Intensive Care Medicine Experimental (ICMx)
@icmexperimental.bsky.social
An @esicm.bsky.social open access journal dedicated to translational research.
🔗 https://link.springer.com/journal/40635
✍️ Authors http://bit.ly/AuthorsICMx
📲 Submit http://bit.ly/SubmitToICMx
🔗 https://link.springer.com/journal/40635
✍️ Authors http://bit.ly/AuthorsICMx
📲 Submit http://bit.ly/SubmitToICMx
⭐ ICMx 2025 Recap #VisualAbstract
Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future
doi.org/10.1186/s40635-025-00740-0
Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future
doi.org/10.1186/s40635-025-00740-0
January 3, 2026 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future
doi.org/10.1186/s40635-025-00740-0
Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future
doi.org/10.1186/s40635-025-00740-0
⭐ ICMx 2025 Recap #VisualAbstract
Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test
doi.org/10.1186/s40635-025-00735-x
Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test
doi.org/10.1186/s40635-025-00735-x
January 2, 2026 at 3:46 PM
⭐ ICMx 2025 Recap #VisualAbstract
Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test
doi.org/10.1186/s40635-025-00735-x
Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test
doi.org/10.1186/s40635-025-00735-x
⭐ ICMx 2025 Recap #VisualAbstract
Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome
doi.org/10.1186/s40635-025-00737-9
Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome
doi.org/10.1186/s40635-025-00737-9
January 2, 2026 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome
doi.org/10.1186/s40635-025-00737-9
Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome
doi.org/10.1186/s40635-025-00737-9
Happy New Year from ICMx! 🥂
Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you.
👉 Join our growing community on Bluesky: @icmexperimental.bsky.social
Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you.
👉 Join our growing community on Bluesky: @icmexperimental.bsky.social
January 1, 2026 at 10:51 AM
Happy New Year from ICMx! 🥂
Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you.
👉 Join our growing community on Bluesky: @icmexperimental.bsky.social
Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you.
👉 Join our growing community on Bluesky: @icmexperimental.bsky.social
⭐ ICMx 2025 Recap #VisualAbstract
Wearable devices for patient monitoring in the intensive care unit
doi.org/10.1186/s40635-025-00738-8
Wearable devices for patient monitoring in the intensive care unit
doi.org/10.1186/s40635-025-00738-8
December 31, 2025 at 3:46 PM
⭐ ICMx 2025 Recap #VisualAbstract
Wearable devices for patient monitoring in the intensive care unit
doi.org/10.1186/s40635-025-00738-8
Wearable devices for patient monitoring in the intensive care unit
doi.org/10.1186/s40635-025-00738-8
⭐ ICMx 2025 Recap #VisualAbstract
Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring
doi.org/10.1186/s40635-025-00733-z
Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring
doi.org/10.1186/s40635-025-00733-z
December 31, 2025 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring
doi.org/10.1186/s40635-025-00733-z
Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring
doi.org/10.1186/s40635-025-00733-z
⭐ ICMx 2025 Recap #VisualAbstract
Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study
doi.org/10.1186/s40635-025-00726-y
Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study
doi.org/10.1186/s40635-025-00726-y
December 30, 2025 at 3:46 PM
⭐ ICMx 2025 Recap #VisualAbstract
Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study
doi.org/10.1186/s40635-025-00726-y
Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study
doi.org/10.1186/s40635-025-00726-y
⭐ ICMx 2025 Recap #VisualAbstract
Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model
doi.org/10.1186/s40635-025-00732-0
Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model
doi.org/10.1186/s40635-025-00732-0
December 30, 2025 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model
doi.org/10.1186/s40635-025-00732-0
Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model
doi.org/10.1186/s40635-025-00732-0
⭐ ICMx 2025 Recap #VisualAbstract
Using weak signals to predict spontaneous breathing trial success: a machine learning approach
doi.org/10.1186/s40635-025-00724-0
Using weak signals to predict spontaneous breathing trial success: a machine learning approach
doi.org/10.1186/s40635-025-00724-0
December 29, 2025 at 3:46 PM
⭐ ICMx 2025 Recap #VisualAbstract
Using weak signals to predict spontaneous breathing trial success: a machine learning approach
doi.org/10.1186/s40635-025-00724-0
Using weak signals to predict spontaneous breathing trial success: a machine learning approach
doi.org/10.1186/s40635-025-00724-0
⭐ ICMx 2025 Recap #VisualAbstract
Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study
doi.org/10.1186/s40635-025-00722-2
Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study
doi.org/10.1186/s40635-025-00722-2
December 29, 2025 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study
doi.org/10.1186/s40635-025-00722-2
Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study
doi.org/10.1186/s40635-025-00722-2
⭐ ICMx 2025 Recap #VisualAbstract
From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss.
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
🔗 doi.org/10.1186/s40635-025-00717-z
From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss.
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
🔗 doi.org/10.1186/s40635-025-00717-z
December 22, 2025 at 3:46 PM
⭐ ICMx 2025 Recap #VisualAbstract
From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss.
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
🔗 doi.org/10.1186/s40635-025-00717-z
From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss.
Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices
🔗 doi.org/10.1186/s40635-025-00717-z
⭐ ICMx 2025 Recap #VisualAbstract
Kicking off our ICMx 2025 Year-in-Review!
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
🔗 doi.org/10.1186/s40635-024-00710-y
Kicking off our ICMx 2025 Year-in-Review!
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
🔗 doi.org/10.1186/s40635-024-00710-y
December 22, 2025 at 10:51 AM
⭐ ICMx 2025 Recap #VisualAbstract
Kicking off our ICMx 2025 Year-in-Review!
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
🔗 doi.org/10.1186/s40635-024-00710-y
Kicking off our ICMx 2025 Year-in-Review!
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review
🔗 doi.org/10.1186/s40635-024-00710-y
Unravelling the complex inflammatory landscape of COVID-19 infection
Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets.
🔗 doi.org/10.1186/s40635-025-00825-w
#MedSky #FOAMed #ICU #Covid19 #ImmunoSky
Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets.
🔗 doi.org/10.1186/s40635-025-00825-w
#MedSky #FOAMed #ICU #Covid19 #ImmunoSky
December 19, 2025 at 3:46 PM
Unravelling the complex inflammatory landscape of COVID-19 infection
Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets.
🔗 doi.org/10.1186/s40635-025-00825-w
#MedSky #FOAMed #ICU #Covid19 #ImmunoSky
Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets.
🔗 doi.org/10.1186/s40635-025-00825-w
#MedSky #FOAMed #ICU #Covid19 #ImmunoSky
Mitochondrial oxygen tension drops in acute sepsis and correlates with severity, yet recovers by follow-up, supporting reversible metabolic dysfunction rather than persistent failure.
🔗 doi.org/10.1186/s40635-025-00808-x
#MedSky #FOAMed #ICU #Sepsis #ImmunoSky
🔗 doi.org/10.1186/s40635-025-00808-x
#MedSky #FOAMed #ICU #Sepsis #ImmunoSky
December 18, 2025 at 4:15 PM
Mitochondrial oxygen tension drops in acute sepsis and correlates with severity, yet recovers by follow-up, supporting reversible metabolic dysfunction rather than persistent failure.
🔗 doi.org/10.1186/s40635-025-00808-x
#MedSky #FOAMed #ICU #Sepsis #ImmunoSky
🔗 doi.org/10.1186/s40635-025-00808-x
#MedSky #FOAMed #ICU #Sepsis #ImmunoSky
Hepatic and intestinal microcirculation and pulmonary inflammation in VV ECMO in rats
Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV.
🔗 doi.org/10.1186/s40635-025-00824-x
Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV.
🔗 doi.org/10.1186/s40635-025-00824-x
December 17, 2025 at 2:45 PM
Hepatic and intestinal microcirculation and pulmonary inflammation in VV ECMO in rats
Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV.
🔗 doi.org/10.1186/s40635-025-00824-x
Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV.
🔗 doi.org/10.1186/s40635-025-00824-x
Low-bicarbonate substitution and CO₂ removal in combined ECCO₂R-CRRT
A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target.
👉 doi.org/10.1186/s40635-025-00827-8
#MedSky#ICU #ARDS
A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target.
👉 doi.org/10.1186/s40635-025-00827-8
#MedSky#ICU #ARDS
December 16, 2025 at 3:46 PM
Low-bicarbonate substitution and CO₂ removal in combined ECCO₂R-CRRT
A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target.
👉 doi.org/10.1186/s40635-025-00827-8
#MedSky#ICU #ARDS
A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target.
👉 doi.org/10.1186/s40635-025-00827-8
#MedSky#ICU #ARDS
Recovering mice restored NKA with more activating NKRs and cytotoxic subsets, while lethal sepsis showed persistent NK suppression.
🔗 doi.org/10.1186/s40635-025-00829-6
#MedSky #FOAMed #ImmunoSky #Sepsis #ICU
🔗 doi.org/10.1186/s40635-025-00829-6
#MedSky #FOAMed #ImmunoSky #Sepsis #ICU
December 15, 2025 at 3:46 PM
Recovering mice restored NKA with more activating NKRs and cytotoxic subsets, while lethal sepsis showed persistent NK suppression.
🔗 doi.org/10.1186/s40635-025-00829-6
#MedSky #FOAMed #ImmunoSky #Sepsis #ICU
🔗 doi.org/10.1186/s40635-025-00829-6
#MedSky #FOAMed #ImmunoSky #Sepsis #ICU
🩸 Knowledge gaps in extracorporeal blood purification
From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential.
🔗 doi.org/10.1186/s40635-025-00819-8
#MedSky #ICU #Sepsis
From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential.
🔗 doi.org/10.1186/s40635-025-00819-8
#MedSky #ICU #Sepsis
December 12, 2025 at 12:05 PM
🩸 Knowledge gaps in extracorporeal blood purification
From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential.
🔗 doi.org/10.1186/s40635-025-00819-8
#MedSky #ICU #Sepsis
From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential.
🔗 doi.org/10.1186/s40635-025-00819-8
#MedSky #ICU #Sepsis
REVIEW 🌊 Venous congestion from a vascular waterfall perspective
Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment.
🔗 doi.org/10.1186/s40635-025-00828-7
Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment.
🔗 doi.org/10.1186/s40635-025-00828-7
December 11, 2025 at 10:51 AM
REVIEW 🌊 Venous congestion from a vascular waterfall perspective
Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment.
🔗 doi.org/10.1186/s40635-025-00828-7
Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment.
🔗 doi.org/10.1186/s40635-025-00828-7
Fluid removal improves muscle performance and weakness in critically ill patients
Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z
Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z
December 10, 2025 at 10:15 AM
Fluid removal improves muscle performance and weakness in critically ill patients
Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z
Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z
Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR study
Early strategies boosting neutralization may be key.
🔗 doi.org/10.1186/s40635-025-00831-y
#MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky
Early strategies boosting neutralization may be key.
🔗 doi.org/10.1186/s40635-025-00831-y
#MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky
December 9, 2025 at 11:15 AM
Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR study
Early strategies boosting neutralization may be key.
🔗 doi.org/10.1186/s40635-025-00831-y
#MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky
Early strategies boosting neutralization may be key.
🔗 doi.org/10.1186/s40635-025-00831-y
#MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky
💪 MUScleNut study
Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies.
📎 doi.org/10.1186/s40635-025-00823-y
#MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS
Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies.
📎 doi.org/10.1186/s40635-025-00823-y
#MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS
December 8, 2025 at 10:51 AM
💪 MUScleNut study
Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies.
📎 doi.org/10.1186/s40635-025-00823-y
#MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS
Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies.
📎 doi.org/10.1186/s40635-025-00823-y
#MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS
How much #lung water is too much?🌊
This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring.
🔗 doi.org/10.1186/s40635-025-00752-w
#MedSky
This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring.
🔗 doi.org/10.1186/s40635-025-00752-w
#MedSky
May 23, 2025 at 10:31 AM
How much #lung water is too much?🌊
This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring.
🔗 doi.org/10.1186/s40635-025-00752-w
#MedSky
This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring.
🔗 doi.org/10.1186/s40635-025-00752-w
#MedSky
Can steroids reshape post-arrest metabolism?
High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential?
🔗 doi.org/10.1186/s40635-025-00754-8
#MedSky #CardioSky
High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential?
🔗 doi.org/10.1186/s40635-025-00754-8
#MedSky #CardioSky
May 22, 2025 at 8:40 AM
Can steroids reshape post-arrest metabolism?
High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential?
🔗 doi.org/10.1186/s40635-025-00754-8
#MedSky #CardioSky
High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential?
🔗 doi.org/10.1186/s40635-025-00754-8
#MedSky #CardioSky
In a new ICU mouse model, age and sex drive divergent responses to LPS-induced lung injury. Old males benefit most from ventilation, but old females fare worst. A step forward for translational critical care research.
🔗 doi.org/10.1186/s40635-025-00756-6
#MedSky #PulmSky #PulmCrit #IDSky
🔗 doi.org/10.1186/s40635-025-00756-6
#MedSky #PulmSky #PulmCrit #IDSky
May 21, 2025 at 3:05 PM
In a new ICU mouse model, age and sex drive divergent responses to LPS-induced lung injury. Old males benefit most from ventilation, but old females fare worst. A step forward for translational critical care research.
🔗 doi.org/10.1186/s40635-025-00756-6
#MedSky #PulmSky #PulmCrit #IDSky
🔗 doi.org/10.1186/s40635-025-00756-6
#MedSky #PulmSky #PulmCrit #IDSky