Leanne Holt
@holtlm90.bsky.social
Assistant Professor in the Center for Substance Abuse Research at LKSOM Temple University 👩🔬 | Astrocytes are awesome 🌠🧠 | Dogs are the best 🐶
Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/
December 18, 2025 at 12:44 PM
Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/
Reposted by Leanne Holt
Repair after CNS injury is not strictly local!
We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!
www.nature.com/articles/s41...
We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!
www.nature.com/articles/s41...
Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
www.nature.com
December 17, 2025 at 5:21 PM
Repair after CNS injury is not strictly local!
We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!
www.nature.com/articles/s41...
We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!
www.nature.com/articles/s41...
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
October 20, 2025 at 3:28 PM
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳
Astrocytic CREB regulates transcriptional, neuronal, and behavioral responses to cocaine https://www.biorxiv.org/content/10.1101/2025.06.04.657899v1
June 10, 2025 at 12:24 PM
Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳