis and nuclear envelope breakdown—overcoming the limitations of traditional CM identification methods.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Our paper on #ALPK3 is out in JAHA.
We demonstrate that loss of ALPK3 and established factor for genetic cardiomyopathy leads to accumulation of thick filament components, possibly via MuRFs - muscle specific E3 ubiquitin ligases.
doi.org/10.1161/JAHA...
We demonstrate that loss of ALPK3 and established factor for genetic cardiomyopathy leads to accumulation of thick filament components, possibly via MuRFs - muscle specific E3 ubiquitin ligases.
doi.org/10.1161/JAHA...
α Protein Kinase 3 Is Essential for Neonatal and Adult Cardiac Function | Journal of the American Heart Association
doi.org
April 7, 2025 at 3:12 PM
Our paper on #ALPK3 is out in JAHA.
We demonstrate that loss of ALPK3 and established factor for genetic cardiomyopathy leads to accumulation of thick filament components, possibly via MuRFs - muscle specific E3 ubiquitin ligases.
doi.org/10.1161/JAHA...
We demonstrate that loss of ALPK3 and established factor for genetic cardiomyopathy leads to accumulation of thick filament components, possibly via MuRFs - muscle specific E3 ubiquitin ligases.
doi.org/10.1161/JAHA...
New work on how and when Indo-europeans emerged.
Nice to see how Marijas Gimbutas Kurgan hypothesis has been verified using ancient DNA approach and new insights and details obtained.
Nice to see how Marijas Gimbutas Kurgan hypothesis has been verified using ancient DNA approach and new insights and details obtained.
Our papers, out today in @nature.com, show how ancient DNA from the Eneolithic and Bronze Age steppe points to a North Pontic origin of the Indo-European language family and a Caucasus-Lower Volga (CLV) origin of Indo-Anatolian (inclusive of the now extinct Anatolian languages). 1/
February 7, 2025 at 6:52 AM
New work on how and when Indo-europeans emerged.
Nice to see how Marijas Gimbutas Kurgan hypothesis has been verified using ancient DNA approach and new insights and details obtained.
Nice to see how Marijas Gimbutas Kurgan hypothesis has been verified using ancient DNA approach and new insights and details obtained.
Very likely successful cloning of HDR template for knock-in (ccdB present in source plasmid, sequencing pending). Still got the cloning touch! 🧬 #KeepCalmAndCarryOn
February 2, 2025 at 11:20 PM
Very likely successful cloning of HDR template for knock-in (ccdB present in source plasmid, sequencing pending). Still got the cloning touch! 🧬 #KeepCalmAndCarryOn
Reposted
Hey Bluesky! If you're an Addgene fan, you might want to sign up for our quarterly newsletter. Each edition contains the latest Addgene news, hot plasmids, new viral vectors, and a coupon. Click the link below to browse old editions and join our mailing list!
www.addgene.org/news...
www.addgene.org/news...
Addgene: Newsletters from Addgene
Read Addgene's quarterly newsletters which include information on the latest molecular biology techniques, articles, and plasmids in our collection.
www.addgene.org
January 27, 2025 at 7:30 PM
Hey Bluesky! If you're an Addgene fan, you might want to sign up for our quarterly newsletter. Each edition contains the latest Addgene news, hot plasmids, new viral vectors, and a coupon. Click the link below to browse old editions and join our mailing list!
www.addgene.org/news...
www.addgene.org/news...
Small but mighty .🐦🔥
January 25, 2025 at 1:32 AM
Small but mighty .🐦🔥
Excited to share our new paper on a PKN biosensor—and how to build more! We only have a handful of kinase biosensors out there; now that ExRai backbone @jinzhanglab “anything you can do I can do better” for excising sensors real bottleneck is finding new substrates. go.nature.com/42rUgpO
Illuminating understudied kinases: a generalizable biosensor development method applied to protein kinase N - Communications Biology
Development of genetically encoded fluorescent biosensor allows real-time visualization of PKN kinase activity, revealing sustained activity at the plasma membrane and demonstrating a new approach for...
go.nature.com
January 24, 2025 at 6:48 PM
Excited to share our new paper on a PKN biosensor—and how to build more! We only have a handful of kinase biosensors out there; now that ExRai backbone @jinzhanglab “anything you can do I can do better” for excising sensors real bottleneck is finding new substrates. go.nature.com/42rUgpO