Spatial multi-omics analysis (with COMET) of brains revealed that cells in the TPPB/RT combination treatment group exhibited fewer and shorter TMs, reduced proliferation, increased cell death, and decreased TTYH1 expression (a driver of TM invasion)

#GBM #COMET #Lunaphore @bio-techne.bsky.social

How to disconnect therapy-resistant tumor networks in glioblastoma?

In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...

Inauguration du COMET Lunaphore au @crcordeliers.bsky.social financé par le @canceropole.bsky.social et les SiRICs @siriccarpem.bsky.social, In Situ, Curamus, Curie
@cancerparisnord.bsky.social
@institpariscarpem.bsky.social
@ap-hp.bsky.social
@inserm.fr
UP Cité
@sorbonne-universite.frm

🚀 Top départ de la journée d’inauguration du Lunaphore COMET sur notre plateforme CHICS
Les bancs sont remplis et une journée qui s'annonce passionnante!
Merci aux financeurs et tutelles
@canceropole.bsky.social @siriccarpem.bsky.social
@inserm.fr @sorbonne-universite.fr @upcite.bsky.social

I'm thrilled to travel to Brisbane this week to meet with multiomics enthusiasts - let's talk #spatial and see how Lunaphore can help accelerate your next discovery #multiomics2024