Takeshi Imai
@imailab.bsky.social
Neuroscientist. Studying neuronal circuit development, chemical senses, and light microscopy-based connectomics. Professor at Kyushu University.
Website: https://www.lab.med.kyushu-u.ac.jp/dn-en/
X: @TakeshiImaiLab
Website: https://www.lab.med.kyushu-u.ac.jp/dn-en/
X: @TakeshiImaiLab
Pinned
Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence
Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.
www.science.org
Our new paper is out in Science Advances! We found that dendritic compartment-specific spine “formation” during adolescence is critical for cortical development. We also found that schizophrenia-related genes are important in this process. (1/6)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Takeshi Imai
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Quantum spin resonance in engineered proteins for multimodal sensing - Nature
A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...
www.nature.com
January 21, 2026 at 4:19 PM
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Reposted by Takeshi Imai
#ELMI2026 will take place in Coimbra, Portugal 🇵🇹from June 16-19 hosted by @ppbioimaging.bsky.social colleagues. Submit your abstracts for oral presentations by January 18!
More information & registration🔽
ppbi.pt/wordpress/in...
More information & registration🔽
ppbi.pt/wordpress/in...
January 14, 2026 at 1:32 PM
#ELMI2026 will take place in Coimbra, Portugal 🇵🇹from June 16-19 hosted by @ppbioimaging.bsky.social colleagues. Submit your abstracts for oral presentations by January 18!
More information & registration🔽
ppbi.pt/wordpress/in...
More information & registration🔽
ppbi.pt/wordpress/in...
Our new paper is out in Science Advances! We found that dendritic compartment-specific spine “formation” during adolescence is critical for cortical development. We also found that schizophrenia-related genes are important in this process. (1/6)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence
Mouse models of schizophrenia show defects in adolescent spine formation in a specific dendritic compartment of L5 neurons.
www.science.org
January 15, 2026 at 1:42 AM
Our new paper is out in Science Advances! We found that dendritic compartment-specific spine “formation” during adolescence is critical for cortical development. We also found that schizophrenia-related genes are important in this process. (1/6)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Takeshi Imai
In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
May 23, 2025 at 2:47 PM
In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
Reposted by Takeshi Imai
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
www.science.org
April 17, 2025 at 11:46 PM
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Reposted by Takeshi Imai
✨New paper from my lab out now in @cp-cell.bsky.social!
We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
April 6, 2025 at 2:22 AM
✨New paper from my lab out now in @cp-cell.bsky.social!
We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
We identified pathways for airway protective reflexes—swallowing and coughing—in mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
Reposted by Takeshi Imai
If you are interested in what happens deep in the brain during puberty, please check our new paper in Neuron. We visualize how nutritional status shapes sexual maturation in female mice: A flagship study by an excellent postdoc Teppei Goto. (1/N
February 24, 2025 at 8:51 PM
If you are interested in what happens deep in the brain during puberty, please check our new paper in Neuron. We visualize how nutritional status shapes sexual maturation in female mice: A flagship study by an excellent postdoc Teppei Goto. (1/N
How does neural activity control developmental synapse elimination? Here is a new review paper from the lab: Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
January 27, 2025 at 12:13 PM
How does neural activity control developmental synapse elimination? Here is a new review paper from the lab: Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
Reposted by Takeshi Imai
A background in physics, and his own curiosity, have helped Dmitry Rinberg tackle the complexities of the neuroscience of smell. More on Rinberg sniffing out the mysteries of olfaction.
By Lina Zeldovich
www.thetransmitter.org/olfaction/sn...
By Lina Zeldovich
www.thetransmitter.org/olfaction/sn...
December 11, 2024 at 2:13 PM
A background in physics, and his own curiosity, have helped Dmitry Rinberg tackle the complexities of the neuroscience of smell. More on Rinberg sniffing out the mysteries of olfaction.
By Lina Zeldovich
www.thetransmitter.org/olfaction/sn...
By Lina Zeldovich
www.thetransmitter.org/olfaction/sn...
Reposted by Takeshi Imai
The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice - Nature Communications
How individual organs are specifically regulated by the sympathetic neurons at the cellular level remains not fully understood. Here, authors identify two molecularly distinct sympathetic pathways tha...
www.nature.com
December 10, 2024 at 10:55 AM
The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
From our recent paper: 7-color Tetbow image of the neocortex🌈 We can distinguish hundreds of neurons based on the combinatorial expression of 7 FPs.
Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...
Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...
December 11, 2024 at 1:46 AM
From our recent paper: 7-color Tetbow image of the neocortex🌈 We can distinguish hundreds of neurons based on the combinatorial expression of 7 FPs.
Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...
Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...
Hello, this is my first Bluesky post! We love neuroimaging🔬 Attached are covers from our lab featuring our favorite neurons, mitral cells in the olfactory bulb and L5 neurons in the neocortex. What's your #FavoriteNeuron?
December 11, 2024 at 1:20 AM
Hello, this is my first Bluesky post! We love neuroimaging🔬 Attached are covers from our lab featuring our favorite neurons, mitral cells in the olfactory bulb and L5 neurons in the neocortex. What's your #FavoriteNeuron?