Jiacheng Miao
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jiachengmiao.bsky.social
Jiacheng Miao
@jiachengmiao.bsky.social
20 followers 43 following 1 posts
@Stanford Postdoc | AI Co-Scientists + Statistical Genetics
jiachengmiao.com
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Reposted by Jiacheng Miao
jeffspence.github.io
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪

www.nature.com/articles/d41...
How do genetic association studies rank genes?
Genome-wide association studies and rare-variant burden tests reveal complementary aspects of trait biology.
www.nature.com
November 19, 2025 at 6:43 PM
jiachengmiao.bsky.social
One of the coolest papers I’ve read. Changed the way I think about GWAS and burden testing.
jeffspence.github.io Jeff Spence @jeffspence.github.io · 14d
How do GWAS and rare variant burden tests rank gene signals?

In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!

🧬🧪🧵

www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:37 AM
Reposted by Jiacheng Miao
nathumbehav.nature.com
In this Article, Miao et al. introduce PIGEON, a statistical framework for estimating gene-environment interactions for complex traits.
PIGEON: a statistical framework for estimating gene–environment interaction for polygenic traits - Nature Human Behaviour
PIGEON is a statistical framework that uses summary statistics from genome-wide interaction studies to estimate how genes and environments jointly influence human complex traits.
www.nature.com
May 24, 2025 at 9:21 AM