International Society of Genetic Genealogy
@isogg.bsky.social
Founded in 2005, the mission of the International Society of Genetic Genealogy is to advocate for and educate about the use of genetics as a tool for genealogical research. ISOGG is FREE! To join: isogg.org #ISOGG #DNA #epigenetics
“The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) that enables cells to maintain their proper balance of #NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels.” #ISOGG #DNA case.edu/news/new-stu...
New study shows Alzheimer’s disease can be reversed to achieve full neurological recovery—not just prevented or slowed—in animal models | CWRU Newsroom | Case Western Reserve University
For more than a century, people have considered Alzheimer's disease (AD) an irreversible illness. Consequently, research has focused on preventing or ...
case.edu
January 13, 2026 at 7:23 AM
“The pharmacological approach in this study, however, uses a pharmacologic agent (P7C3-A20) that enables cells to maintain their proper balance of #NAD+ under conditions of otherwise overwhelming stress, without elevating NAD+ to supraphysiologic levels.” #ISOGG #DNA case.edu/news/new-stu...
“By using state-of-the-art DNA techniques and newly published genomes, we were able to determine the ancestry of the Beachy Head Woman with much greater precision than before,” William reveals.” #ISOGG #DNA #AncientDNA #BeachyHeadWoman #UK www.nhm.ac.uk/discover/new...
The changing story of the Beachy Head Woman | Natural History Museum
The identity of a mysterious Roman-era skeleton found in southern England may have finally been resolved.
www.nhm.ac.uk
January 11, 2026 at 5:54 AM
“By using state-of-the-art DNA techniques and newly published genomes, we were able to determine the ancestry of the Beachy Head Woman with much greater precision than before,” William reveals.” #ISOGG #DNA #AncientDNA #BeachyHeadWoman #UK www.nhm.ac.uk/discover/new...
“If these efforts manage to pinpoint Leonardo’s Y chromosome, its sequence would become the project’s genomic ground truth” #DNA #ISOGG #LeonardodaVinci www.science.org/content/arti...
Exclusive: Have scientists found Leonardo da Vinci’s DNA?
Inside the decadeslong quest to reveal the genes of a genius—and revolutionize art authentication
www.science.org
January 8, 2026 at 9:12 PM
“If these efforts manage to pinpoint Leonardo’s Y chromosome, its sequence would become the project’s genomic ground truth” #DNA #ISOGG #LeonardodaVinci www.science.org/content/arti...
Reposted by International Society of Genetic Genealogy
IGG FREE KINDLE BOOK! #igg is the acronym for “Investigative Genetic Genealogy”. Use this link to get the book free on Kindle and if you don’t have a Kindle, you can read it using the Audible smartphone app.
genealogybargains.com/amazon-chest...
#FreeReads #Mystery #DNA #BookAddict #Kindle
genealogybargains.com/amazon-chest...
#FreeReads #Mystery #DNA #BookAddict #Kindle
Amazon.com
genealogybargains.com
December 28, 2025 at 2:35 PM
IGG FREE KINDLE BOOK! #igg is the acronym for “Investigative Genetic Genealogy”. Use this link to get the book free on Kindle and if you don’t have a Kindle, you can read it using the Audible smartphone app.
genealogybargains.com/amazon-chest...
#FreeReads #Mystery #DNA #BookAddict #Kindle
genealogybargains.com/amazon-chest...
#FreeReads #Mystery #DNA #BookAddict #Kindle
“Our data provide a foundational resource to decode human immune function and genetic variation and for new approaches to study gene regulatory networks.” #DNA #genetics
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits https://www.biorxiv.org/content/10.64898/2025.12.23.696273v1
December 24, 2025 at 5:42 PM
“Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD.” #ISOGG #DNA #epigenetics #cheese #brie #APOE4 #dementia www.neurology.org/doi/10.1212/...
High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia | Neurology
Background and ObjectivesThe association between dairy intake and dementia risk remains uncertain, especially
for dairy products with varying fat contents. The aim of this study was to investigate
the...
www.neurology.org
December 19, 2025 at 2:11 AM
“Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD.” #ISOGG #DNA #epigenetics #cheese #brie #APOE4 #dementia www.neurology.org/doi/10.1212/...
“We discovered 3 regions of the genome carrying distinct DNA methylation profiles in sperm from individuals with history of childhood psychological stress, notably at proximity of genes regulating the development of the central nervous system.” #ISOGG #DNA www.nature.com/articles/s41...
Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm - Molecular Psychiatry
Molecular Psychiatry - Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm
www.nature.com
December 10, 2025 at 3:54 AM
“We discovered 3 regions of the genome carrying distinct DNA methylation profiles in sperm from individuals with history of childhood psychological stress, notably at proximity of genes regulating the development of the central nervous system.” #ISOGG #DNA www.nature.com/articles/s41...
“Our finding high‐level & sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” pmc.ncbi.nlm.nih.gov/articles/PMC...
Mitochondrial DNA Pathogenic Variant Prevalence in Primary Mitochondrial Disease Patients With African (L) Mitochondrial Genome Haplogroups
Primary mitochondrial diseases (PMD) are caused by pathogenic variants in over 350 genes, 37 of which are located in mitochondrial DNA (mtDNA). While more than 100 mtDNA variants have confirmed disease associations, there are few reports of ...
pmc.ncbi.nlm.nih.gov
December 1, 2025 at 7:05 AM
“Our finding high‐level & sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” pmc.ncbi.nlm.nih.gov/articles/PMC...
Just finished watching the fascinating documentary “Secrets of the Neanderthals” on Netflix. Not a lot of DNA discussion but there is one part where they can identify whether the remains are male or female based on a dental protein. Here’s a link to the trailer: youtu.be/b5YtgLSU_sE?...
Secrets of the Neanderthals | Official Trailer | Netflix
YouTube video by Netflix
youtu.be
November 19, 2025 at 10:46 PM
“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," authors of the study conclude. #ISOGG #tirzepetide #epigenetics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide - Nature Medicine
This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.
www.nature.com
November 19, 2025 at 3:10 AM
“Our findings raise the possibility that this delta–theta band oscillation could serve as a target engagement biomarker, but its relationship to food preoccupation warrants more controlled investigation," authors of the study conclude. #ISOGG #tirzepetide #epigenetics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Magnesium treatment increases gut microbiome synthesizing vitamin D and inhibiting colorectal cancer: results from a double-blind precision-based randomized placebo-controlled trial
Carnobacterium maltaromaticum and Faecalibacterium prausnitzii induce de novo gut synthesis of vitamin D to inhibit colorectal carcinogenesis in mice.…
www.sciencedirect.com
November 16, 2025 at 5:08 PM
“In individuals with adequate TRPM7 function, Mg supplementation increases the abundance of C. maltaromaticum and F. prausnitzii.” #DNA #ISOGG #epigenetics #coloncancer #colorectalcancer #magnesium #TRPM7
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy
youtu.be/Tp96QZfzNlU?...
youtu.be/Tp96QZfzNlU?...
First reported death from meat allergy caused by tick bite
YouTube video by NBC News
youtu.be
November 14, 2025 at 10:17 PM
“Researchers have linked the death of a 47-year-old man in New Jersey to alpha-gal syndrome, which usually starts with a bite from a lone star tick. The man died four hours after eating a hamburger. NBC News’ Anne Thompson.” #ISOGG #epigenetics #AlphaGal #tick #allergy
youtu.be/Tp96QZfzNlU?...
youtu.be/Tp96QZfzNlU?...
“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...
Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation
Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and …
www.sciencedirect.com
November 11, 2025 at 3:48 PM
“Regarding the underlying mechanisms of action, it is tentatively believed that the primary intracellular target of hydrogen is the mitochondria. “…hydrogen can activate Nrf2 receptors, which can have beneficial effects on cardiovascular health and anti-aging." www.sciencedirect.com/science/arti...
“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Researchers issue warning after discovering unexpected link to heart failure: 'Appears to be increasing over time'
This is not the first research to highlight a connection.
www.yahoo.com
November 10, 2025 at 4:49 AM
“The study showed a statistical association with low and high temperature exposure and increased risk of all-cause and cardiovascular death in patients with heart failure.” #DNA #ISOGG #epigenetics
www.yahoo.com/news/article...
www.yahoo.com/news/article...
“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites
www.yahoo.com/news/article...
www.yahoo.com/news/article...
Scientists Found a Hidden Switch in Your Brain That Could Reverse Memory Loss
A new discovery shows that a protein called the ferritin light chain 1, or FTL1, plays a big role in the decline of our mental faculties as we age.
www.yahoo.com
November 9, 2025 at 1:33 AM
“The researchers hope that by targeting FTL1, future therapies may not only improve natural cognitive decline, but will also benefit people with neurodegenerative diseases.” #DNA #ISOGG #Alzheimers #epigentics #cognitivedecline #neutrites
www.yahoo.com/news/article...
www.yahoo.com/news/article...
“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...
www.mdpi.com
October 29, 2025 at 2:04 PM
“Many systemic challenges to the brain can be mitigated by the phytochemical sulforaphane (SF), which is important in supporting mitochondrial function. SF or its precursor glucoraphanin; broccoli seeds or sprouts, confers neuroprotective & cognitive benefits.” #ISOGG www.mdpi.com/2072-6643/17...
“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
Antidepressant Fluoxetine Promotes Brain Plasticity in Key Cells, Reshaping Their Energy Systems
A new study shows that the antidepressant fluoxetine does more than boost serotonin levels: it changes how brain cells manage their energy and rebuild their connections, potentially helping the brain ...
www.technologynetworks.com
October 27, 2025 at 7:32 PM
“Depression is linked to overly rigid brain circuits that resist change, and by softening these circuits and altering how their mitochondria function, fluoxetine may create a window of plasticity or flexibility in the brain. #DNA #ISOGG #Prozac #Epigenetics
www.technologynetworks.com/neuroscience...
www.technologynetworks.com/neuroscience...
“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...
news.yahoo.com/articles/dna...
DNA reveals what killed Napoleon's soldiers during their disastrous retreat from Russia in 1812
A mass grave holding soldiers from Napoleon Bonaparte's French army reveals some of the diseases that killed the Grande Armée during its disastrous retreat from Russia in 1812.
news.yahoo.com
October 26, 2025 at 5:45 AM
“The new study examined DNA from the teeth of 13 French soldiers buried during the retreat in a mass grave in Vilnius, Lithuania. (The grave was discovered during construction in 2001.)” #DNA #ISOGG #Napolean #French
news.yahoo.com/articles/dna...
news.yahoo.com/articles/dna...
“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...
Redirecting...
www.facebook.com
October 24, 2025 at 11:29 AM
“Until causative agents are identified and diagnostic tests developed, NCGS remains a diagnosis of exclusion, requiring careful systematic evaluation.” #DNA #ISOGG #epigenetics #gluten #FODMAPS www.unimelb.edu.au/newsroom/new...
“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...
Interbreeding with Neanderthals may be responsible for modern-day brain condition, SFU study finds
A new Simon Fraser University-led study reveals interbreeding between humans and their ancient cousins, Neanderthals, as the likely origin of a neurological condition estimated to impact up to one per...
www.sfu.ca
October 22, 2025 at 4:20 PM
“Their findings suggest that Chiari Malformation Type 1, a serious and sometimes fatal neurological condition, may be linked to Neanderthal genes that entered the human gene pool through interbreeding tens of thousands of years ago.” #DNA #ISOGG #AncientDNA #epigenetics www.sfu.ca/sfunews/medi...
“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...
Exclusive | My nonverbal autistic son began speaking at age 8 after taking wonder drug — he’d understood everything for years and had complaints
Nathaniel Schnier had notes — years’ worth of them.
nypost.com
October 15, 2025 at 12:28 PM
“The pediatric neurologist was studying whether leucovorin could help autistic children with cerebral folate deficiency — or a shortage of vitamin B9 in the brain.” #DNA #ISOGG #epigenetics #autism #folate #B9 nypost.com/2025/10/14/h...
"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group."
www.sciencealert.com/restless-leg...
www.sciencealert.com/restless-leg...
Restless Legs Treatment Slashes Increased Risk of Parkinson's Disease
A condition that compels people to move their legs could indicate they have a greater chance of developing Parkinson's disease.
www.sciencealert.com
October 14, 2025 at 12:58 AM
"Furthermore, patients with RLS who were not treated with dopamine agonists tended to be at increased risk of developing Parkinson's disease, whereas those who were treated with dopamine agonists tended to be at decreased risk compared with the control group."
www.sciencealert.com/restless-leg...
www.sciencealert.com/restless-leg...
Registration ends 30 Sept 2025 for the virtual East Coast Genetic Genealogy Conference. You have until 31 Dec 2025 to watch all of the recordings. There’s an ISOGG presentation where we celebrated ISOGG’s 20th year, review the history and discuss future goals. #ISOGG #DNA #ECGGC ecggc.org
2025 East Coast Genetic Genealogy Conference - ECGGC
East Coast Genetic Genealogy Conference
ecggc.org
September 29, 2025 at 6:42 PM
“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu
www.the-independent.com/news/science...
www.the-independent.com/news/science...
Century-old lungs stored in jar reveal how 1918 Spanish flu pandemic began
Findings could lead to better understanding of how viruses adapt to humans during a pandemic
www.the-independent.com
September 29, 2025 at 4:33 AM
“Another mutation of a protein in the virus’s membrane improved its ability to bind to entry point receptors in human cells, making it more resilient and infectious.” #isogg #DNA #epigentics #1918Flu #SpanishFlu
www.the-independent.com/news/science...
www.the-independent.com/news/science...
“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...
Cycling linked with lower dementia risk, study finds | CNN
Cycling instead of driving has been linked with a lower risk of dementia and Alzheimer’s disease, a large study has found.
www.cnn.com
September 24, 2025 at 11:39 PM
“Riding a bike is associated with a 19% lower risk of all-cause dementia and a 22% lower risk of Alzheimer’s disease, compared with taking nonactive travel modes such as a car, bus or train…” #ISOGG #DNA #epigenetics www.cnn.com/2025/09/20/h...