Jakub Harnos lab
@harnoslab.bsky.social
Our lab in Czechia investigates cellular signaling during developmental and homeostasis processes using a Xenopus embryo 🐸 and tissue cells 🧫.
See more at👇
https://www.sci.muni.cz/ofiz/en/harnos-lab-2/
Alumni @CDRBSinai (🇺🇸), @uniwuerzburg (🇩🇪)
See more at👇
https://www.sci.muni.cz/ofiz/en/harnos-lab-2/
Alumni @CDRBSinai (🇺🇸), @uniwuerzburg (🇩🇪)
Pinned
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation - Communications Biology
We mapped PRICKLE1–3 interactomes and identified PRICKLE3 as a key WNT/PCP regulator that stabilizes VANGL via CK1ε–RNF43 control, revealing a PRICKLE3-specific mechanism shaping polarity across verte...
www.nature.com
🔥 New paper out!
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
When you urgently need the restroom but get lost in a Xenopus development poster instead… 🐸🧠
Thanks to my lab heroes Lorena & Douglas for representing the #DaysOfOpenDoors at Masaryk University
#frogpower #MUNI
Thanks to my lab heroes Lorena & Douglas for representing the #DaysOfOpenDoors at Masaryk University
#frogpower #MUNI
January 11, 2026 at 12:21 PM
When you urgently need the restroom but get lost in a Xenopus development poster instead… 🐸🧠
Thanks to my lab heroes Lorena & Douglas for representing the #DaysOfOpenDoors at Masaryk University
#frogpower #MUNI
Thanks to my lab heroes Lorena & Douglas for representing the #DaysOfOpenDoors at Masaryk University
#frogpower #MUNI
🧪🐸 PhD position open in the Harnos Lab (Masaryk University, Brno)!
We study cell migration, WNT/PCP signaling, mitochondria & energy in Xenopus.
Start: June 2026 (flexible)
Apply by Feb 28, 2026
📩 harnos@sci.muni.cz
#PhDposition #CellBiology #Mitochondria #Xenopus #WNT #PCP
We study cell migration, WNT/PCP signaling, mitochondria & energy in Xenopus.
Start: June 2026 (flexible)
Apply by Feb 28, 2026
📩 harnos@sci.muni.cz
#PhDposition #CellBiology #Mitochondria #Xenopus #WNT #PCP
January 7, 2026 at 12:34 PM
🧪🐸 PhD position open in the Harnos Lab (Masaryk University, Brno)!
We study cell migration, WNT/PCP signaling, mitochondria & energy in Xenopus.
Start: June 2026 (flexible)
Apply by Feb 28, 2026
📩 harnos@sci.muni.cz
#PhDposition #CellBiology #Mitochondria #Xenopus #WNT #PCP
We study cell migration, WNT/PCP signaling, mitochondria & energy in Xenopus.
Start: June 2026 (flexible)
Apply by Feb 28, 2026
📩 harnos@sci.muni.cz
#PhDposition #CellBiology #Mitochondria #Xenopus #WNT #PCP
Just published a #BehindThePaper blog post about our new paper on PRICKLE3 and WNT/PCP signalling! 🧬 Check out the story behind the science and what we learned along the way 👇
communities.springernature.com/posts/behind...
communities.springernature.com/posts/behind...
January 6, 2026 at 3:44 PM
Just published a #BehindThePaper blog post about our new paper on PRICKLE3 and WNT/PCP signalling! 🧬 Check out the story behind the science and what we learned along the way 👇
communities.springernature.com/posts/behind...
communities.springernature.com/posts/behind...
With @fabianlab.bsky.social — first author and last author in their natural habitats. #IKEA_Biology #SameOffice_SameChallenges #Pat&Mat
January 6, 2026 at 2:15 PM
With @fabianlab.bsky.social — first author and last author in their natural habitats. #IKEA_Biology #SameOffice_SameChallenges #Pat&Mat
🚀 Check out the newly improved Harnos Lab webpages!
Our research on cell polarity, development, and migration - now with a fresh look.
👉 ueb1.sci.muni.cz/ofiz/en/harn...
#CellPolarity #DevelopmentalBiology #Xenopus #WntSignaling
Our research on cell polarity, development, and migration - now with a fresh look.
👉 ueb1.sci.muni.cz/ofiz/en/harn...
#CellPolarity #DevelopmentalBiology #Xenopus #WntSignaling
Harnos Lab - Section of Animal Physiology and Immunology
——– What we work withWe study early Xenopus frog embryos: a powerful model for developmental biology. 🐸 Why frogsTheir embryos are large, develop outside the body, and are ideal for live imaging and e...
ueb1.sci.muni.cz
January 6, 2026 at 11:50 AM
🚀 Check out the newly improved Harnos Lab webpages!
Our research on cell polarity, development, and migration - now with a fresh look.
👉 ueb1.sci.muni.cz/ofiz/en/harn...
#CellPolarity #DevelopmentalBiology #Xenopus #WntSignaling
Our research on cell polarity, development, and migration - now with a fresh look.
👉 ueb1.sci.muni.cz/ofiz/en/harn...
#CellPolarity #DevelopmentalBiology #Xenopus #WntSignaling
🔥 New paper out!
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation - Communications Biology
We mapped PRICKLE1–3 interactomes and identified PRICKLE3 as a key WNT/PCP regulator that stabilizes VANGL via CK1ε–RNF43 control, revealing a PRICKLE3-specific mechanism shaping polarity across verte...
www.nature.com
December 29, 2025 at 5:20 AM
🔥 New paper out!
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
Milé @msmtcr,
když příště nebude sedět JEDNO číslo v Letter of Intent s hlavním projektem a celý projekt je kvůli tomu AUTOMATICKY vyřazen bez jakéhokoli upozornění, stačil by nám jeden krátký email k opravě.
Místo toho: žádné review, a měsíce či roky práce v pr... myslím pryč.
když příště nebude sedět JEDNO číslo v Letter of Intent s hlavním projektem a celý projekt je kvůli tomu AUTOMATICKY vyřazen bez jakéhokoli upozornění, stačil by nám jeden krátký email k opravě.
Místo toho: žádné review, a měsíce či roky práce v pr... myslím pryč.
December 18, 2025 at 1:35 PM
Milé @msmtcr,
když příště nebude sedět JEDNO číslo v Letter of Intent s hlavním projektem a celý projekt je kvůli tomu AUTOMATICKY vyřazen bez jakéhokoli upozornění, stačil by nám jeden krátký email k opravě.
Místo toho: žádné review, a měsíce či roky práce v pr... myslím pryč.
když příště nebude sedět JEDNO číslo v Letter of Intent s hlavním projektem a celý projekt je kvůli tomu AUTOMATICKY vyřazen bez jakéhokoli upozornění, stačil by nám jeden krátký email k opravě.
Místo toho: žádné review, a měsíce či roky práce v pr... myslím pryč.
Merry Christmas from the Harnoš Lab 🎄🐸
See you in an exciting 2026! ✨
See you in an exciting 2026! ✨
December 17, 2025 at 7:15 PM
Merry Christmas from the Harnoš Lab 🎄🐸
See you in an exciting 2026! ✨
See you in an exciting 2026! ✨
New paper out in Sci Rep 🎉
Xenopus + azoles + developmental biology 🐸
A great collaboration with Veterinary University Brno.
Read it here: pubmed.ncbi.nlm.nih.gov/41350377/
Xenopus + azoles + developmental biology 🐸
A great collaboration with Veterinary University Brno.
Read it here: pubmed.ncbi.nlm.nih.gov/41350377/
Developmental toxicity of fluconazole and 1,2,4-triazole in Xenopus laevis - PubMed
Fluconazole (FLU) is a widely used antifungal agent frequently detected in surface waters because of its extensive use in medicine, agriculture, and personal care products.Despite concerns about its persistence and developmental toxicity in aquatic species, its effects on amphibians remain poorly un …
pubmed.ncbi.nlm.nih.gov
December 16, 2025 at 5:11 PM
New paper out in Sci Rep 🎉
Xenopus + azoles + developmental biology 🐸
A great collaboration with Veterinary University Brno.
Read it here: pubmed.ncbi.nlm.nih.gov/41350377/
Xenopus + azoles + developmental biology 🐸
A great collaboration with Veterinary University Brno.
Read it here: pubmed.ncbi.nlm.nih.gov/41350377/
🔥 BIG NEWS! 🔥
Thrilled to share that I have been selected as one of the MUNI Junior Star 2026 awardees! ⭐️
Huge congratulations to all fellow awardees — and thank you, MUNI, for this incredible opportunity! 🙌
Let’s make science shine. 💫
#MUNIJuniorStar #Science #Research #ProudMoment
Thrilled to share that I have been selected as one of the MUNI Junior Star 2026 awardees! ⭐️
Huge congratulations to all fellow awardees — and thank you, MUNI, for this incredible opportunity! 🙌
Let’s make science shine. 💫
#MUNIJuniorStar #Science #Research #ProudMoment
December 11, 2025 at 11:28 AM
🔥 BIG NEWS! 🔥
Thrilled to share that I have been selected as one of the MUNI Junior Star 2026 awardees! ⭐️
Huge congratulations to all fellow awardees — and thank you, MUNI, for this incredible opportunity! 🙌
Let’s make science shine. 💫
#MUNIJuniorStar #Science #Research #ProudMoment
Thrilled to share that I have been selected as one of the MUNI Junior Star 2026 awardees! ⭐️
Huge congratulations to all fellow awardees — and thank you, MUNI, for this incredible opportunity! 🙌
Let’s make science shine. 💫
#MUNIJuniorStar #Science #Research #ProudMoment
Preparing for my big talk at the GAMU Annual Conference 2025!
Grateful for the opportunity to share our science and the achievements of the Harnoš Lab. Vamos! 🚀🐸
Grateful for the opportunity to share our science and the achievements of the Harnoš Lab. Vamos! 🚀🐸
December 8, 2025 at 7:26 AM
Preparing for my big talk at the GAMU Annual Conference 2025!
Grateful for the opportunity to share our science and the achievements of the Harnoš Lab. Vamos! 🚀🐸
Grateful for the opportunity to share our science and the achievements of the Harnoš Lab. Vamos! 🚀🐸
MAGA — Make AMPHIBIANS Great Again! 🐸
We just wrapped up the 2nd Czech Amphibian Friends meeting: great interactions, strong science, midnight swimming, and exciting collaborations ahead.
Big plans for 2026 — stay tuned!
Vladimir Krylov, we missed you!
Proud to help organize this event.
We just wrapped up the 2nd Czech Amphibian Friends meeting: great interactions, strong science, midnight swimming, and exciting collaborations ahead.
Big plans for 2026 — stay tuned!
Vladimir Krylov, we missed you!
Proud to help organize this event.
November 28, 2025 at 1:17 PM
MAGA — Make AMPHIBIANS Great Again! 🐸
We just wrapped up the 2nd Czech Amphibian Friends meeting: great interactions, strong science, midnight swimming, and exciting collaborations ahead.
Big plans for 2026 — stay tuned!
Vladimir Krylov, we missed you!
Proud to help organize this event.
We just wrapped up the 2nd Czech Amphibian Friends meeting: great interactions, strong science, midnight swimming, and exciting collaborations ahead.
Big plans for 2026 — stay tuned!
Vladimir Krylov, we missed you!
Proud to help organize this event.
Our PhD student Šárka is now giving a chalk-talk presentation on her Prickle and neurulation work in front of her fellow students — and she is doing great! Go, Šárka! 🐸💪
#MUNI #PhDretreat #Xenopus #frogpower
#MUNI #PhDretreat #Xenopus #frogpower
November 13, 2025 at 5:32 PM
Our PhD student Šárka is now giving a chalk-talk presentation on her Prickle and neurulation work in front of her fellow students — and she is doing great! Go, Šárka! 🐸💪
#MUNI #PhDretreat #Xenopus #frogpower
#MUNI #PhDretreat #Xenopus #frogpower
How do you make a group of scientists really busy?
Organize a scientific speed-dating session! Three minutes per pair — the clock is brutal.
Happy to host this one! 🔬⏱️😄
#PhDretreat #MUNI
Organize a scientific speed-dating session! Three minutes per pair — the clock is brutal.
Happy to host this one! 🔬⏱️😄
#PhDretreat #MUNI
November 13, 2025 at 5:15 PM
How do you make a group of scientists really busy?
Organize a scientific speed-dating session! Three minutes per pair — the clock is brutal.
Happy to host this one! 🔬⏱️😄
#PhDretreat #MUNI
Organize a scientific speed-dating session! Three minutes per pair — the clock is brutal.
Happy to host this one! 🔬⏱️😄
#PhDretreat #MUNI
Honored to give a talk about Xenopus at the prestigious IMG courses in Prague today! Excited to introduce this amazing frog model to new audiences. 🐸 #FrogPower
November 10, 2025 at 9:23 AM
Honored to give a talk about Xenopus at the prestigious IMG courses in Prague today! Excited to introduce this amazing frog model to new audiences. 🐸 #FrogPower
Reposted by Jakub Harnos lab
A proper hashtag#WoodstockBio2 welcome for @odedrechavi.bsky.social — complete with the YMCA song (yes, really 😄).
With @harnoslab.bsky.social we couldn’t resist celebrating a scientist who truly embodies fun and courage in science.
#science #FabianLAB, @paveltomancak.bsky.social 🙏
With @harnoslab.bsky.social we couldn’t resist celebrating a scientist who truly embodies fun and courage in science.
#science #FabianLAB, @paveltomancak.bsky.social 🙏
October 30, 2025 at 2:55 PM
A proper hashtag#WoodstockBio2 welcome for @odedrechavi.bsky.social — complete with the YMCA song (yes, really 😄).
With @harnoslab.bsky.social we couldn’t resist celebrating a scientist who truly embodies fun and courage in science.
#science #FabianLAB, @paveltomancak.bsky.social 🙏
With @harnoslab.bsky.social we couldn’t resist celebrating a scientist who truly embodies fun and courage in science.
#science #FabianLAB, @paveltomancak.bsky.social 🙏
It’s fantastic to meet Oded Rechavi at my home institution! 🔥 Great chat about his work on the Dead Sea Scrolls, where his team used DNA analysis to reveal that some fragments came from different animals and regions — rewriting what we thought we knew about the oldest Bible. 📜🧬
October 30, 2025 at 2:07 PM
It’s fantastic to meet Oded Rechavi at my home institution! 🔥 Great chat about his work on the Dead Sea Scrolls, where his team used DNA analysis to reveal that some fragments came from different animals and regions — rewriting what we thought we knew about the oldest Bible. 📜🧬
It’s my greatest pleasure to co-organize this event! 🚀
PIs from Brno: come join us and see what this supportive initiative is all about! 🙌
#BrnoScience #YoungPIs #Networking
PIs from Brno: come join us and see what this supportive initiative is all about! 🙌
#BrnoScience #YoungPIs #Networking
October 20, 2025 at 7:11 AM
It’s my greatest pleasure to co-organize this event! 🚀
PIs from Brno: come join us and see what this supportive initiative is all about! 🙌
#BrnoScience #YoungPIs #Networking
PIs from Brno: come join us and see what this supportive initiative is all about! 🙌
#BrnoScience #YoungPIs #Networking
Just finished an amazing EMBO Lab Leadership course! 50% of my excitement comes from the inspiring lecturers Aiden and Petra, and the other 50% from meeting 14 brilliant young PIs — the next generation of leading scientists in Europe.
October 17, 2025 at 12:26 PM
Just finished an amazing EMBO Lab Leadership course! 50% of my excitement comes from the inspiring lecturers Aiden and Petra, and the other 50% from meeting 14 brilliant young PIs — the next generation of leading scientists in Europe.
For all Xenopus lovers: the CSHL Xenopus Course is coming in 2026! 🐸
Led by the awesome @walenteklab.bsky.social & Rachel Miller. Don’t miss it! 💪 #frogpower
Led by the awesome @walenteklab.bsky.social & Rachel Miller. Don’t miss it! 💪 #frogpower
October 9, 2025 at 1:26 PM
For all Xenopus lovers: the CSHL Xenopus Course is coming in 2026! 🐸
Led by the awesome @walenteklab.bsky.social & Rachel Miller. Don’t miss it! 💪 #frogpower
Led by the awesome @walenteklab.bsky.social & Rachel Miller. Don’t miss it! 💪 #frogpower
Just wrapped up my first-ever poster presentation in BOTH English & Spanish 🎉 A truly fantastic experience! Learned that it’s not the poster itself that matters, but how we speak about science 🧪✨ Viva México! 🇲🇽
September 24, 2025 at 3:28 AM
Just wrapped up my first-ever poster presentation in BOTH English & Spanish 🎉 A truly fantastic experience! Learned that it’s not the poster itself that matters, but how we speak about science 🧪✨ Viva México! 🇲🇽
🇲🇽 Hola, buenos días from México! The VI Neurobiological Conference has just kicked off.
Excited to step out of my comfort zone and represent not only our lab at Masaryk University, not only Brno, not only Czechia… but maybe even Europe! 🌍
Greetings from the heart of wild & central Mexico!🧠
Excited to step out of my comfort zone and represent not only our lab at Masaryk University, not only Brno, not only Czechia… but maybe even Europe! 🌍
Greetings from the heart of wild & central Mexico!🧠
September 21, 2025 at 11:50 PM
🇲🇽 Hola, buenos días from México! The VI Neurobiological Conference has just kicked off.
Excited to step out of my comfort zone and represent not only our lab at Masaryk University, not only Brno, not only Czechia… but maybe even Europe! 🌍
Greetings from the heart of wild & central Mexico!🧠
Excited to step out of my comfort zone and represent not only our lab at Masaryk University, not only Brno, not only Czechia… but maybe even Europe! 🌍
Greetings from the heart of wild & central Mexico!🧠
Today I start the first lecture of my course Developmental defects (Bi1152en) at Masaryk University 🎓
My favorite part: to show how scientists in Mexico 🇲🇽 in 18–19th century were sometimes ahead of European colleagues, who were the “flagship” of science at that time. @jbwallingford.bsky.social
My favorite part: to show how scientists in Mexico 🇲🇽 in 18–19th century were sometimes ahead of European colleagues, who were the “flagship” of science at that time. @jbwallingford.bsky.social
September 16, 2025 at 9:04 AM
Today I start the first lecture of my course Developmental defects (Bi1152en) at Masaryk University 🎓
My favorite part: to show how scientists in Mexico 🇲🇽 in 18–19th century were sometimes ahead of European colleagues, who were the “flagship” of science at that time. @jbwallingford.bsky.social
My favorite part: to show how scientists in Mexico 🇲🇽 in 18–19th century were sometimes ahead of European colleagues, who were the “flagship” of science at that time. @jbwallingford.bsky.social
Reposted by Jakub Harnos lab
🔥Shout-out to everyone who taught at our Young Developmental Biologist Workshop @harnoslab.bsky.social, Pavel Kohout from @loschmidtlab.bsky.social, Viktória Parobková from @ceitec.eu, Irina Poverennaya from @meduniwien.ac.at, and Petr Vodička & David Drutovič from IAPG @czechacademy.bsky.social
September 14, 2025 at 6:44 PM
🔥Shout-out to everyone who taught at our Young Developmental Biologist Workshop @harnoslab.bsky.social, Pavel Kohout from @loschmidtlab.bsky.social, Viktória Parobková from @ceitec.eu, Irina Poverennaya from @meduniwien.ac.at, and Petr Vodička & David Drutovič from IAPG @czechacademy.bsky.social
🚨 Our collaborative paper on DNA structures in Xenopus oocytes is out! 🎉 Huge thanks to lead author Anirban Ghosh and PI Lukas Trantirek 🙌 #frogpower academic.oup.com/nar/article/...
Validate User
academic.oup.com
September 13, 2025 at 8:31 AM
🚨 Our collaborative paper on DNA structures in Xenopus oocytes is out! 🎉 Huge thanks to lead author Anirban Ghosh and PI Lukas Trantirek 🙌 #frogpower academic.oup.com/nar/article/...