Jordan Hamm
@jordanhamm.bsky.social
NYU and Nathan S. Kline Institute
neocortex, predictive processing, vision, oscillations, schizophrenia
Formerly -- Associate Prof @ GaStateU | postdoc @ Columbia | PhD @ UGA
lab website: jordanphamm.com
instagram: @ hammlab_nyu_nki
neocortex, predictive processing, vision, oscillations, schizophrenia
Formerly -- Associate Prof @ GaStateU | postdoc @ Columbia | PhD @ UGA
lab website: jordanphamm.com
instagram: @ hammlab_nyu_nki
Excited to share our preprint! Impressive effort from grad student Anna Rader Groves and co-author @cgalli-io.bsky.social, in collaboration with Melanie Grubisha and Robert Sweet (PITT). @grubisha
A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity https://www.biorxiv.org/content/10.64898/2026.01.28.702244v1
January 29, 2026 at 12:56 PM
Excited to share our preprint! Impressive effort from grad student Anna Rader Groves and co-author @cgalli-io.bsky.social, in collaboration with Melanie Grubisha and Robert Sweet (PITT). @grubisha
Excited to share our preprint! We show that primary visual cortex is modulated by global predictability. This effect depended on higher level brain region (area ACa), and better explained classic oddball paradigms better than “local” context effects (i.e., recent stimulus history). 1/3
Global context rapidly shapes sensory responses in V1 https://www.biorxiv.org/content/10.64898/2026.01.07.698143v1
January 8, 2026 at 7:26 PM
Excited to share our preprint! We show that primary visual cortex is modulated by global predictability. This effect depended on higher level brain region (area ACa), and better explained classic oddball paradigms better than “local” context effects (i.e., recent stimulus history). 1/3
Reposted by Jordan Hamm
Our new preprint is out!
We show that deviance detection in auditory cortex conveys the theorised comparison of internal prediction to sensory input. Our data confirm this key assumtion that links theoretical models of sensory processing to experimental data.
www.biorxiv.org/content/10.6...
We show that deviance detection in auditory cortex conveys the theorised comparison of internal prediction to sensory input. Our data confirm this key assumtion that links theoretical models of sensory processing to experimental data.
www.biorxiv.org/content/10.6...
Cortical deviance detection represents a canonical difference signal
Context modulates neural processing of sensory stimuli. Neural responses are suppressed to stimuli that are typical in their context and augmented to stimuli that deviate from their context. The latte...
www.biorxiv.org
January 7, 2026 at 4:30 PM
Our new preprint is out!
We show that deviance detection in auditory cortex conveys the theorised comparison of internal prediction to sensory input. Our data confirm this key assumtion that links theoretical models of sensory processing to experimental data.
www.biorxiv.org/content/10.6...
We show that deviance detection in auditory cortex conveys the theorised comparison of internal prediction to sensory input. Our data confirm this key assumtion that links theoretical models of sensory processing to experimental data.
www.biorxiv.org/content/10.6...
Mismatch negativity develops in adolescence and independently of microglia https://www.biorxiv.org/content/10.1101/2025.10.14.682114v1
October 16, 2025 at 3:31 PM
Reposted by Jordan Hamm
FYI…New York announced $10M in state funds for brain research. #neuroskyence #PsychSciSky
www.governor.ny.gov/news/governo...
www.governor.ny.gov/news/governo...
Governor Hochul Announces Launch of SUNY Brain Institute With $10 Million Investment to Fuel SUNY Excellence in Life-Saving Research
Governor Hochul announced a $10 million investment to launch the SUNY Brain Institute; a multi-campus initiative focused on expanding SUNY’s groundbreaking neuroscience research.
www.governor.ny.gov
October 12, 2025 at 2:11 PM
FYI…New York announced $10M in state funds for brain research. #neuroskyence #PsychSciSky
www.governor.ny.gov/news/governo...
www.governor.ny.gov/news/governo...
Reposted by Jordan Hamm
Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects https://www.biorxiv.org/content/10.1101/2025.08.14.670295v1
August 19, 2025 at 12:15 PM
Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects https://www.biorxiv.org/content/10.1101/2025.08.14.670295v1
Reposted by Jordan Hamm
Just learned that my @acnporg.bsky.social panel was accepted!
With my colleagues Zoë Hughes, @jordanhamm.bsky.social, Bryan Baxter & Patricio O'Donnell, our #ACNP2026 panel will highlight cross-species approaches using functional brain-based biomarkers to address translational gaps in psychiatry
With my colleagues Zoë Hughes, @jordanhamm.bsky.social, Bryan Baxter & Patricio O'Donnell, our #ACNP2026 panel will highlight cross-species approaches using functional brain-based biomarkers to address translational gaps in psychiatry
a group of people jumping off a cliff into a body of water with a caption that says colnah.cy
Alt: people jumping off a cliff into a body of water
media.tenor.com
August 12, 2025 at 5:12 PM
Just learned that my @acnporg.bsky.social panel was accepted!
With my colleagues Zoë Hughes, @jordanhamm.bsky.social, Bryan Baxter & Patricio O'Donnell, our #ACNP2026 panel will highlight cross-species approaches using functional brain-based biomarkers to address translational gaps in psychiatry
With my colleagues Zoë Hughes, @jordanhamm.bsky.social, Bryan Baxter & Patricio O'Donnell, our #ACNP2026 panel will highlight cross-species approaches using functional brain-based biomarkers to address translational gaps in psychiatry
First lab outing since the move to NYC.... feeling so lucky to have such a talented and fun group! with Lital Rachmany, @adhockley.bsky.social, me, Molly Hornick, Fumiyasu Imai, and @cgalli-io.bsky.social
August 5, 2025 at 5:08 PM
First lab outing since the move to NYC.... feeling so lucky to have such a talented and fun group! with Lital Rachmany, @adhockley.bsky.social, me, Molly Hornick, Fumiyasu Imai, and @cgalli-io.bsky.social
I’m delighted to congratulate Dr. Connor Gallimore for successfully defending his dissertation, “Patterns of laminar engagement during visual mismatch processing”. I consider myself lucky that Connor joined my lab in 2019. His CV, though impressive on its own, doesn’t even scratch the surface.
May 21, 2025 at 6:09 PM
I’m delighted to congratulate Dr. Connor Gallimore for successfully defending his dissertation, “Patterns of laminar engagement during visual mismatch processing”. I consider myself lucky that Connor joined my lab in 2019. His CV, though impressive on its own, doesn’t even scratch the surface.
Beautiful views and stimulating science discussion this week at University of Zurich/ETH Zurich with Wolfger von der Berhens, Fatih Yanık and many others. Honored to share my work with such a world class group!
April 13, 2025 at 9:49 AM
Beautiful views and stimulating science discussion this week at University of Zurich/ETH Zurich with Wolfger von der Berhens, Fatih Yanık and many others. Honored to share my work with such a world class group!
Reposted by Jordan Hamm
There are many studies on cell types and then there is the gold standard.
Beautiful work on the diversity of VIP interneurons by the Rudy lab!
#neuroskyence
www.biorxiv.org/content/10.1...
Beautiful work on the diversity of VIP interneurons by the Rudy lab!
#neuroskyence
www.biorxiv.org/content/10.1...
Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex
Cortical GABAergic interneurons (INs) are comprised of distinct types that provide tailored inhibition to pyramidal cells (PCs) and other INs, thereby enabling precise control of cortical circuit acti...
www.biorxiv.org
February 28, 2025 at 4:35 PM
There are many studies on cell types and then there is the gold standard.
Beautiful work on the diversity of VIP interneurons by the Rudy lab!
#neuroskyence
www.biorxiv.org/content/10.1...
Beautiful work on the diversity of VIP interneurons by the Rudy lab!
#neuroskyence
www.biorxiv.org/content/10.1...
I'm hiring a full-time research technician to work in my lab at Nathan Kline. Benefits included! Some lab experience preferred... experience with mouse surgeries a huge plus. If you live in NYC, there are two daily shuttles that take ≈20 min from upper manhattan. nki.applicantpro.com/jobs/3663631
Research Technician I (Emotional Brain Institute) (210-2025-06) - Orangeburg, NY
JOB DESCRIPTION:
The Emotional Brain Institute (EBI) is a multidisciplinary institute aimed at addressing fundamental questions in neuroscience and neuropsychiatry. We seek to hire a research technici...
nki.applicantpro.com
February 27, 2025 at 6:11 PM
I'm hiring a full-time research technician to work in my lab at Nathan Kline. Benefits included! Some lab experience preferred... experience with mouse surgeries a huge plus. If you live in NYC, there are two daily shuttles that take ≈20 min from upper manhattan. nki.applicantpro.com/jobs/3663631
New results from study of cortical thickness in 1211 psychosis cases and 734 controls demonstrates that "visual cortex is among the most profoundly affected brain regions", with effect sizes larger than prefrontal regions.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
February 16, 2025 at 9:22 PM
New results from study of cortical thickness in 1211 psychosis cases and 734 controls demonstrates that "visual cortex is among the most profoundly affected brain regions", with effect sizes larger than prefrontal regions.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Jordan Hamm
Press release of our new article in Neuron: How Does the Brain Differentiate New Stimuli From Old Ones? | Columbia News news.columbia.edu/news/how-doe...
How Does the Brain Differentiate New Stimuli From Old Ones?
A study sheds light on how networks in the brain detect new information, offering insight into disorders like schizophrenia.
news.columbia.edu
February 10, 2025 at 5:12 PM
Press release of our new article in Neuron: How Does the Brain Differentiate New Stimuli From Old Ones? | Columbia News news.columbia.edu/news/how-doe...
Our new paper is out in Neuron! We characterize auditory prediction errors across primary and secondary regions, to simple and complex stimuli. Deviance detection (and context) are distinct from basic adaptation -- even in a simple oddball paradigm. 1/2
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Slow cortical dynamics generate context processing and novelty detection
The cortex amplifies responses to novel stimuli while suppressing redundant ones. Novelty detection is necessary to efficiently process sensory inform…
www.sciencedirect.com
February 10, 2025 at 4:47 PM
Our new paper is out in Neuron! We characterize auditory prediction errors across primary and secondary regions, to simple and complex stimuli. Deviance detection (and context) are distinct from basic adaptation -- even in a simple oddball paradigm. 1/2
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jordan Hamm
Comment on our recent paper challenging the link between MMN dysfunction and positive symptoms:
www.sciencedirect.com/science/arti...
Thanks @mattnour.bsky.social
I may have missed it but cognitive map dysfunction is also unrelated to positive symptoms so far?
www.sciencedirect.com/science/arti...
Thanks @mattnour.bsky.social
I may have missed it but cognitive map dysfunction is also unrelated to positive symptoms so far?
If Mismatch Negativity Is the Answer, What Is the Question? On the Nature of Predictive Coding Abnormalities in Psychosis
www.sciencedirect.com
January 29, 2025 at 11:57 AM
Comment on our recent paper challenging the link between MMN dysfunction and positive symptoms:
www.sciencedirect.com/science/arti...
Thanks @mattnour.bsky.social
I may have missed it but cognitive map dysfunction is also unrelated to positive symptoms so far?
www.sciencedirect.com/science/arti...
Thanks @mattnour.bsky.social
I may have missed it but cognitive map dysfunction is also unrelated to positive symptoms so far?
www.nature.com/articles/s41...
Lots to unpack in this Nat Neuro paper on schiz genetics (ctx-wide GABA, amygdala, no DA?)
One thing: in terms of exc neurons, a vis-ctx specific cluster (133) and a ctx-wide cluster (123) is as implicated (if not, more) than the most prominent PFC cluster (404).
Lots to unpack in this Nat Neuro paper on schiz genetics (ctx-wide GABA, amygdala, no DA?)
One thing: in terms of exc neurons, a vis-ctx specific cluster (133) and a ctx-wide cluster (123) is as implicated (if not, more) than the most prominent PFC cluster (404).
Mapping the cellular etiology of schizophrenia and complex brain phenotypes - Nature Neuroscience
Duncan and colleagues link specific human brain cell types to schizophrenia and other complex brain phenotypes, providing mechanistic insights and a cellular taxonomy for psychiatric disorders.
www.nature.com
January 22, 2025 at 5:01 PM
www.nature.com/articles/s41...
Lots to unpack in this Nat Neuro paper on schiz genetics (ctx-wide GABA, amygdala, no DA?)
One thing: in terms of exc neurons, a vis-ctx specific cluster (133) and a ctx-wide cluster (123) is as implicated (if not, more) than the most prominent PFC cluster (404).
Lots to unpack in this Nat Neuro paper on schiz genetics (ctx-wide GABA, amygdala, no DA?)
One thing: in terms of exc neurons, a vis-ctx specific cluster (133) and a ctx-wide cluster (123) is as implicated (if not, more) than the most prominent PFC cluster (404).
Reposted by Jordan Hamm
One of the disappointing trends for urban college neighborhoods over the last few years is the introduction and maintenance of restrictions on access in and thru formerly open walkways.
So it's great to see efforts to protect these public easements.
www.nydailynews.com/2025/01/15/a...
So it's great to see efforts to protect these public easements.
www.nydailynews.com/2025/01/15/a...
Admission denied: Columbia must reopen its gates
This is an open letter to Columbia University Interim President Katrina Armstrong. Dear President Armstrong,
www.nydailynews.com
January 19, 2025 at 6:16 PM
One of the disappointing trends for urban college neighborhoods over the last few years is the introduction and maintenance of restrictions on access in and thru formerly open walkways.
So it's great to see efforts to protect these public easements.
www.nydailynews.com/2025/01/15/a...
So it's great to see efforts to protect these public easements.
www.nydailynews.com/2025/01/15/a...
Reposted by Jordan Hamm
New lab preprint ! There is a lot of excitement about the therapeutic potential of psilocybin but what is the mechanism? A beautiful body of work from @alexkwan.bsky.social shows that PFC plasticity is important. But how does this unfold and in which cell types?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 9, 2025 at 1:42 AM
New lab preprint ! There is a lot of excitement about the therapeutic potential of psilocybin but what is the mechanism? A beautiful body of work from @alexkwan.bsky.social shows that PFC plasticity is important. But how does this unfold and in which cell types?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jordan Hamm
Individuals with psychosis struggle with visual pattern integration, linked to altered brain activity and weakened connectivity in key visual areas, particularly during tasks involving background noise #Psychosis #MentalHealth #VisualPerception #Neuroscience #BrainConnectivity
Study links visual perception deficits in psychosis to altered brain connectivity
Individuals with psychosis struggle with visual pattern integration, linked to altered brain activity and weakened connectivity in key visual areas, particularly during tasks involving background noise
www.psypost.org
January 7, 2025 at 7:22 PM
Individuals with psychosis struggle with visual pattern integration, linked to altered brain activity and weakened connectivity in key visual areas, particularly during tasks involving background noise #Psychosis #MentalHealth #VisualPerception #Neuroscience #BrainConnectivity
We're all parts of institutions, and we're all vexed by seemingly pointless obstacles and bureaucracy at one point. Chesterton's fence provides a great lesson -- "Do not remove a fence until you know why it was constructed in the first place" #neuroskyence
fs.blog/chestertons-...
fs.blog/chestertons-...
Chesterton’s Fence: A Lesson in Thinking
A core component of making great decisions is understanding previous decisions. If we don’t understand how we got “here,” we run the risk of making things much worse.
fs.blog
December 17, 2024 at 4:40 PM
We're all parts of institutions, and we're all vexed by seemingly pointless obstacles and bureaucracy at one point. Chesterton's fence provides a great lesson -- "Do not remove a fence until you know why it was constructed in the first place" #neuroskyence
fs.blog/chestertons-...
fs.blog/chestertons-...
Reposted by Jordan Hamm
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Neuroscience
Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...
springernature.wd3.myworkdayjobs.com
December 9, 2024 at 3:36 PM
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions.
springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Reposted by Jordan Hamm
Here is a somber truth of creative life. If it goes well, people will begin to ask you for things. Each of those things, no matter how kind or flattering or genuine or even beneficial to your own career and finances as well as someone else's, will pull you from your true purpose.
December 5, 2024 at 10:04 PM
Here is a somber truth of creative life. If it goes well, people will begin to ask you for things. Each of those things, no matter how kind or flattering or genuine or even beneficial to your own career and finances as well as someone else's, will pull you from your true purpose.
Our book chapter is out!
Written for clinical researchers interested in translating neurophysiological biomarkers to rodent models
doi.org/10.1007/978-...
Written for clinical researchers interested in translating neurophysiological biomarkers to rodent models
doi.org/10.1007/978-...
Modern Methods for Unraveling Cell- and Circuit-Level Mechanisms of Neurophysiological Biomarkers in Psychiatry
Methods for studying the mammalian brain in vivo have advanced dramatically in the past two decades. State-of-the-art optical and electrophysiological techniques allow direct recordings of the functio...
doi.org
November 27, 2024 at 3:45 PM
Our book chapter is out!
Written for clinical researchers interested in translating neurophysiological biomarkers to rodent models
doi.org/10.1007/978-...
Written for clinical researchers interested in translating neurophysiological biomarkers to rodent models
doi.org/10.1007/978-...
Our spotlight article in Trends in Neurosciences is out!
We contextualize the recent findings by Furutachi, Hofer et al in the broader literature on V1 deviance detection and prediction error
www.sciencedirect.com/science/arti...
We contextualize the recent findings by Furutachi, Hofer et al in the broader literature on V1 deviance detection and prediction error
www.sciencedirect.com/science/arti...
An expanding repertoire of circuit mechanisms for visual prediction errors
Cortical responses to stimuli vary dependingon context and expectation. Adding insight into this process, Furutachi et al. recently demonstrated that …
www.sciencedirect.com
November 27, 2024 at 3:42 PM
Our spotlight article in Trends in Neurosciences is out!
We contextualize the recent findings by Furutachi, Hofer et al in the broader literature on V1 deviance detection and prediction error
www.sciencedirect.com/science/arti...
We contextualize the recent findings by Furutachi, Hofer et al in the broader literature on V1 deviance detection and prediction error
www.sciencedirect.com/science/arti...