GastroAGI
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Empowering clinicians & trainees with expert GI & liver updates, clinical pearls & trending research.
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GastroAGI | January 2026 Updates
Explore the latest high-impact research in gastroenterology and hepatology from leading journals. Log in, click Trending Topics, and stay updated with January 2026 insights.
🧠 gastroagi.com
Explore the latest high-impact research in gastroenterology and hepatology from leading journals. Log in, click Trending Topics, and stay updated with January 2026 insights.
🧠 gastroagi.com
Vonoprazan Dual
Therapy for H. pylori
January 30, 2026 at 8:09 AM
Vonoprazan Dual
Therapy for H. pylori
Metastasis-Directed Therapy
January 30, 2026 at 8:08 AM
Metastasis-Directed Therapy
January 30, 2026 at 8:02 AM
Nutrition in Cirrhosis & Liver Transplant
#GastroAGI #Hepatology #Cirrhosis #LiverTransplant #Nutrition #Sarcopenia #Frailty #Prehabilitation #TransplantMedicine #LiverDisease
#GastroAGI #Hepatology #Cirrhosis #LiverTransplant #Nutrition #Sarcopenia #Frailty #Prehabilitation #TransplantMedicine #LiverDisease
January 30, 2026 at 8:01 AM
Nutrition in Cirrhosis & Liver Transplant
#GastroAGI #Hepatology #Cirrhosis #LiverTransplant #Nutrition #Sarcopenia #Frailty #Prehabilitation #TransplantMedicine #LiverDisease
#GastroAGI #Hepatology #Cirrhosis #LiverTransplant #Nutrition #Sarcopenia #Frailty #Prehabilitation #TransplantMedicine #LiverDisease
Human Albumin in Cirrhosis
#GastroAGI #Hepatology #Cirrhosis #Albumin #LiverDisease #HRS #Ascites #SBP
#GastroAGI #Hepatology #Cirrhosis #Albumin #LiverDisease #HRS #Ascites #SBP
January 30, 2026 at 8:00 AM
Human Albumin in Cirrhosis
#GastroAGI #Hepatology #Cirrhosis #Albumin #LiverDisease #HRS #Ascites #SBP
#GastroAGI #Hepatology #Cirrhosis #Albumin #LiverDisease #HRS #Ascites #SBP
🔬 STAD study links lactylation-related genes to tumor biology
🧬 6-gene model predicts survival; DHRS7 key
⬇️ Low early, 🔼 higher in advanced disease → worse outcomes
🧩 DHRS7 tied to M2 macrophages, PI3K-AKT & TGF-β
🎯 Potential prognostic biomarker & therapeutic target
#gastroenterology
🧬 6-gene model predicts survival; DHRS7 key
⬇️ Low early, 🔼 higher in advanced disease → worse outcomes
🧩 DHRS7 tied to M2 macrophages, PI3K-AKT & TGF-β
🎯 Potential prognostic biomarker & therapeutic target
#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
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January 20, 2026 at 12:41 PM
🔬 STAD study links lactylation-related genes to tumor biology
🧬 6-gene model predicts survival; DHRS7 key
⬇️ Low early, 🔼 higher in advanced disease → worse outcomes
🧩 DHRS7 tied to M2 macrophages, PI3K-AKT & TGF-β
🎯 Potential prognostic biomarker & therapeutic target
#gastroenterology
🧬 6-gene model predicts survival; DHRS7 key
⬇️ Low early, 🔼 higher in advanced disease → worse outcomes
🧩 DHRS7 tied to M2 macrophages, PI3K-AKT & TGF-β
🎯 Potential prognostic biomarker & therapeutic target
#gastroenterology
🔴 Canadian pediatric obesity guideline = major shift
🟩 Obesity framed as chronic disease, not lifestyle failure
🔷 Prioritizes mental health & QoL over weight alone
🟡 Tiered care: lifestyle/psych; meds ≥12y; bariatric surgery severe cases
🟣 Calls for national funding & equitable access
🟩 Obesity framed as chronic disease, not lifestyle failure
🔷 Prioritizes mental health & QoL over weight alone
🟡 Tiered care: lifestyle/psych; meds ≥12y; bariatric surgery severe cases
🟣 Calls for national funding & equitable access
GastroAGI - AI Chat for Gastroenterology Students
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January 20, 2026 at 12:39 PM
🔴 Canadian pediatric obesity guideline = major shift
🟩 Obesity framed as chronic disease, not lifestyle failure
🔷 Prioritizes mental health & QoL over weight alone
🟡 Tiered care: lifestyle/psych; meds ≥12y; bariatric surgery severe cases
🟣 Calls for national funding & equitable access
🟩 Obesity framed as chronic disease, not lifestyle failure
🔷 Prioritizes mental health & QoL over weight alone
🟡 Tiered care: lifestyle/psych; meds ≥12y; bariatric surgery severe cases
🟣 Calls for national funding & equitable access
🔴 HER2+ = poorer prognosis in mCRC
🟠 ~5% have HER2 amplification; ~2% mutation
🟡 Shorter survival vs HER2− disease
🟢 Response to bevacizumab or anti-EGFR similar
🔵 Supports need for HER2-targeted therapy in mCRC
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#gastroenterology
🟠 ~5% have HER2 amplification; ~2% mutation
🟡 Shorter survival vs HER2− disease
🟢 Response to bevacizumab or anti-EGFR similar
🔵 Supports need for HER2-targeted therapy in mCRC
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#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
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January 20, 2026 at 12:38 PM
🔴 HER2+ = poorer prognosis in mCRC
🟠 ~5% have HER2 amplification; ~2% mutation
🟡 Shorter survival vs HER2− disease
🟢 Response to bevacizumab or anti-EGFR similar
🔵 Supports need for HER2-targeted therapy in mCRC
🧠 gastroagi.com/chat
#gastroenterology
🟠 ~5% have HER2 amplification; ~2% mutation
🟡 Shorter survival vs HER2− disease
🟢 Response to bevacizumab or anti-EGFR similar
🔵 Supports need for HER2-targeted therapy in mCRC
🧠 gastroagi.com/chat
#gastroenterology
MAPK signaling drives GI disease: ERK promotes tumor growth in CRC & gastric cancer; JNK & p38 drive inflammation, apoptosis & fibrosis in IBD and pancreatitis. Targeted MEK, JNK & p38 inhibitors show promise, but resistance and off-target effects remain challenges.
#gastroenterology
#gastroenterology
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January 16, 2026 at 11:24 AM
MAPK signaling drives GI disease: ERK promotes tumor growth in CRC & gastric cancer; JNK & p38 drive inflammation, apoptosis & fibrosis in IBD and pancreatitis. Targeted MEK, JNK & p38 inhibitors show promise, but resistance and off-target effects remain challenges.
#gastroenterology
#gastroenterology
🔬 THR-β agonists are reshaping MASH therapy. 📌 Resmetirom (MAESTRO-NASH) improved MASH resolution & fibrosis vs placebo and ↓ liver fat with better lipids. 🧪 VK2809 shows similar fat reduction. ⚠️ Long-term & cirrhosis outcomes pending, but THR-β is now validated.
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Ask AI-powered questions about gastroenterology and enhance your academic learning.
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January 16, 2026 at 11:23 AM
🔬 THR-β agonists are reshaping MASH therapy. 📌 Resmetirom (MAESTRO-NASH) improved MASH resolution & fibrosis vs placebo and ↓ liver fat with better lipids. 🧪 VK2809 shows similar fat reduction. ⚠️ Long-term & cirrhosis outcomes pending, but THR-β is now validated.
🧠 gastroagi.com/chat
🧠 gastroagi.com/chat
ACLF East vs West: APASL—acute insult in CLD → jaundice/INR, liver failure first; HBV common; focus on liver rescue (antivirals, PE, albumin). AASLD/CLIF—decomp cirrhosis w/ multiorgan failure; sepsis/alcohol common; ICU + early LT. Synthesis needed.
#GastroAGI#AASLD2025#ACLF
#GastroAGI#AASLD2025#ACLF
GastroAGI - AI Chat for Gastroenterology Students
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January 16, 2026 at 11:23 AM
ACLF East vs West: APASL—acute insult in CLD → jaundice/INR, liver failure first; HBV common; focus on liver rescue (antivirals, PE, albumin). AASLD/CLIF—decomp cirrhosis w/ multiorgan failure; sepsis/alcohol common; ICU + early LT. Synthesis needed.
#GastroAGI#AASLD2025#ACLF
#GastroAGI#AASLD2025#ACLF
🔥 TGF-β in chronic pancreatitis: key driver of fibrosis via pancreatic stellate cell activation. 🧬 Promotes collagen deposition, EMT & profibrotic immune responses. 💊 Targeting TGF-β (pirfenidone, NAC, blockers) shows antifibrotic promise.
#gastroenterology
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#gastroenterology
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January 16, 2026 at 11:22 AM
🔥 TGF-β in chronic pancreatitis: key driver of fibrosis via pancreatic stellate cell activation. 🧬 Promotes collagen deposition, EMT & profibrotic immune responses. 💊 Targeting TGF-β (pirfenidone, NAC, blockers) shows antifibrotic promise.
#gastroenterology
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#gastroenterology
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🔬 Machine perfusion in liver transplant keeps donor livers metabolically active. ❄️ HMP reduces ischemia. 🌡️ NMP enables real-time functional assessment. 🧠 Allows use of steatotic, DCD & elderly grafts. 📈 Expands donor pool. 🔮 Future: organ repair, gene therapy & improved logistics.
GastroAGI - AI Chat for Gastroenterology Students
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January 16, 2026 at 11:20 AM
🔬 Machine perfusion in liver transplant keeps donor livers metabolically active. ❄️ HMP reduces ischemia. 🌡️ NMP enables real-time functional assessment. 🧠 Allows use of steatotic, DCD & elderly grafts. 📈 Expands donor pool. 🔮 Future: organ repair, gene therapy & improved logistics.
PERT in EPI (ACG): Start PERT at diagnosis—don’t wait for severe sx or deficits. Multidisciplinary care incl nutrition + endo. Diet: low–moderate fat, small frequent meals; screen vitamins annually. Dx: fecal elastase best; imaging not diagnostic. Monitor nutrition + DEXA q1–2y.
#gastroenterology
#gastroenterology
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January 16, 2026 at 11:19 AM
PERT in EPI (ACG): Start PERT at diagnosis—don’t wait for severe sx or deficits. Multidisciplinary care incl nutrition + endo. Diet: low–moderate fat, small frequent meals; screen vitamins annually. Dx: fecal elastase best; imaging not diagnostic. Monitor nutrition + DEXA q1–2y.
#gastroenterology
#gastroenterology
Pancreatic SBRT shows low 90-day mortality. 🦠 Infections drive many admissions. ⚠️ Late severe GI toxicity is higher without prior surgery and with high-BED dosing. 🔎 Future SBRT trials need long-term follow-up to capture late toxicities.
#gastroenterology
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#gastroenterology
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GastroAGI - AI Chat for Gastroenterology Students
Ask AI-powered questions about gastroenterology and enhance your academic learning.
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January 16, 2026 at 11:18 AM
Pancreatic SBRT shows low 90-day mortality. 🦠 Infections drive many admissions. ⚠️ Late severe GI toxicity is higher without prior surgery and with high-BED dosing. 🔎 Future SBRT trials need long-term follow-up to capture late toxicities.
#gastroenterology
🧠 gastroagi.com/chat
#gastroenterology
🧠 gastroagi.com/chat
January 16, 2026 at 10:30 AM
Programmed cell death inhibitors in liver disease: Apoptosis blockers ↓ hepatocyte loss but need cancer monitoring. (RIPK1/3) inhibitors ↓ inflammation & fibrosis in MASLD/MASH.NLRP3 inhibitors ↓ IL-1β/IL-18. Ferroptosis inhibitors limit lipid peroxidation in MASH & I/R.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:58 AM
Programmed cell death inhibitors in liver disease: Apoptosis blockers ↓ hepatocyte loss but need cancer monitoring. (RIPK1/3) inhibitors ↓ inflammation & fibrosis in MASLD/MASH.NLRP3 inhibitors ↓ IL-1β/IL-18. Ferroptosis inhibitors limit lipid peroxidation in MASH & I/R.
#gastroenterology
#gastroenterology
Endothelial cells control liver zonation & regeneration: Zone 1 LSECs make Wnt inhibitors → gluconeogenesis & oxidative metabolism. Zone 3 LSECs make Wnt2/Wnt9b → detox & lipid metabolism. Injury: LSECs release HGF, VEGF & Wnt. Damage impairs repair, promotes fibrosis.
#gastroenterology
#gastroenterology
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January 16, 2026 at 9:50 AM
Endothelial cells control liver zonation & regeneration: Zone 1 LSECs make Wnt inhibitors → gluconeogenesis & oxidative metabolism. Zone 3 LSECs make Wnt2/Wnt9b → detox & lipid metabolism. Injury: LSECs release HGF, VEGF & Wnt. Damage impairs repair, promotes fibrosis.
#gastroenterology
#gastroenterology
miR147 protects gut mucosa by maintaining epithelial integrity and limiting inflammation. Knockout causes severe colitis, barrier loss, ↑ permeability. Targets Ndufa4 to regulate metabolism + type I IFN signaling. Therapeutic potential in IBD & colorectal cancer.
#gastroenterology
#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
Ask AI-powered questions about gastroenterology and enhance your academic learning.
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January 16, 2026 at 9:49 AM
miR147 protects gut mucosa by maintaining epithelial integrity and limiting inflammation. Knockout causes severe colitis, barrier loss, ↑ permeability. Targets Ndufa4 to regulate metabolism + type I IFN signaling. Therapeutic potential in IBD & colorectal cancer.
#gastroenterology
#gastroenterology
COBALT (PBC): Despite early termination, adjusted analyses + real-world external controls showed obeticholic acid reduced major liver events. EC analysis showed lower risk of death, LT, or decompensation. Well tolerated; pruritus most common. Shows value of hybrid RCT + RWE.
#gastroenterology
#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
Ask AI-powered questions about gastroenterology and enhance your academic learning.
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January 16, 2026 at 9:48 AM
COBALT (PBC): Despite early termination, adjusted analyses + real-world external controls showed obeticholic acid reduced major liver events. EC analysis showed lower risk of death, LT, or decompensation. Well tolerated; pruritus most common. Shows value of hybrid RCT + RWE.
#gastroenterology
#gastroenterology
ML is transforming GI endoscopy: CADe boosts adenoma detection. CADx improves lesion classification & risk prediction. AI automates image analysis, annotation & reporting. Challenges: bias, artefacts, expert labels, real-time use. Future: LLMs+CV for precision & scalability.
#gastroenterology
#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
Ask AI-powered questions about gastroenterology and enhance your academic learning.
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January 16, 2026 at 9:47 AM
ML is transforming GI endoscopy: CADe boosts adenoma detection. CADx improves lesion classification & risk prediction. AI automates image analysis, annotation & reporting. Challenges: bias, artefacts, expert labels, real-time use. Future: LLMs+CV for precision & scalability.
#gastroenterology
#gastroenterology
January 16, 2026 at 7:41 AM
An SVM-based ML model predicts postoperative recurrence in ESCC. Using clinical, lab, and pathologic factors, the SVM6+8 model achieved high sensitivity. A nomogram estimates 1-, 3-, 5-yr DFS, enabling risk stratification and personalized follow-up/adjuvant therapy.
#gastroenterology
#gastroenterology
GastroAGI - AI Chat for Gastroenterology Students
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January 15, 2026 at 11:58 AM
An SVM-based ML model predicts postoperative recurrence in ESCC. Using clinical, lab, and pathologic factors, the SVM6+8 model achieved high sensitivity. A nomogram estimates 1-, 3-, 5-yr DFS, enabling risk stratification and personalized follow-up/adjuvant therapy.
#gastroenterology
#gastroenterology