@jrgreenland.bsky.social
What is the link between biological #aging and #frailty? In a lung transplant cohort, we found anemia and #telomere dysfunction were more linked to frailty than epigenetic age. www.sciencedirect.com/science/arti...
Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age
Frailty is a syndrome of vulnerability to stressors linked to worse outcomes before and after lung transplantation. However, the biological basis of t…
www.sciencedirect.com
May 21, 2025 at 8:39 PM
What is the link between biological #aging and #frailty? In a lung transplant cohort, we found anemia and #telomere dysfunction were more linked to frailty than epigenetic age. www.sciencedirect.com/science/arti...
Reposted
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
May 18, 2025 at 10:44 PM
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
Reposted
How to define AMR and ACR in #lungtransplantation ? Standing room only at #ISHLT Acute Lung Allograft Dysfunction suggests that many share this question ! @ishlt.bsky.social #transplantresearch
April 29, 2025 at 6:02 PM
How to define AMR and ACR in #lungtransplantation ? Standing room only at #ISHLT Acute Lung Allograft Dysfunction suggests that many share this question ! @ishlt.bsky.social #transplantresearch
Best papers from the JHLT at #ISHLT2025. ScRNAseq analysis of BAL in ALAD was the most downloaded. Can cells be used to prognosticate FEV1 decline? @jhlt.bsky.social @ishlt.bsky.social
April 28, 2025 at 12:48 PM
Best papers from the JHLT at #ISHLT2025. ScRNAseq analysis of BAL in ALAD was the most downloaded. Can cells be used to prognosticate FEV1 decline? @jhlt.bsky.social @ishlt.bsky.social
@ishlt.bsky.social Single cell sequencing in ALAD. Hot of the presses in @jhlt.bsky.social. Come see it at the Caves awards today. www.sciencedirect.com/science/arti...
Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways
Acute lung allograft dysfunction (ALAD) is a clinical syndrome of forced expiratory volume in 1-second (FEV1) decline concerning for chronic lung allo…
www.sciencedirect.com
April 28, 2025 at 11:12 AM
@ishlt.bsky.social Single cell sequencing in ALAD. Hot of the presses in @jhlt.bsky.social. Come see it at the Caves awards today. www.sciencedirect.com/science/arti...
@ishlt.bsky.social Sunday’s telomere session filled with advice on what to look out for in STS transplant: MDS, liver, CMV, EBV, AMR, oh my. www.frontiersin.org/journals/tra...
Frontiers | Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients
While chronologic age can be precisely defined, clinical manifestations of advanced age occur in different ways and at different rates across individuals. Th...
www.frontiersin.org
April 28, 2025 at 11:00 AM
@ishlt.bsky.social Sunday’s telomere session filled with advice on what to look out for in STS transplant: MDS, liver, CMV, EBV, AMR, oh my. www.frontiersin.org/journals/tra...
Reposted
Certainly greater challenges to manage after txp - transfusion needs 🩸, CMV risk 🦠, cancer by PTLD 🦀, airway issues 🫁). But novel and proactive strategies may help (?androgens, ?⬇️ immunosuppression). Lung txp 🫁♻️ saves & improves lives in 🫁 disease, telomere issues or not! ~ Dr. Tokman (Norton AZ)
April 27, 2025 at 3:06 PM
Certainly greater challenges to manage after txp - transfusion needs 🩸, CMV risk 🦠, cancer by PTLD 🦀, airway issues 🫁). But novel and proactive strategies may help (?androgens, ?⬇️ immunosuppression). Lung txp 🫁♻️ saves & improves lives in 🫁 disease, telomere issues or not! ~ Dr. Tokman (Norton AZ)
The immune response to CMV can be good and bad for #transplant recipients. Here, we identified T cells associated with effective CMV control. www.sciencedirect.com/science/arti...
Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation
Cytomegalovirus (CMV) infection threatens outcomes across solid organ transplantation, but organ-specific differences in CMV immunity are incompletely…
www.sciencedirect.com
March 21, 2025 at 3:42 PM
The immune response to CMV can be good and bad for #transplant recipients. Here, we identified T cells associated with effective CMV control. www.sciencedirect.com/science/arti...
Reposted
NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com
February 8, 2025 at 2:35 PM
NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
www.washingtonpost.com/health/2025/...
Reposted
Important paper from @MorriseyLab @ScienceMagazine advances our understanding of lung regeneration. #mustread! "An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung www.science.org/doi/abs/10.1...
An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this “stem cell collision” generates an injury-induced ti...
www.science.org
December 21, 2024 at 11:55 AM
Important paper from @MorriseyLab @ScienceMagazine advances our understanding of lung regeneration. #mustread! "An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung www.science.org/doi/abs/10.1...