John Maraganore
@jmaraganore.bsky.social
Founding CEO of Alnylam Pharmaceuticals. RNAi therapeutics pioneer.
CEO and Principal of JMM Innovations, LLC. Committed to advancing biomedical innovation to patients.
CEO and Principal of JMM Innovations, LLC. Committed to advancing biomedical innovation to patients.
I’m super excited to launch Corsera Health! This is another collaboration with my friend Clive Meanwell.
Our vision: a world without Cardiovascular disease!
www.businesswire.com/news/home/20...
Our vision: a world without Cardiovascular disease!
www.businesswire.com/news/home/20...
www.businesswire.com
September 2, 2025 at 10:49 AM
I’m super excited to launch Corsera Health! This is another collaboration with my friend Clive Meanwell.
Our vision: a world without Cardiovascular disease!
www.businesswire.com/news/home/20...
Our vision: a world without Cardiovascular disease!
www.businesswire.com/news/home/20...
www.washingtonpost.com/business/202...
Basic research “is almost like the starter when you bake sourdough bread. You can’t make the bread without it.”
Basic research “is almost like the starter when you bake sourdough bread. You can’t make the bread without it.”
Inside science labs trying to survive in the Trump era
Anastasia Khvorova’s lab at U-Mass. Chan Medical School shows how quickly the administration is dismantling an 80-year partnership that made the U.S. a scientific superpower.
www.washingtonpost.com
August 11, 2025 at 10:43 AM
www.washingtonpost.com/business/202...
Basic research “is almost like the starter when you bake sourdough bread. You can’t make the bread without it.”
Basic research “is almost like the starter when you bake sourdough bread. You can’t make the bread without it.”
“Brain drain” of scientists could have DIRE consequences for US leadership!
“Europe, Canada, and China are laying out the red carpet to attract scientists disillusioned by America’s shifting policies.”
🙏 Ashish Jha for this thoughtful piece!
www.bostonglobe.com/2025/05/27/o...
“Europe, Canada, and China are laying out the red carpet to attract scientists disillusioned by America’s shifting policies.”
🙏 Ashish Jha for this thoughtful piece!
www.bostonglobe.com/2025/05/27/o...
Trump policies threaten brain drain in biomedical research - The Boston Globe
Three-quarters of US-based researchers and graduate students are considering working abroad, according to a recent study.
www.bostonglobe.com
May 30, 2025 at 3:51 AM
“Brain drain” of scientists could have DIRE consequences for US leadership!
“Europe, Canada, and China are laying out the red carpet to attract scientists disillusioned by America’s shifting policies.”
🙏 Ashish Jha for this thoughtful piece!
www.bostonglobe.com/2025/05/27/o...
“Europe, Canada, and China are laying out the red carpet to attract scientists disillusioned by America’s shifting policies.”
🙏 Ashish Jha for this thoughtful piece!
www.bostonglobe.com/2025/05/27/o...
SO PROUD of the City Team forming their 2nd major alliance!!!!
This time with Biogen for a CNS target, w/ $46M upfront and >$1B in total deal value!
Combined with earlier Bausch & Lomb deal, City is growing strong in a tough tape!
www.globenewswire.com/news-release...
This time with Biogen for a CNS target, w/ $46M upfront and >$1B in total deal value!
Combined with earlier Bausch & Lomb deal, City is growing strong in a tough tape!
www.globenewswire.com/news-release...
Biogen and City Therapeutics Announce Strategic Research Collaboration to Develop Select Novel RNAi-based Therapies
Collaboration leverages City Therapeutics’ next-generation RNAi engineering technologies and Biogen’s extensive drug development expertise...
www.globenewswire.com
May 27, 2025 at 11:47 AM
SO PROUD of the City Team forming their 2nd major alliance!!!!
This time with Biogen for a CNS target, w/ $46M upfront and >$1B in total deal value!
Combined with earlier Bausch & Lomb deal, City is growing strong in a tough tape!
www.globenewswire.com/news-release...
This time with Biogen for a CNS target, w/ $46M upfront and >$1B in total deal value!
Combined with earlier Bausch & Lomb deal, City is growing strong in a tough tape!
www.globenewswire.com/news-release...
I’m all for real “MAHA!” Everyone should be!
Here are some real ideas from experts.
www.statnews.com/2025/05/21/r...
Here are some real ideas from experts.
www.statnews.com/2025/05/21/r...
Three big ideas to actually ‘Make America Healthy Again’
STAT reviewed dozens of studies, interviewed chronic disease experts, and landed on three focus areas for Robert F. Kennedy Jr. to boost health.
www.statnews.com
May 22, 2025 at 10:26 PM
I’m all for real “MAHA!” Everyone should be!
Here are some real ideas from experts.
www.statnews.com/2025/05/21/r...
Here are some real ideas from experts.
www.statnews.com/2025/05/21/r...
“The report also raises concerns about… children and their prescription drug use, including antibiotics and medications used to treat attention deficit disorders.
So, where’s the “gold-standard science” supporting these and other purported concerns?
www.bostonglobe.com/2025/05/22/n...
So, where’s the “gold-standard science” supporting these and other purported concerns?
www.bostonglobe.com/2025/05/22/n...
RFK Jr.’s MAHA report raises concerns about vaccines, American foods and prescription drugs - The Boston Globe
The report will be used over the next 100 days for the MAHA commission to fashion a plan that can be implemented during the remainder of President Trump’s term.
www.bostonglobe.com
May 22, 2025 at 5:10 PM
“The report also raises concerns about… children and their prescription drug use, including antibiotics and medications used to treat attention deficit disorders.
So, where’s the “gold-standard science” supporting these and other purported concerns?
www.bostonglobe.com/2025/05/22/n...
So, where’s the “gold-standard science” supporting these and other purported concerns?
www.bostonglobe.com/2025/05/22/n...
“Proposed funding cuts, the firing of essential federal scientists, and policy uncertainties threaten to undermine the foundation for our nation’s global leadership,” Collins said.
I could not agree more!
I could not agree more!
GOP Senator Collins says Trump’s layoffs of scientists, cuts to biomedical research ‘must be reversed’ www.statnews.com/2025/04/30/n... via John Wilkerson for @statnews.com
GOP Senator Collins says Trump’s layoffs of scientists, cuts to biomedical research ‘must be reversed’
Trump's canceled NIH grants and HHS layoffs threaten U.S. biomedical leadership, Collins says, as she calls for funding to be restored.
www.statnews.com
April 30, 2025 at 2:49 PM
“Proposed funding cuts, the firing of essential federal scientists, and policy uncertainties threaten to undermine the foundation for our nation’s global leadership,” Collins said.
I could not agree more!
I could not agree more!
IMO…
Bigger risks to KSQ are:
- Capital markets, made worse by uncertainty of destabilized FDA and tariffs
- Attack on academic institutions and science
- “Hybrid” work, with fewer people interacting in KSQ
www.bostonglobe.com/2025/04/14/b...
Bigger risks to KSQ are:
- Capital markets, made worse by uncertainty of destabilized FDA and tariffs
- Attack on academic institutions and science
- “Hybrid” work, with fewer people interacting in KSQ
www.bostonglobe.com/2025/04/14/b...
‘I think it is actively happening’: Is Boston’s biotech industry doomed? - The Boston Globe
With a "terrible" job market, empty labs, and mounting competition from China, the lifeblood of Kendall Square is under massive threat.
www.bostonglobe.com
April 15, 2025 at 12:16 PM
IMO…
Bigger risks to KSQ are:
- Capital markets, made worse by uncertainty of destabilized FDA and tariffs
- Attack on academic institutions and science
- “Hybrid” work, with fewer people interacting in KSQ
www.bostonglobe.com/2025/04/14/b...
Bigger risks to KSQ are:
- Capital markets, made worse by uncertainty of destabilized FDA and tariffs
- Attack on academic institutions and science
- “Hybrid” work, with fewer people interacting in KSQ
www.bostonglobe.com/2025/04/14/b...
We must preserve our U.S. leadership in science and medicine!
Also supported by economic grounds alone…. “History shows that science reliably generates immense economic benefit.”
www.cnn.com/2025/04/09/h...
Also supported by economic grounds alone…. “History shows that science reliably generates immense economic benefit.”
www.cnn.com/2025/04/09/h...
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
www.cnn.com
April 9, 2025 at 4:38 PM
We must preserve our U.S. leadership in science and medicine!
Also supported by economic grounds alone…. “History shows that science reliably generates immense economic benefit.”
www.cnn.com/2025/04/09/h...
Also supported by economic grounds alone…. “History shows that science reliably generates immense economic benefit.”
www.cnn.com/2025/04/09/h...
Some strategy tips for biotech CEOs in this brutal environment from a convo with @AndrewE_Dunn from @endpts.
My favorite tip (not covered as much in article) is to be hyper focused on what moves the needle for patients, and then investors.
endpts.com/biotech-mark...
My favorite tip (not covered as much in article) is to be hyper focused on what moves the needle for patients, and then investors.
endpts.com/biotech-mark...
Market turmoil is tanking biotech M&A and IPOs. Here's the playbook startups will use to survive
It’s a biotech environment without many good choices. Even before President Donald Trump’s tariff announcement pushed stock indices toward a bear market, biotech M&A has been virtually nonexistent, wi...
endpts.com
April 9, 2025 at 3:32 PM
Some strategy tips for biotech CEOs in this brutal environment from a convo with @AndrewE_Dunn from @endpts.
My favorite tip (not covered as much in article) is to be hyper focused on what moves the needle for patients, and then investors.
endpts.com/biotech-mark...
My favorite tip (not covered as much in article) is to be hyper focused on what moves the needle for patients, and then investors.
endpts.com/biotech-mark...
New company aiming to transform health… Exciting times ahead!
April 2, 2025 at 11:41 AM
New company aiming to transform health… Exciting times ahead!
Reposted by John Maraganore
It’s RFK Jr.’s FDA now
My take on Peter Marks' ouster -- and why you don't have to think Marks is a hero to be worried about what it means.
www.statnews.com/2025/03/31/r...
My take on Peter Marks' ouster -- and why you don't have to think Marks is a hero to be worried about what it means.
www.statnews.com/2025/03/31/r...
It’s RFK Jr.’s FDA now
Why the ouster of Peter Marks, a senior FDA official, is a huge deal, whether you liked him or not.
www.statnews.com
March 31, 2025 at 1:09 PM
It’s RFK Jr.’s FDA now
My take on Peter Marks' ouster -- and why you don't have to think Marks is a hero to be worried about what it means.
www.statnews.com/2025/03/31/r...
My take on Peter Marks' ouster -- and why you don't have to think Marks is a hero to be worried about what it means.
www.statnews.com/2025/03/31/r...
“I hope Marty comes understanding magnitude of his responsibility and builds back FDA that is based on science and being gold-standard regulatory authority of the world.”
www.statnews.com/2025/03/29/f...
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
Ouster of FDA’s Peter Marks alarms a biopharma industry that saw him as an ally
Will Peter Marks' ouster from the FDA change how pharma industry engages with the Trump administration?
www.statnews.com
March 30, 2025 at 1:53 PM
“I hope Marty comes understanding magnitude of his responsibility and builds back FDA that is based on science and being gold-standard regulatory authority of the world.”
www.statnews.com/2025/03/29/f...
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
Ouster of FDA’s Peter Marks alarms a biopharma industry that saw him as an ally
Will Peter Marks' ouster from the FDA change how pharma industry engages with the Trump administration?
www.statnews.com
March 30, 2025 at 1:53 PM
www.statnews.com/2025/03/29/f...
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.”
“never seen this large of a set of openings under one commissioner,”
www.wsj.com/politics/top...
“It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies”
“It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies”
Exclusive | Top Vaccine Official Out at FDA
In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.
www.wsj.com
March 29, 2025 at 1:34 AM
www.wsj.com/politics/top...
“It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies”
“It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies”
www.nature.com/articles/d41...
We must attract and RETAIN the greatest and best scientists in the world if the US is going to be “Great Again!”
We must attract and RETAIN the greatest and best scientists in the world if the US is going to be “Great Again!”
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
March 28, 2025 at 3:41 PM
www.nature.com/articles/d41...
We must attract and RETAIN the greatest and best scientists in the world if the US is going to be “Great Again!”
We must attract and RETAIN the greatest and best scientists in the world if the US is going to be “Great Again!”
Important oped by @DrSidMukherjee….
“we seem to be turning away from the idea that health is a collective endeavor, a public good at all, and retreating into the rhetoric of personal responsibility.”
Fully share this concern as our public health apparatus is being dismantled!
“we seem to be turning away from the idea that health is a collective endeavor, a public good at all, and retreating into the rhetoric of personal responsibility.”
Fully share this concern as our public health apparatus is being dismantled!
Opinion | Covid’s Deadliest Effect Took Five Years to Appear
What once belonged to all of us now belongs to corporations.
www.nytimes.com
March 17, 2025 at 12:49 PM
Important oped by @DrSidMukherjee….
“we seem to be turning away from the idea that health is a collective endeavor, a public good at all, and retreating into the rhetoric of personal responsibility.”
Fully share this concern as our public health apparatus is being dismantled!
“we seem to be turning away from the idea that health is a collective endeavor, a public good at all, and retreating into the rhetoric of personal responsibility.”
Fully share this concern as our public health apparatus is being dismantled!
We lead the world in science and medicine for patients!
A big part of this is our vibrant biotechnology industry…
But our leadership requires strong and well funded basic research at the @NIH!
A big part of this is our vibrant biotechnology industry…
But our leadership requires strong and well funded basic research at the @NIH!
At NIH, ‘everyone is on edge’ as they brace for deep cuts and more centralized control
www.statnews.com/2025/03/14/n...
www.statnews.com/2025/03/14/n...
At NIH, ‘everyone is on edge’ as they brace for deep cuts and more centralized control
As the NIH braces for cuts of up to 5,000 of its 20,000 positions, “people are scrambling and freaking out,” a researcher said.
www.statnews.com
March 15, 2025 at 3:35 AM
We lead the world in science and medicine for patients!
A big part of this is our vibrant biotechnology industry…
But our leadership requires strong and well funded basic research at the @NIH!
A big part of this is our vibrant biotechnology industry…
But our leadership requires strong and well funded basic research at the @NIH!
Completely avoidable.
March 7, 2025 at 1:25 AM
Completely avoidable.
Why. We. Do. What. We. Do!
Bravo @Regeneron!
Bravo @Regeneron!
Regeneron gene therapy improves hearing in 10 children with rare form of hearing loss
Regeneron’s investigational gene therapy has been tied to | Regeneron’s investigational gene therapy has been tied to notable hearing improvements in 10 of 11 children who were treated for a rare gene...
www.fiercebiotech.com
February 24, 2025 at 10:15 PM
Why. We. Do. What. We. Do!
Bravo @Regeneron!
Bravo @Regeneron!
Same story, 14 years and one day later.
For the sake of patients, let’s hope for the same outcome!
Keep going, CRISPR folk!
For the sake of patients, let’s hope for the same outcome!
Keep going, CRISPR folk!
February 6, 2025 at 10:32 AM
Same story, 14 years and one day later.
For the sake of patients, let’s hope for the same outcome!
Keep going, CRISPR folk!
For the sake of patients, let’s hope for the same outcome!
Keep going, CRISPR folk!
News like this makes my day…
- Great clinical data with profound impact for patients in high unmet need indication
- Market responds positively rewarding investors
A reminder that this is how biotech should work!
- Great clinical data with profound impact for patients in high unmet need indication
- Market responds positively rewarding investors
A reminder that this is how biotech should work!
Akero drug reverses liver scarring in study of severe MASH patients
Akero reported Monday strong results showing its drug efruxifermin reversed liver scarring in patients with cirrhosis caused by a disease known as MASH.
www.statnews.com
January 27, 2025 at 3:59 PM
News like this makes my day…
- Great clinical data with profound impact for patients in high unmet need indication
- Market responds positively rewarding investors
A reminder that this is how biotech should work!
- Great clinical data with profound impact for patients in high unmet need indication
- Market responds positively rewarding investors
A reminder that this is how biotech should work!
So fun to unite with ALumNY at JPM.
It’s so important to stay close with former colleagues in next chapters. Sometimes you end up working together again (as is the case with many here)!
It’s so important to stay close with former colleagues in next chapters. Sometimes you end up working together again (as is the case with many here)!
January 15, 2025 at 1:29 AM
So fun to unite with ALumNY at JPM.
It’s so important to stay close with former colleagues in next chapters. Sometimes you end up working together again (as is the case with many here)!
It’s so important to stay close with former colleagues in next chapters. Sometimes you end up working together again (as is the case with many here)!
This is great!
FDA modernization grounded in science and evidence would be welcome!
FDA modernization grounded in science and evidence would be welcome!
BIO gets a seat at the Trump admin's FDA reform table, even as RFK Jr. plays up his anti-industry ambitions endpts.com/bio-ceo-plan...
BIO CEO plans to join FDA modernization advisory board under Trump administration
John Crowley, CEO of the biotech advocacy group BIO, is slated to join a Trump administration advisory board focused on modernizing the FDA, according to a source familiar with the planning.
endpts.com
January 14, 2025 at 2:16 PM
This is great!
FDA modernization grounded in science and evidence would be welcome!
FDA modernization grounded in science and evidence would be welcome!