Johan Nakuci
johannakuci.bsky.social
Johan Nakuci
@johannakuci.bsky.social
Neuroscientist on the job market
Formerly at ARL, Georgia Tech, UB
How does variability in activity impact decision-making?

Using CNNs, we show that trial-level variability reflects decisions with: (i) strong sensory evidence, (ii) low discriminability and (iii) sensory evidence provides conflicting information.

www.biorxiv.org/content/10.1...
Brain-like variability in convolutional neural networks reveals evidence-,uncertainty- and bias-driven decision-making
Even when stimuli and tasks are held constant, brain activity fluctuates markedly across trials, yet it is not well understood how these fluctuations affect decision-making and behavior. Here we addre...
www.biorxiv.org
September 22, 2025 at 3:19 PM
The brain has many neurotransmitter and neuromodulators, but which ones are driving brain activity at any moment? Using PET derived neuroreceptor maps we show that BOLD signal is driven by two neuroreceptors modules.

www.nature.com/articles/s42...
The neuroreceptors and transporters underlying spontaneous brain activity - Communications Biology
PET-derived maps of 19 neuroreceptors accurately reconstruct BOLD signals, revealing two neuroreceptor modules orchestrating brain activity, recapitulate LSD and Modafinil binding profiles, and identi...
www.nature.com
July 30, 2025 at 5:17 PM
We introduce a remnant functional networks-based framework to compare how functional connectivity is shaped by physical and molecular factors -- structural connectivity, physical distance, genetic and neuroreceptor congruence.

direct.mit.edu/netn/article...
Quantifying the influence of biophysical factors in shaping brain communication through remnant functional networks
Abstract. Functional connectivity (FC) reflects brain-wide communication essential for cognition, yet the role of underlying biophysical factors in shaping FC remains unclear. We quantify the influenc...
direct.mit.edu
June 5, 2025 at 10:57 PM
Here we leverage trial-to-trial fluctuations in the brain-wide signal recorded using functional MRI to test if distinct sets of brain regions are activated on different trials when accomplishing the same task.
www.nature.com/articles/s41...
Multiple brain activation patterns for the same perceptual decision-making task - Nature Communications
Here, the authors show the brain uses multiple activation patterns to perform the same task. Even the default mode network, which is often inactive during focus, plays a role.
www.nature.com
February 20, 2025 at 4:26 AM