Jan-Daniël de Leede
@jddeleede.bsky.social
PhD student in the Sonnen lab, Hubrecht Institute
Studying signalling dynamics in intestinal organoids
Studying signalling dynamics in intestinal organoids
New preprint from the lab! Gradients are... dynamic?! Spatially separated ligand-receptor pairs to tune signalling? Great work by @wilkemeijer.bsky.social @virginiar-andra.bsky.social Find out more⬇️
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
September 11, 2025 at 9:08 AM
New preprint from the lab! Gradients are... dynamic?! Spatially separated ligand-receptor pairs to tune signalling? Great work by @wilkemeijer.bsky.social @virginiar-andra.bsky.social Find out more⬇️
Reposted by Jan-Daniël de Leede
How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...
March 11, 2025 at 12:29 PM
How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...