LightNews LightNews
genomicspat.bsky.social
@genomicspat.bsky.social
20 followers 71 following 120 posts
Posts Replies Media Videos
genomicspat.bsky.social
x.com/diagnostic_m...
Diagnostics MDPI on X: "🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB" / X
🎊First article published in the Special Issue 'Point-of-Care Testing (#POCT) for Infectious Diseases' "An ERA-CRISPR/Cas12a Method for Highly Sensitive Detection of Human #Adenovirus Type 55" by Letian Zhang et al. 📖Check out the full publication at https://t.co/7BA6Ggc7SO https://t.co/LZvZ7DIAIB
x.com
October 30, 2025 at 11:50 PM
genomicspat.bsky.social
www.sciencedirect.com/science/arti...
Weakly supervised deep learning-based detection of serous tubal intraepithelial carcinoma in fallopian tubes
Serous tubal intraepithelial carcinoma (STIC) is an uncommon, non-invasive carcinoma that occurs more frequently in individuals with germline BRCA mut…
www.sciencedirect.com
October 30, 2025 at 11:46 PM
genomicspat.bsky.social
Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control url:https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-25-0351/762071/Adaptive-Therapy-Exploits-Fitness-Deficits-in
May 8, 2025 at 12:57 AM
genomicspat.bsky.social
Correlation between EpCAM expression and cervical lymph node metastasis in papillary thyroid carcinoma: a study integrating ultrasonographic features - BMC Cancer
Objectives The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that is overexpressed in various epithelial tumors and has been associated with tumor aggressiveness and unfavo...
bmccancer.biomedcentral.com
April 30, 2025 at 11:14 AM
genomicspat.bsky.social
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...
www.cell.com
April 15, 2025 at 2:49 AM
genomicspat.bsky.social
Endocrine Therapy Omission in Estrogen Receptor–Low (1%-10%) Early-Stage Breast Cancer
PURPOSEAdjuvant endocrine therapy (ET) improves overall survival (OS) in estrogen receptor (ER)–positive early-stage breast cancer (BC). However, the benefit of ET for those with ER-low BC (ER 1%-10%)...
ascopubs.org
April 15, 2025 at 2:45 AM
genomicspat.bsky.social
www.kcl.ac.uk/news/study-s...
Study shows how new antibody therapy works against ovarian cancer
Research has shed light on how a new type of antibody treatment reactivates patients’ immune cells to fight ovarian cancer.
www.kcl.ac.uk
April 12, 2025 at 12:44 PM
genomicspat.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage
We show that specific histological patterns of prostatic adenocarcinoma are highly sensitive for predicting metastatic potential, independent of grade group and pathological staging. We propose a sim....
onlinelibrary.wiley.com
April 9, 2025 at 2:22 AM
genomicspat.bsky.social
Prognostic importance of direct assignment of parent of origin via long-read genome and epigenome sequencing in retinoblastoma
JCI Insight - Prognostic importance of direct assignment of parent of origin via long-read genome and epigenome sequencing in retinoblastoma
insight.jci.org
April 9, 2025 at 12:48 AM
genomicspat.bsky.social
www.nature.com/articles/s41...
An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma - Nature Medicine
A preinfusion circulatory inflammation biomarker-based signature predicts the likelihood of treatment failure in patients with non-Hodgkin lymphoma who were treated with CAR-T cell therapy, with an in...
www.nature.com
April 2, 2025 at 11:53 AM
genomicspat.bsky.social
www.esmoopen.com/article/S205...
Prognosis, clinicopathological characteristics, and treatment patterns of patients with ER-intermediate-positive breast cancer undergoing long-term follow-up
Estrogen receptor (ER) expression levels in breast cancer tissue predict the efficacy of endocrine therapy and the prognosis of breast cancer patients. Recently, it was reported that the prognosis of ...
www.esmoopen.com
April 1, 2025 at 1:14 PM
genomicspat.bsky.social
www.science.org/doi/10.1126/...
An in vivo screen identifies NAT10 as a master regulator of brain metastasis
NAT10 is identified as a master regulator of brain metastasis and a potential target for treating metastasis.
www.science.org
March 31, 2025 at 5:12 PM
genomicspat.bsky.social
www.biorxiv.org/content/10.1...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it r...
www.biorxiv.org
March 28, 2025 at 11:18 AM
genomicspat.bsky.social
journals.plos.org/plosone/arti...
The role of renal and liver function in clinical ctDNA testing
Circulating tumor DNA (ctDNA) has high clinical potential in early cancer detection. The renal system and the liver are involved in clearing circulating cell free DNA (cfDNA) from the blood. Recent st...
journals.plos.org
March 27, 2025 at 12:44 PM
genomicspat.bsky.social
www.sciencedirect.com/science/arti...
Immunophenotype of CAR T cells and apheresis products predicts response in CD22 CAR T cell trial for B cell acute lymphoblastic leukemia
Although CAR T cell therapy is increasingly used to treat relapsed B cell acute lymphoblastic leukemia (ALL), 20%–30% of patients do not respond, and …
www.sciencedirect.com
March 27, 2025 at 12:55 AM
genomicspat.bsky.social
www.jmdjournal.org/article/S152...
Deciphering Genomic Complexity of Multiple Myeloma Using Optimized Optical Genome Mapping
The genomic evaluation of multiple myeloma in routine diagnostics involves isolating plasma cells expressing CD138, usually followed by fluorescence in situ hybridization analyses. However, cell sorti...
www.jmdjournal.org
March 26, 2025 at 10:39 PM
genomicspat.bsky.social
www.jmdjournal.org/article/S152...
Comparison of targeted RNA sequencing platforms for oncogenic fusion detection in non-small cell lung cancer
Oncogenic fusion detection is an essential part of clinical diagnosis and management of non-small cell lung carcinoma. Numerous methods are available for detection of oncogenic fusions in the clinical...
www.jmdjournal.org
March 23, 2025 at 3:42 AM
genomicspat.bsky.social
www.nature.com/articles/s41...
γδ T cells as sensors of ectopically expressed intracellular proteins - Cellular & Molecular Immunology
Cellular & Molecular Immunology - γδ T cells as sensors of ectopically expressed intracellular proteins
www.nature.com
March 21, 2025 at 3:38 PM
genomicspat.bsky.social
Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies - Journal of Hematology & Oncology
Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of patients with relapsed/refractory (R/R) hematologic malignancies, including B-cell lymphomas and multiple myeloma (MM...
jhoonline.biomedcentral.com
March 20, 2025 at 12:15 PM
genomicspat.bsky.social
www.nature.com/articles/s41...
Quantitative characterization of cell niches in spatially resolved omics data - Nature Genetics
NicheCompass is a graph variational autoencoder approach for identifying cellular niches defined by cell–cell communication and other interactions, applicable to a broad variety of spatial multi-omic ...
www.nature.com
March 18, 2025 at 11:15 AM
Reposted
elisabettabonzano.bsky.social
Oncology HERE & NOW Webcast/Podcast Now Out, JOIN OncoAlert Faulty🚨 Dr. @elisaagostinetto.bsky.social 🇧🇪& Dr. @maryamlustberg.bsky.social 🇺🇸 as they dive into #BreastCancer and the use of adj CDK 4/6 inhibitors and more

youtu.be/zw8vYd894jI

Podcasts : buzzsprout.com/1324033/epis...
March 14, 2025 at 6:27 PM
genomicspat.bsky.social
Long read sequencing enhances pathogenic and novel variation discovery in patients with rare diseases - Nature Communications
Here the authors illustrate how long read whole genome sequencing can enhance the diagnosis of patients with rare diseases relative to standard methods, through identification of comprehensive small a...
www.nature.com
March 14, 2025 at 6:39 PM
genomicspat.bsky.social
Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy - Leukemia
Leukemia - Cerebrospinal fluid proteomics exerts predictive potential for immune effector cell-associated neurotoxicity syndrome (ICANS) in CAR-T cell therapy
www.nature.com
March 11, 2025 at 12:29 PM
genomicspat.bsky.social
jcp.bmj.com/content/78/3...
Emerging fusion-associated mesenchymal tumours: a tabular guide and appraisal of five ‘novel’ entities
Aims The field of molecular pathology has undergone significant advancements in the clinical impact of sarcoma diagnosis, resulting in challenges to nosology of bone and soft tissue tumours. The surge...
jcp.bmj.com
March 9, 2025 at 7:31 PM
genomicspat.bsky.social
www.nature.com/articles/s41...
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications
Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...
www.nature.com
March 6, 2025 at 7:49 PM