Henrik Salje
@hsalje.bsky.social
Infectious Disease Epidemiologist at University of Cambridge
Reposted by Henrik Salje
📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬
Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨
Key findings in thread below 👇
www.biorxiv.org/content/10.1...
Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨
Key findings in thread below 👇
www.biorxiv.org/content/10.1...
Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia
The release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...
www.biorxiv.org
September 19, 2025 at 7:23 PM
📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬
Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨
Key findings in thread below 👇
www.biorxiv.org/content/10.1...
Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨
Key findings in thread below 👇
www.biorxiv.org/content/10.1...
Reposted by Henrik Salje
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com
August 8, 2025 at 9:09 AM
🧵 Our paper out today in @naturemedicine.bsky.social
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
www.nature.com/articles/s41...
On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon
1/
#Immunosky #IDsky #MicroSky #globalhealth.
Reposted by Henrik Salje
🚨 Nipah virus poses a future #pandemic risk. New cases in Kerala, India further highlight the need for a One Health approach. Read more in our recent interdisciplinary and multi-institutional collaborative article now published in @NatureMicrobiology #LZCI : www.nature.com/articles/s41...
A One Health approach to understanding and managing Nipah virus outbreaks - Nature Microbiology
In this Perspective, Yadav et al. discuss NiV outbreaks, transmission cycles and the role of reservoir and bridging hosts. They also discuss a One Health approach to mitigate the risks of NiV epidemic...
www.nature.com
May 28, 2025 at 11:47 AM
🚨 Nipah virus poses a future #pandemic risk. New cases in Kerala, India further highlight the need for a One Health approach. Read more in our recent interdisciplinary and multi-institutional collaborative article now published in @NatureMicrobiology #LZCI : www.nature.com/articles/s41...
Reposted by Henrik Salje
Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies
Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...
journals.plos.org
February 11, 2025 at 4:21 PM
Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
journals.plos.org/ploscompbiol...
journals.plos.org/ploscompbiol...
Reposted by Henrik Salje
Phylowave; The latest framework developed by researchers to identify more infectious variants of viruses or bacteria, including those responsible for flu, #COVID and whooping cough.
"A vaccine can be specifically targeted against these variants, to make it as effective as possible"
🔗 rdcu.be/d5pFu
"A vaccine can be specifically targeted against these variants, to make it as effective as possible"
🔗 rdcu.be/d5pFu
January 3, 2025 at 3:53 PM
Phylowave; The latest framework developed by researchers to identify more infectious variants of viruses or bacteria, including those responsible for flu, #COVID and whooping cough.
"A vaccine can be specifically targeted against these variants, to make it as effective as possible"
🔗 rdcu.be/d5pFu
"A vaccine can be specifically targeted against these variants, to make it as effective as possible"
🔗 rdcu.be/d5pFu
Reposted by Henrik Salje
Great way to start the year! A paper in @nature.com by our amazing @noemie presenting a way to use sequences to identify pathogen lineages, quantify their fitness, and identify potentially important genes/snps . Works across bugs, even with minimally and biased set of sequences.
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
https://buff.ly/4gyYCzx
We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies.
🧵 A thread... 1/n
#IDSky #IDModelling
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
buff.ly
January 2, 2025 at 9:48 AM
Great way to start the year! A paper in @nature.com by our amazing @noemie presenting a way to use sequences to identify pathogen lineages, quantify their fitness, and identify potentially important genes/snps . Works across bugs, even with minimally and biased set of sequences.
Reposted by Henrik Salje
Great way to finish the year! Paper by our @huangat.bsky.social in @pnas.org showing that relying on seroconversions in cohorts will usually lead to horribly biased #dengue incidence estimates whereas models relying on age data from local hospital typically robust.
No one best way to measure #infection risk in populations.
Cross-sectional sero: weak temporal signal, CXR, waning as we know. Extra care needed for longitudinal #serology as Ab kinetics and assay noise can mess up estimates by a lot. Cases can be powerful!
www.pnas.org/doi/10.1073/pnas.2411768121
Cross-sectional sero: weak temporal signal, CXR, waning as we know. Extra care needed for longitudinal #serology as Ab kinetics and assay noise can mess up estimates by a lot. Cases can be powerful!
www.pnas.org/doi/10.1073/pnas.2411768121
Reconciling heterogeneous dengue virus infection risk estimates from different study designs | PNAS
Uncovering rates at which susceptible individuals become infected with a pathogen,
i.e., the force of infection (FOI), is essential for assessing t...
eur03.safelinks.protection.outlook.com
January 1, 2025 at 9:11 AM
Great way to finish the year! Paper by our @huangat.bsky.social in @pnas.org showing that relying on seroconversions in cohorts will usually lead to horribly biased #dengue incidence estimates whereas models relying on age data from local hospital typically robust.
Really excited by the creation of this new Unit with @ksbakes.bsky.social and @virologyhouldcroft.bsky.social working on the emergence, spread and control of infectious diseases at the University of Cambridge
Hello world! After a year in the making, the Pathogen Dynamics Unit is ready to launch! Check out our website (pdu.gen.cam.ac.uk) and follow the team (bsky.app/profile/did:...) to keep up with the latest from our infectious disease supergroup based at @geneticscam.bsky.social
December 20, 2024 at 2:51 PM
Really excited by the creation of this new Unit with @ksbakes.bsky.social and @virologyhouldcroft.bsky.social working on the emergence, spread and control of infectious diseases at the University of Cambridge
Reposted by Henrik Salje
Huge thanks to my supervisors Katie Hampson and Christina Cobbold, examiners @davidlrobertson.bsky.social and @hsalje.bsky.social and convener Louise Matthews!! And everyone else at UofG and beyond who have made the last 3.5 years an amazing time 😁🎉
A big congratulations to Dr. Rowan Durrant
(@rowandurrant.bsky.social) for successfully completing her viva yesterday!
📄Thesis: "Genetic analysis of the rabies virus" 🧬🦠
(@rowandurrant.bsky.social) for successfully completing her viva yesterday!
📄Thesis: "Genetic analysis of the rabies virus" 🧬🦠
December 12, 2024 at 10:18 AM
Huge thanks to my supervisors Katie Hampson and Christina Cobbold, examiners @davidlrobertson.bsky.social and @hsalje.bsky.social and convener Louise Matthews!! And everyone else at UofG and beyond who have made the last 3.5 years an amazing time 😁🎉
Reposted by Henrik Salje
We are very proud to share that @hsalje.bsky.social has been awarded an #ERC Consolidator Grant 🎉
He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠
He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠
December 4, 2024 at 4:51 PM
We are very proud to share that @hsalje.bsky.social has been awarded an #ERC Consolidator Grant 🎉
He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠
He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠
Could not be more deserved. Congratulations again Noémie.
Thrilled to have received this award, thank you @gensocuk.bsky.social! Many thanks to @hsalje.bsky.social @julianparkhill.bsky.social, Sylvain Brisse and the amazing research groups without whom the work wouldn't have been possible!
A big congratulations to Noémie Lefrancq on being awarded the Sir Kenneth Mather Memorial Prize🏅 for their exceptional PhD thesis on global dynamics of the bacterium behind whooping cough, using genomes from throughout Europe and the world!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
November 22, 2024 at 2:57 PM
Could not be more deserved. Congratulations again Noémie.
#Measles antibody dynamics are highly predictive. Knowing only a future mum’s titre, we can predict how the infant will respond to vaccine much later. We also see vaccine failure linked to csection birth - maybe due to way microbiome develops. Important these infants get 2nd dose t.co/MqxTtuIHTH
Dynamics of measles immunity from birth and following vaccination - Nature Microbiology
Measles remains a major threat to human health despite widespread vaccination. While we know that maternal antibodies can impair vaccine-induced immunity, the relative contributions of pre-existing im...
t.co
May 14, 2024 at 5:41 PM
#Measles antibody dynamics are highly predictive. Knowing only a future mum’s titre, we can predict how the infant will respond to vaccine much later. We also see vaccine failure linked to csection birth - maybe due to way microbiome develops. Important these infants get 2nd dose t.co/MqxTtuIHTH
Reposted by Henrik Salje
New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China. @hsalje.bsky.social www.nature.com/articles/s41...
Dynamics of measles immunity from birth and following vaccination - Nature Microbiology
Serological data modelling informs on immune interference from maternal antibodies on measles vaccine responses in infants and children.
www.nature.com
May 14, 2024 at 7:46 AM
New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China. @hsalje.bsky.social www.nature.com/articles/s41...
Congratulations to our amazing DR. Megan O’Driscoll @meganodris.bsky.social on successfully passing her PhD viva! State of the art in infectious disease serology. Thank you to Michael White and Stephen Baker for being excellent examiners.
February 5, 2024 at 9:02 AM
Congratulations to our amazing DR. Megan O’Driscoll @meganodris.bsky.social on successfully passing her PhD viva! State of the art in infectious disease serology. Thank you to Michael White and Stephen Baker for being excellent examiners.
We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa. jobs.cam.ac.uk/job/44461/
December 19, 2023 at 6:44 PM
We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa. jobs.cam.ac.uk/job/44461/
Reposted by Henrik Salje
Excited to present our poster on the genetic diversity of Nipah virus later today at Epidemics9 - Come say hi at poster P2.167! 🦇🧪#EpiSky @hsalje.bsky.social
November 29, 2023 at 8:13 AM
Excited to present our poster on the genetic diversity of Nipah virus later today at Epidemics9 - Come say hi at poster P2.167! 🦇🧪#EpiSky @hsalje.bsky.social
Reposted by Henrik Salje
🧪Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t @thelonevirologist.bsky.social www.nature.com/articles/s41...
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting - Nature
Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multi...
www.nature.com
November 22, 2023 at 11:43 PM
🧪Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t @thelonevirologist.bsky.social www.nature.com/articles/s41...
Reposted by Henrik Salje
The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫
The evolution and international spread of extensively drug resistant Shigella sonnei - Nature Commun...
An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, t...
www.nature.com
November 24, 2023 at 8:37 AM
The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫