Jon Downie
@jmdownie.bsky.social
Senior GI fellow @MGH_GI. Graduate of @MGHMedicine and @UofUMedicine (MD/PhD). Studying GI diseases through the lens of ‘omics.
Excited to share our paper comparing two scRNA sequencing approaches to profile the colonic epithelium is now out as the inaugural “Technical Advance” article in @aga-cmgh.bsky.social! This new series highlights emerging methods in GI research. bit.ly/42vJ4qp #GI #science
Droplet vs Picowell: Considerations for Single-cell Transcriptomic Profiling of Human Colon Biopsies
Cellular and molecular profiling of gastrointestinal disease, especially cancer, has
primarily focused on transcriptional dysfunction within epithelial cells; however,
profiling epithelial cells from ...
bit.ly
April 11, 2025 at 2:57 PM
Excited to share our paper comparing two scRNA sequencing approaches to profile the colonic epithelium is now out as the inaugural “Technical Advance” article in @aga-cmgh.bsky.social! This new series highlights emerging methods in GI research. bit.ly/42vJ4qp #GI #science
Hello #medsky! I’m a senior GI fellow and physician scientist at MGH. I utilize ‘omics to understand risk and mechanisms of digestive diseases, namely colorectal cancer and GI bleeding. I recently published a study on circulating metabolites associated w/ CRC incidence! tinyurl.com/Downie-jnci 🧪
Novel metabolomic predictors of incident colorectal cancer in men and women
AbstractBackground. Metabolomic profiles may influence colorectal cancer (CRC) development. Few studies have performed pre-diagnostic metabolome-wide analy
tinyurl.com
November 15, 2024 at 7:12 PM
Hello #medsky! I’m a senior GI fellow and physician scientist at MGH. I utilize ‘omics to understand risk and mechanisms of digestive diseases, namely colorectal cancer and GI bleeding. I recently published a study on circulating metabolites associated w/ CRC incidence! tinyurl.com/Downie-jnci 🧪