Giulio Maria Pasinetti, MD, PhD
@giuliompasinetti.bsky.social
Creating a culture of innovation that emphasizes creativity, disruptive thinking, and interdisciplinary collaboration to understand and promote neuroresilience.
Pinned
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients
INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain-first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain u...
alz-journals.onlinelibrary.wiley.com
January 13, 2026 at 3:28 PM
In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...
January 12, 2026 at 2:58 PM
Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...
Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...
January 8, 2026 at 1:54 PM
Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...
Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
January 6, 2026 at 4:09 PM
Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain - Per Nilsson, Karin Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Lovisa Johanss...
Background Alzheimer's disease (AD) brains are characterized by increased levels of the pathogenic amyloid-β (Aβ) peptide, which accumulates into extracell...
journals.sagepub.com
January 5, 2026 at 2:33 PM
Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease.
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Learn More in Journal of Alzheimer’s Disease
journals.sagepub.com/doi/10.1177/...
Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
January 2, 2026 at 8:32 PM
Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
May the New Year bring you joy, happiness, peace and good health! 🎉
December 31, 2025 at 9:44 PM
May the New Year bring you joy, happiness, peace and good health! 🎉
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Chaubey et al. demonstrate that restoration of brain resilience reverses advanced
disease in two different mouse models of Alzheimer’s disease (AD), challenging the
century-long dogma of AD irreversib...
www.cell.com
December 29, 2025 at 7:24 PM
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
December 29, 2025 at 7:08 PM
Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
December 26, 2025 at 3:15 PM
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
The #PasinettiLab’s family wishes you and your loved ones an AMAZING HOLIDAY filled with #Peace, #Joy, #Love and #Happiness! Most importantly, we wish you the best of HEALTH. Please #StaySafe as you gather for holiday festivities.
December 23, 2025 at 6:10 PM
The #PasinettiLab’s family wishes you and your loved ones an AMAZING HOLIDAY filled with #Peace, #Joy, #Love and #Happiness! Most importantly, we wish you the best of HEALTH. Please #StaySafe as you gather for holiday festivities.
Researchers Huntington Potter, et al. @cuanschutz.bsky.social discovered while brain neuron changes may begin in early life, sargramostim might be repurposed to slow damage, offering new hope for those w/ #Alzheimers & other cognition issues @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
December 23, 2025 at 3:56 PM
Researchers Huntington Potter, et al. @cuanschutz.bsky.social discovered while brain neuron changes may begin in early life, sargramostim might be repurposed to slow damage, offering new hope for those w/ #Alzheimers & other cognition issues @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
December 22, 2025 at 1:31 PM
IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease - Nature Neuroscience
This study reveals how distal DNA ‘switches’ control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer–gene links, highlight Alzheimer’s disease-related...
www.nature.com
December 19, 2025 at 7:11 PM
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NEW RESEARCH from Jo Mhairi Hale, et al. 👉 Disentangling #SocialIsolation, #Loneliness & later-life cognitive function for older adults in United States: Evidence from causal inference modeling. @uniofstandrews.bsky.social @emoryuniversity.bsky.social FULL STUDY ➡️ academic.oup.com/psychsocgero...
December 18, 2025 at 2:44 PM
NEW RESEARCH from Jo Mhairi Hale, et al. 👉 Disentangling #SocialIsolation, #Loneliness & later-life cognitive function for older adults in United States: Evidence from causal inference modeling. @uniofstandrews.bsky.social @emoryuniversity.bsky.social FULL STUDY ➡️ academic.oup.com/psychsocgero...
The #PasinettiLab is excited to share its REVIEW "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression" ➡️ OUT NOW in Molecular Neurobiology👉 link.springer.com/article/10.1...
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
December 17, 2025 at 4:24 PM
The #PasinettiLab is excited to share its REVIEW "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression" ➡️ OUT NOW in Molecular Neurobiology👉 link.springer.com/article/10.1...
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
@mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social
Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is COMING UP FAST🚀 Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now👉 www.worldBrainMapping.org
December 17, 2025 at 2:45 PM
Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is COMING UP FAST🚀 Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now👉 www.worldBrainMapping.org
Here, Ana Royo Marco, et al. investigated whether promoting brain lymphatic drainage recuperation following #TBI via trtmnt w/ lymphangiogenic factor vessel endothelial growth factor C (VEGFC) mitigates ability of TBI to exacerbate tauopathy @cp-cellreports.bsky.social www.cell.com/cell-reports...
Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis
How traumatic brain injury (TBI) mechanistically contributes to neurodegenerative
disease remains poorly understood. Marco et al. find that therapeutic viral vector-based
delivery of VEGFC recuperates...
www.cell.com
December 16, 2025 at 8:29 PM
Here, Ana Royo Marco, et al. investigated whether promoting brain lymphatic drainage recuperation following #TBI via trtmnt w/ lymphangiogenic factor vessel endothelial growth factor C (VEGFC) mitigates ability of TBI to exacerbate tauopathy @cp-cellreports.bsky.social www.cell.com/cell-reports...
In this study, Matias Pizarro, Ruben Gomez-Gutierrez, et al. investigate the effects of infusing blood from young and old wild-type mice into transgenic mice that model #AlzheimersDisease brain amyloidosis. Learn More in Aging 👉 www.aging-us.com/article/206319
Infusion of blood from young and old mice modulates amyloid pathology | Aging
Aging | doi:10.18632/aging.206319. Matias Pizarro, Ruben Gomez-Gutierrez, Ariel Caviedes, Catalina Valdes, Ute Woehlbier, Cristian Vargas, Mauricio Hernandez, Claudia Duran-Aniotz, Rodrigo Morales
www.aging-us.com
December 12, 2025 at 8:36 PM
In this study, Matias Pizarro, Ruben Gomez-Gutierrez, et al. investigate the effects of infusing blood from young and old wild-type mice into transgenic mice that model #AlzheimersDisease brain amyloidosis. Learn More in Aging 👉 www.aging-us.com/article/206319
Researchers Chiron Bang, et al. @floridaatlantic.bsky.social have dvlped deep learning model that analyzes #Electroencephalography brain activity to detect both type & severity of #Dementia, specifically #AlzheimersDisease & #FrontotemporalDementia Learn More 👉 www.sciencedirect.com/science/arti...
Extraction and interpretation of EEG features for diagnosis and severity prediction of Alzheimer’s Disease and Frontotemporal dementia using deep learning
Alzheimer’s Disease (AD) is the most common form of dementia, characterized by progressive cognitive decline and memory loss. Frontotemporal dementia …
www.sciencedirect.com
December 11, 2025 at 2:40 PM
Researchers Chiron Bang, et al. @floridaatlantic.bsky.social have dvlped deep learning model that analyzes #Electroencephalography brain activity to detect both type & severity of #Dementia, specifically #AlzheimersDisease & #FrontotemporalDementia Learn More 👉 www.sciencedirect.com/science/arti...
Researchers Cyrus Raji, et al. @washumedmir.bsky.social have conducted 1st study evaluating impact of #Obesity on #Alzheimers blood #Biomarkers. BBM values increased up to 95% faster in individuals w/ obesity vs. non-obese individuals. Learn More @rsnasky.bsky.social 👉 www.rsna.org/media/press/...
December 10, 2025 at 10:11 PM
Researchers Cyrus Raji, et al. @washumedmir.bsky.social have conducted 1st study evaluating impact of #Obesity on #Alzheimers blood #Biomarkers. BBM values increased up to 95% faster in individuals w/ obesity vs. non-obese individuals. Learn More @rsnasky.bsky.social 👉 www.rsna.org/media/press/...
This review by Kamal Dua, Muralikrishnan Dhanasekaran, et al. explores the emerging link between #Microplastics exposure & development of #NeurodegenerativeDiseases, particularly #Alzheimers & #ParkinsonsDisease. Learn More in Molecular and Cellular Biochemistry 👉 link.springer.com/article/10.1...
Do microplastics play a role in the pathogenesis of neurodegenerative diseases? Shared pathophysiological pathways for Alzheimer’s and Parkinson’s disease - Molecular and Cellular Biochemistry
The widespread presence of microplastics (MPs) in the environment has raised significant concerns about their potential impact on human health. As of 2023, the Ocean Conservancy estimates that adults ...
link.springer.com
December 9, 2025 at 3:07 PM
This review by Kamal Dua, Muralikrishnan Dhanasekaran, et al. explores the emerging link between #Microplastics exposure & development of #NeurodegenerativeDiseases, particularly #Alzheimers & #ParkinsonsDisease. Learn More in Molecular and Cellular Biochemistry 👉 link.springer.com/article/10.1...
Scientists Erzsebet Szatmari, Ryohei Yasuda, et al.
@mpfneuro.bsky.social w/ @eastcarolinauniv.bsky.social & @floridaatlantic.bsky.social 👉 genetically eliminating Centaurin-α1 can lessen many of cognitive deficits & brain damage caused by #Alzheimers in mice. eNeuro www.eneuro.org/content/12/1...
@mpfneuro.bsky.social w/ @eastcarolinauniv.bsky.social & @floridaatlantic.bsky.social 👉 genetically eliminating Centaurin-α1 can lessen many of cognitive deficits & brain damage caused by #Alzheimers in mice. eNeuro www.eneuro.org/content/12/1...
Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
ArfGAP, with dual PH domain-containing protein 1/Centaurin-α1 (ADAP1/CentA1), is a brain-enriched and highly conserved Arf6 GTPase-activating and Ras-anchoring protein. CentA1 is involved in dendritic...
www.eneuro.org
December 8, 2025 at 4:23 PM
Scientists Erzsebet Szatmari, Ryohei Yasuda, et al.
@mpfneuro.bsky.social w/ @eastcarolinauniv.bsky.social & @floridaatlantic.bsky.social 👉 genetically eliminating Centaurin-α1 can lessen many of cognitive deficits & brain damage caused by #Alzheimers in mice. eNeuro www.eneuro.org/content/12/1...
@mpfneuro.bsky.social w/ @eastcarolinauniv.bsky.social & @floridaatlantic.bsky.social 👉 genetically eliminating Centaurin-α1 can lessen many of cognitive deficits & brain damage caused by #Alzheimers in mice. eNeuro www.eneuro.org/content/12/1...
Why do neurons die in #Dementia & can this process be slowed down? Study by researchers Svenja Lorenz, Marcus Conrad, et al. provides the first molecular evidence that #Ferroptosis can drive #Neurodegeneration in the human brain. Learn More @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 5, 2025 at 6:19 PM
Why do neurons die in #Dementia & can this process be slowed down? Study by researchers Svenja Lorenz, Marcus Conrad, et al. provides the first molecular evidence that #Ferroptosis can drive #Neurodegeneration in the human brain. Learn More @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Large population analysis by Min Xie, Pascal Geldsetzer, et al. @stanforduniversity.bsky.social strengthens growing evidence that viral infections may play an important and previously underappreciated role in #NeurodegenerativeDisease. Learn More @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...
December 3, 2025 at 1:41 PM
Large population analysis by Min Xie, Pascal Geldsetzer, et al. @stanforduniversity.bsky.social strengthens growing evidence that viral infections may play an important and previously underappreciated role in #NeurodegenerativeDisease. Learn More @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...