James Hemker
@jahemker.bsky.social
Stanford Dev Bio PhD
@petrovadmitri.bsky.social's lab
Carcharodontosaurus is my favorite dinosaur.
@petrovadmitri.bsky.social's lab
Carcharodontosaurus is my favorite dinosaur.
Reposted by James Hemker
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 11, 2025 at 5:15 PM
Super excited that the bulk of my PhD work is now preprinted! Here we used whole-community competition, or coalescence, experiments to quantify selection acting on genetically diverged strains within larger communities. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by James Hemker
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by James Hemker
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601
recruit.ap.uci.edu/JPF09601
Junior, Assistant, or Associate Specialist – Xue Lab
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
July 17, 2025 at 8:32 PM
The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601
recruit.ap.uci.edu/JPF09601
Grateful to be talking at #Evol2025! Will be presenting on how long Nanopore reads need to be in order to accurately call structural variants in Drosophila at the population level. Talk is at 3pm on Saturday in the Genomics III section. If you can’t make it get in touch!
June 20, 2025 at 10:32 PM
Grateful to be talking at #Evol2025! Will be presenting on how long Nanopore reads need to be in order to accurately call structural variants in Drosophila at the population level. Talk is at 3pm on Saturday in the Genomics III section. If you can’t make it get in touch!
Reposted by James Hemker
1/9 Excited to share the preprint for the second half of my PhD with @mollyschumer.bsky.social: Connecting human environmental impacts to hybridization in swordtail fish through genomics, GIS, water chemistry, and histology. Thread below!
#SciSky
www.biorxiv.org/content/10.1...
#SciSky
www.biorxiv.org/content/10.1...
Increased rates of hybridization in swordtail fish are associated with water pollution
Biodiversity loss can occur when disturbance compromises the reproductive barriers between species, causing them to collapse into a single population through hybridization. Recent research has documen...
www.biorxiv.org
May 1, 2025 at 1:15 PM
1/9 Excited to share the preprint for the second half of my PhD with @mollyschumer.bsky.social: Connecting human environmental impacts to hybridization in swordtail fish through genomics, GIS, water chemistry, and histology. Thread below!
#SciSky
www.biorxiv.org/content/10.1...
#SciSky
www.biorxiv.org/content/10.1...
Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...
Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin
The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the eff...
doi.org
April 25, 2025 at 8:03 PM
Excited to share the first manuscript from my PhD in which we leveraged ultra-long Nanopore sequencing, D. melanogaster inbred lines, and a ton of manual validation to investigate the effects of long-read length on population-level structural variant (SV) calling accuracy! doi.org/10.1101/2025...
Reposted by James Hemker
Thrilled to see this work, led by @lisacouper.bsky.social now out!
We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵
www.pnas.org/doi/10.1073/...
We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵
www.pnas.org/doi/10.1073/...
www.pnas.org
January 21, 2025 at 3:56 PM
Thrilled to see this work, led by @lisacouper.bsky.social now out!
We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵
www.pnas.org/doi/10.1073/...
We quantified variation in thermal tolerance in the mosquito, Aedes sierrensis, to quantify how adaptation may alter disease vector distributions under warming. 🧵
www.pnas.org/doi/10.1073/...