John Parkhill
@johnparkhill.bsky.social
Senior director of machine learning @ Terray Therapeutics (https://www.terraytx.com/). Father. NSF CAREER award giver-upper. Gibe and gambol enjoyer. Refugee from https://x.com/j0hnparkhill. http://bbgky.net
Reposted by John Parkhill
As illustrated every damn day in this wannabe administration.
Hannah Arendt did not mince words, did she?
'Totalitarianism replaces all first-rate talents with crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.'
From "The Origins of Totalitarianism" (1951)
'Totalitarianism replaces all first-rate talents with crackpots and fools whose lack of intelligence and creativity is still the best guarantee of their loyalty.'
From "The Origins of Totalitarianism" (1951)
January 29, 2026 at 6:35 PM
As illustrated every damn day in this wannabe administration.
This is my new email signature.
January 28, 2026 at 10:56 PM
This is my new email signature.
Getting a 6mo lead in reading papers pre arxiv : priceless. Hilarious ppl are just taking the motivations for this naively.
openai.com/prism/
openai.com/prism/
Prism | A free, LaTeX-native workspace for scientists
Write, edit, and collaborate on scientific documents in LaTeX with Prism—a free workspace integrating GPT-5.2 into research and writing.
openai.com
January 28, 2026 at 2:06 PM
Getting a 6mo lead in reading papers pre arxiv : priceless. Hilarious ppl are just taking the motivations for this naively.
openai.com/prism/
openai.com/prism/
These are the chipotle slop bowl of science. -- Me at lunchtime.
January 27, 2026 at 5:57 PM
These are the chipotle slop bowl of science. -- Me at lunchtime.
Carb free sweetened beef is the telelogical endpoint of American civilization, and that goal is in sight.
arxiv.org/abs/2601.145...
arxiv.org/abs/2601.145...
De novo design of protein binders targeting the human sweet taste receptor as potential sweet proteins
Excessive consumption of dietary sugars is a major contributor to metabolic disorders, driving global interest in finding alternative sweeteners with reduced caloric impact. Natural sweet proteins, su...
arxiv.org
January 26, 2026 at 3:46 PM
Carb free sweetened beef is the telelogical endpoint of American civilization, and that goal is in sight.
arxiv.org/abs/2601.145...
arxiv.org/abs/2601.145...
It's 16 years after citizens united. If you want to resist the government what you do is sell US stock, treasuries and buy gold, and foreign stock. (really)
January 25, 2026 at 8:47 PM
It's 16 years after citizens united. If you want to resist the government what you do is sell US stock, treasuries and buy gold, and foreign stock. (really)
If you've actually managed to avoid holiday sickness by shifting hemispheres with your family this winter or sequestering. I wanna hear from you. HOW DID YOU DO IT.
January 18, 2026 at 7:20 PM
If you've actually managed to avoid holiday sickness by shifting hemispheres with your family this winter or sequestering. I wanna hear from you. HOW DID YOU DO IT.
It's basically impossible that Chat bot Ads will remain passive, because any competitor can do the agentic ads, and they will have a margin that is hundreds of times larger.
January 16, 2026 at 10:03 PM
It's basically impossible that Chat bot Ads will remain passive, because any competitor can do the agentic ads, and they will have a margin that is hundreds of times larger.
It's sade's birthday -- The real valentine's day for those who celebrate.
January 16, 2026 at 7:01 PM
It's sade's birthday -- The real valentine's day for those who celebrate.
My dread of holiday flights...
December 1, 2025 at 2:52 AM
My dread of holiday flights...
This is the way arxiv.org/abs/2506.044...
Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic...
arxiv.org
June 6, 2025 at 12:55 PM
This is the way arxiv.org/abs/2506.044...
Beautiful. arxiv.org/abs/2505.13447
Mean Flows for One-step Generative Modeling
We propose a principled and effective framework for one-step generative modeling. We introduce the notion of average velocity to characterize flow fields, in contrast to instantaneous velocity modeled...
arxiv.org
May 21, 2025 at 3:55 PM
Beautiful. arxiv.org/abs/2505.13447
I can't decide how I feel about someone vibecoding what is asked for in the job description. It shows initiative? But probably should have added "oh, don't put vibecode emoji's everywhere" to the system prompt.
May 7, 2025 at 9:46 PM
I can't decide how I feel about someone vibecoding what is asked for in the job description. It shows initiative? But probably should have added "oh, don't put vibecode emoji's everywhere" to the system prompt.
The persistence of docking in drug design has been explained. :P www.nature.com/articles/s41...
Using an algorithmic approach to shape human decision-making through attraction to patterns - Nature Communications
Here, using data from a competition between academic teams to influence decision-making, the authors show that people, intending to maximize their profit, prefer options delivering rewards in a discov...
www.nature.com
May 5, 2025 at 12:55 PM
The persistence of docking in drug design has been explained. :P www.nature.com/articles/s41...
gemini is pretty good at making manim animations with a little help, but boy without UV, manim would be impossible to install.
May 1, 2025 at 2:02 PM
gemini is pretty good at making manim animations with a little help, but boy without UV, manim would be impossible to install.
If you think we can avoid Thalidomide like outcomes without animal models today, you're an idiot. If you think you're merely marketing, you should appreciate that idiots will listen to you, and the consequences will be real. I will bet anyone 1000$ if this happens it ends poorly.
April 28, 2025 at 5:07 PM
If you think we can avoid Thalidomide like outcomes without animal models today, you're an idiot. If you think you're merely marketing, you should appreciate that idiots will listen to you, and the consequences will be real. I will bet anyone 1000$ if this happens it ends poorly.
The transition between "wins nobel prize" and "says vitamin C cures mortality" or "HIV doesn't cause AIDS" or "lobotomies for everyone" or "eugenics is cool" - or "disease is over because I interpolated crystal structures" is crazy short. (all utterances of nobel prize winners)
April 25, 2025 at 8:40 PM
The transition between "wins nobel prize" and "says vitamin C cures mortality" or "HIV doesn't cause AIDS" or "lobotomies for everyone" or "eugenics is cool" - or "disease is over because I interpolated crystal structures" is crazy short. (all utterances of nobel prize winners)
Only someone who can't think at 2nd order would ever take virtual cell models seriously without many unrelated breakthroughs. There are obvious, indisputable reasons they are stupid, and no one needs them more than me.
genomebiology.biomedcentral.com/articles/10....
Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.
Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.
Zero-shot evaluation reveals limitations of single-cell foundation models - Genome Biology
Foundation models such as scGPT and Geneformer have not been rigorously evaluated in a setting where they are used without any further training (i.e., zero-shot). Understanding the performance of mode...
genomebiology.biomedcentral.com
April 20, 2025 at 9:30 PM
Only someone who can't think at 2nd order would ever take virtual cell models seriously without many unrelated breakthroughs. There are obvious, indisputable reasons they are stupid, and no one needs them more than me.
If your field is getting more "perspectives" papers or "position" papers, you're going to get feudalism and dreck. I'd hop :)
April 18, 2025 at 5:53 PM
If your field is getting more "perspectives" papers or "position" papers, you're going to get feudalism and dreck. I'd hop :)
"give it to god"-- god of course being the transformer.
April 18, 2025 at 5:25 PM
"give it to god"-- god of course being the transformer.
William Gibson owes it to the world to do another neuromancer, but where it's just descriptions of how lame the real person or prompt is behind every high follower X shitpost account. Instead of the real sexual content, dms with e-girls. Coin swindles making 5k instead of heists
April 18, 2025 at 3:16 PM
William Gibson owes it to the world to do another neuromancer, but where it's just descriptions of how lame the real person or prompt is behind every high follower X shitpost account. Instead of the real sexual content, dms with e-girls. Coin swindles making 5k instead of heists
If universities don't stand up to the "dark enlightenment" they will lose all their relevance.
Breaking News: Harvard rejected the Trump administration’s demands, including that it submit to monitoring and reduce the power of faculty and students.
Harvard Will Not Comply With a List of Trump Administration Demands
Federal officials said Harvard must enact “merit-based reform” in hiring and admissions, among other things. Harvard called the demands unlawful.
www.nytimes.com
April 14, 2025 at 6:36 PM
If universities don't stand up to the "dark enlightenment" they will lose all their relevance.