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Spatial and temporal control of subcellular Ca²⁺ events in megakaryocytes and platelets using a highly Ca²⁺-conductive channelrhodopsin.
Full article link： rdcu.be/eP7tJ
Full article link： rdcu.be/eP7tJ
Optogenetic induction of subcellular Ca2+ events in megakaryocytes and platelets using a highly Ca2+-conductive channelrhodopsin
Communications Biology - The authors present a novel channel rhodopsin variant with enhanced Ca2+ conductance in megakaryocytes and platelets.
rdcu.be
November 15, 2025 at 10:06 PM
Spatial and temporal control of subcellular Ca²⁺ events in megakaryocytes and platelets using a highly Ca²⁺-conductive channelrhodopsin.
Full article link： rdcu.be/eP7tJ
Full article link： rdcu.be/eP7tJ
Why are the Potassium Channelrhodopsins (KCRs) sometimes leading to activation? Which KCR variant can achieve more reliable inhibition? We answered these two questions in our new paper.
A great collaboration from four labs.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
A great collaboration from four labs.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na...
advanced.onlinelibrary.wiley.com
November 12, 2025 at 9:13 AM
Why are the Potassium Channelrhodopsins (KCRs) sometimes leading to activation? Which KCR variant can achieve more reliable inhibition? We answered these two questions in our new paper.
A great collaboration from four labs.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
A great collaboration from four labs.
advanced.onlinelibrary.wiley.com/doi/10.1002/...
In our latest review, we traced the fascinating journey of optogenetics, from its origins to recent breakthroughs, and explored where the light will lead us next. advanced.onlinelibrary.wiley.com/doi/full/10....
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead
Optogenetics provides up to millisecond scale, cell type-specific control of biology using light-sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins ....
advanced.onlinelibrary.wiley.com
October 1, 2025 at 9:21 AM
In our latest review, we traced the fascinating journey of optogenetics, from its origins to recent breakthroughs, and explored where the light will lead us next. advanced.onlinelibrary.wiley.com/doi/full/10....
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06) - Duan - 2025 - Advanced Genetics - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06)
Illuminating Life with Optogenetics Beams of light orchestrate cellular control: light-gated ion channels shape ion flux; photoswitchable enzymes and receptors modulate signaling pathways; light-cont....
advanced.onlinelibrary.wiley.com
October 1, 2025 at 9:20 AM
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06) - Duan - 2025 - Advanced Genetics - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...
Congartulations！ Very nice work and beautiful cover picture. Targeted MYC2 stabilization confers citrus Huanglongbing resistance | Science www.science.org/doi/10.1126/...
Targeted MYC2 stabilization confers citrus Huanglongbing resistance
Huanglongbing (HLB) is a devastating citrus disease. In this work, we report an HLB resistance regulatory circuit in Citrus composed of an E3 ubiquitin ligase, PUB21, and its substrate, the MYC2 trans...
www.science.org
April 15, 2025 at 4:58 AM
Congartulations！ Very nice work and beautiful cover picture. Targeted MYC2 stabilization confers citrus Huanglongbing resistance | Science www.science.org/doi/10.1126/...