Purpose of Review This article outlines the role of mitochondrial dynamics in healthy cells and elaborates on how blood cancer cells hijack these processes to support uncontrolled proliferation, stemn...

Targeting OPA1-mediated mitochondrial ultrastructural adaptations circumvents therapy resistance in acute leukemia.

Nature Reviews Clinical Oncology, Published online: 01 September 2025; doi:10.1038/s41571-025-01068-0Patients with acute myeloid leukaemia are often unable to tolerate intensive chemotherapy, and the outcomes of these patients have improved considerably following the availability of regimens containing the BH3 mimetic venetoclax. Nonetheless, not all of these patients will respond to venetoclax, and virtually all will ultimately develop resistance, indicating a need for novel treatment strategies targeting this pathway. In this Review, the authors describe the development of BCL-2 inhibitors, discuss mechanisms of resistance and summarize ongoing research efforts aimed at optimizing the therapeutic benefit of these agents.

Patients with acute myeloid leukaemia are often unable to tolerate intensive chemotherapy, and the outcomes of these patients have improved considerably following the availability of regimens containi...

Rigoni et al. use complexomic to develop two online-available tools, MARIGOLD and MitoCIAO, mapping mitochondrial protein interactions during membrane remodeling. MARIGOLD provides “digital western bl...

Mitochondria are multifunctional organelles that play a crucial role in numerous cellular processes, including oncogene-induced senescence. Recent studies have demonstrated that mitochondria undergo n...