Jay Yarbro
@jaymy.bsky.social
Postdoc @ St. Jude | Proteomics and multi-omic integration, primarily in Alzheimer's and other ADRD | PhD Genetics, Genomics & Informatics
Reposted by Jay Yarbro
🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
A study of gene expression in the living human brain - Molecular Psychiatry
Molecular Psychiatry - A study of gene expression in the living human brain
www.nature.com
August 28, 2025 at 1:21 PM
🤯 Postmortem vs Living brain
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain.
"Expression levels differed significantly for nearly 80% of genes,"🤯
www.nature.com/articles/s41...
Excited to share our new paper in Nature Structural & Molecular Biology! We show that midkine attenuates Aβ fibril assembly and plaque formation, highlighting a protective role in AD progression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Midkine attenuates amyloid-β fibril assembly and plaque formation - Nature Structural & Molecular Biology
Zaman, Yang and Huang et al. demonstrate MDK’s suppressive effect on amyloid-β and its impact on amyloid burden and microglial activation in Alzheimer disease mice, highlighting its protective role in...
www.nature.com
August 21, 2025 at 1:23 PM
Excited to share our new paper in Nature Structural & Molecular Biology! We show that midkine attenuates Aβ fibril assembly and plaque formation, highlighting a protective role in AD progression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to announce that our new review on Alzheimer’s proteomics is out in Molecular Neurodegeneration: doi.org/10.1186/s130... #Alzheimers #Proteomics #MassSpec
Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025) - Molecular Neurodegeneration
The advancements of proteomics technologies are shaping Alzheimer's disease (AD) research, revealing new molecular insights and improving biomarker discovery. Here, we summarize major AD proteomics st...
doi.org
July 14, 2025 at 1:50 PM
Happy to announce that our new review on Alzheimer’s proteomics is out in Molecular Neurodegeneration: doi.org/10.1186/s130... #Alzheimers #Proteomics #MassSpec
Excited to share our new paper! We mapped proteomic changes in AD mouse models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more: www.nature.com/articles/s41... #MassSpec #Proteinturnover #AlzheimersResearch #omics #proteomics
Human and mouse proteomics reveals the shared pathways in Alzheimer’s disease and delayed protein turnover in the amyloidome - Nature Communications
This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into ...
www.nature.com
February 12, 2025 at 8:30 PM
Excited to share our new paper! We mapped proteomic changes in AD mouse models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more: www.nature.com/articles/s41... #MassSpec #Proteinturnover #AlzheimersResearch #omics #proteomics