Fulcrum Genomics
@fulcrumgenomics.com
We provide specialized bioinformatic services to advance your technology and the understanding of human disease.
https://www.fulcrumgenomics.com
https://www.fulcrumgenomics.com
Today we feature a teammate balancing rigor and delivery in complex projects. He shares views on data-driven development, disciplined iteration, and connecting lab and computational teams. We hope you’ll feel like you’ve met us — or want to.
Meet Matt Stone: blog.fulcrumgenomics.com/p/meet-matt-...
Meet Matt Stone: blog.fulcrumgenomics.com/p/meet-matt-...
Meet Matt Stone
Head of Single-Cell and Spatial Sequencing
blog.fulcrumgenomics.com
January 9, 2026 at 5:39 PM
Today we feature a teammate balancing rigor and delivery in complex projects. He shares views on data-driven development, disciplined iteration, and connecting lab and computational teams. We hope you’ll feel like you’ve met us — or want to.
Meet Matt Stone: blog.fulcrumgenomics.com/p/meet-matt-...
Meet Matt Stone: blog.fulcrumgenomics.com/p/meet-matt-...
Which shift are you most excited (or skeptical) about?
Planning a stack upgrade? We’d love to collaborate.
Planning a stack upgrade? We’d love to collaborate.
December 30, 2025 at 6:32 PM
Which shift are you most excited (or skeptical) about?
Planning a stack upgrade? We’d love to collaborate.
Planning a stack upgrade? We’d love to collaborate.
Genomics is set for a big 2026: AI agents, GA4GH standards, Rust‑native workflows, long reads/ECS/SVs, and protein sequencing + AI design.
December 30, 2025 at 6:32 PM
Genomics is set for a big 2026: AI agents, GA4GH standards, Rust‑native workflows, long reads/ECS/SVs, and protein sequencing + AI design.
You made 2025 a great year @moonlight.bio, Juliann Chmielecki, @geoffjentry.bsky.social, Yossi Farjoun, Alison Meynert, Zach Norgaard, @msto.bsky.social, Ted Brookings, Jason Fan, Erin McAuley, Jess Smith, Tim Dunn, @charlottetolonen.bsky.social, @nilshomer.com, @tfenne.bsky.social
December 19, 2025 at 8:32 PM
You made 2025 a great year @moonlight.bio, Juliann Chmielecki, @geoffjentry.bsky.social, Yossi Farjoun, Alison Meynert, Zach Norgaard, @msto.bsky.social, Ted Brookings, Jason Fan, Erin McAuley, Jess Smith, Tim Dunn, @charlottetolonen.bsky.social, @nilshomer.com, @tfenne.bsky.social
Thank you to our clients - for the challenging problems, the good questions, and the partnerships.
Thank you to our team - for showing up with curiosity, rigor, and heart every single day.
Thank you to our team - for showing up with curiosity, rigor, and heart every single day.
December 19, 2025 at 8:22 PM
Thank you to our clients - for the challenging problems, the good questions, and the partnerships.
Thank you to our team - for showing up with curiosity, rigor, and heart every single day.
Thank you to our team - for showing up with curiosity, rigor, and heart every single day.
MutSeqR offers variant filtering, mutation frequency analysis, dose-response modeling, and spectrum analysis, all in a transparent, reproducible framework.
📄 Paper: doi.org/10.1093/bioa...
💻 Code: github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
#OpenScience #Genomics
📄 Paper: doi.org/10.1093/bioa...
💻 Code: github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
#OpenScience #Genomics
December 10, 2025 at 11:19 AM
MutSeqR offers variant filtering, mutation frequency analysis, dose-response modeling, and spectrum analysis, all in a transparent, reproducible framework.
📄 Paper: doi.org/10.1093/bioa...
💻 Code: github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
#OpenScience #Genomics
📄 Paper: doi.org/10.1093/bioa...
💻 Code: github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
#OpenScience #Genomics
ICYMI: Last week we announced MutSeqR, an open-source R package for error-corrected sequencing analysis, co-authored by our own Clint Valentine with Health Canada and U Ottawa.
It brings much-needed standardization to genetic toxicology research.
🧬 🖥️ blog.fulcrumgenomics.com/p/mutseqr-op...
It brings much-needed standardization to genetic toxicology research.
🧬 🖥️ blog.fulcrumgenomics.com/p/mutseqr-op...
MutSeqR: Open Standards for Error-Corrected Sequencing Analysis
Standardizing Error-Corrected Sequencing Data Analysis
blog.fulcrumgenomics.com
December 10, 2025 at 11:18 AM
ICYMI: Last week we announced MutSeqR, an open-source R package for error-corrected sequencing analysis, co-authored by our own Clint Valentine with Health Canada and U Ottawa.
It brings much-needed standardization to genetic toxicology research.
🧬 🖥️ blog.fulcrumgenomics.com/p/mutseqr-op...
It brings much-needed standardization to genetic toxicology research.
🧬 🖥️ blog.fulcrumgenomics.com/p/mutseqr-op...
We’ve contributed to open-source ECS software, including tools like fgbio and fastquorum, so this collaboration means a lot.
🔗https://github.com/fulcrumgenomics/fgbio
🔗https://github.com/nf-core/fastquorum
Standardization supports science and public health!
#Reproducibility #OpenScience
🔗https://github.com/fulcrumgenomics/fgbio
🔗https://github.com/nf-core/fastquorum
Standardization supports science and public health!
#Reproducibility #OpenScience
December 3, 2025 at 4:47 PM
We’ve contributed to open-source ECS software, including tools like fgbio and fastquorum, so this collaboration means a lot.
🔗https://github.com/fulcrumgenomics/fgbio
🔗https://github.com/nf-core/fastquorum
Standardization supports science and public health!
#Reproducibility #OpenScience
🔗https://github.com/fulcrumgenomics/fgbio
🔗https://github.com/nf-core/fastquorum
Standardization supports science and public health!
#Reproducibility #OpenScience
MutSeqR offers an R-based framework for ECS data analysis:
→ variant filtering
→ mutation frequency + dose-response modeling
→ benchmark dose estimation
→ spectrum + signature analysis
→ reproducible visualization tools
Openly available at 🔗 github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
→ variant filtering
→ mutation frequency + dose-response modeling
→ benchmark dose estimation
→ spectrum + signature analysis
→ reproducible visualization tools
Openly available at 🔗 github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
GitHub - EHSRB-BSRSE-Bioinformatics/MutSeqR: An R package for statistical analysis and visualization of mutation data.
An R package for statistical analysis and visualization of mutation data. - EHSRB-BSRSE-Bioinformatics/MutSeqR
github.com
December 3, 2025 at 4:47 PM
MutSeqR offers an R-based framework for ECS data analysis:
→ variant filtering
→ mutation frequency + dose-response modeling
→ benchmark dose estimation
→ spectrum + signature analysis
→ reproducible visualization tools
Openly available at 🔗 github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
→ variant filtering
→ mutation frequency + dose-response modeling
→ benchmark dose estimation
→ spectrum + signature analysis
→ reproducible visualization tools
Openly available at 🔗 github.com/EHSRB-BSRSE-Bioinformatics/MutSeqR
Error-corrected sequencing detects ultra-rare mutations, comparing multiple reads from both strands of an original DNA molecule and filtering away the noise. Used to study mutagenicity, chemical exposure, and disease mechanisms, until now analysis methods were fragmented across labs or proprietary.
December 3, 2025 at 4:46 PM
Error-corrected sequencing detects ultra-rare mutations, comparing multiple reads from both strands of an original DNA molecule and filtering away the noise. Used to study mutagenicity, chemical exposure, and disease mechanisms, until now analysis methods were fragmented across labs or proprietary.
Proud to share that our own Clint Valentine co-authored MutSeqR, an open-source R package for analyzing error-corrected sequencing (ECS) data.
Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research.
🔗 doi.org/10.1093/bioa...
#Genomics #OpenSource #MutSeqR 🧬🖥️
Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research.
🔗 doi.org/10.1093/bioa...
#Genomics #OpenSource #MutSeqR 🧬🖥️
December 3, 2025 at 4:41 PM
Proud to share that our own Clint Valentine co-authored MutSeqR, an open-source R package for analyzing error-corrected sequencing (ECS) data.
Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research.
🔗 doi.org/10.1093/bioa...
#Genomics #OpenSource #MutSeqR 🧬🖥️
Developed with Health Canada & U Ottawa, it helps bring consistency to genetic safety research.
🔗 doi.org/10.1093/bioa...
#Genomics #OpenSource #MutSeqR 🧬🖥️
The whole picture: How our values connect
Over the past weeks we shared our core values. If you followed this series, or worked with us as a client, collaborator, teammate, or friend, thank you. Today and every day we are thankful for you.
Read more here: blog.fulcrumgenomics.com/p/10th-anniv...
Over the past weeks we shared our core values. If you followed this series, or worked with us as a client, collaborator, teammate, or friend, thank you. Today and every day we are thankful for you.
Read more here: blog.fulcrumgenomics.com/p/10th-anniv...
10th Anniversary Core Values: The Intersection
How our values connect and guide us forward
blog.fulcrumgenomics.com
November 27, 2025 at 9:07 PM
The whole picture: How our values connect
Over the past weeks we shared our core values. If you followed this series, or worked with us as a client, collaborator, teammate, or friend, thank you. Today and every day we are thankful for you.
Read more here: blog.fulcrumgenomics.com/p/10th-anniv...
Over the past weeks we shared our core values. If you followed this series, or worked with us as a client, collaborator, teammate, or friend, thank you. Today and every day we are thankful for you.
Read more here: blog.fulcrumgenomics.com/p/10th-anniv...
At Fulcrum Genomics, Public Benefit isn’t just a principle, it's our purpose. Public Benefit has two levels, the commitment to working in biomedicine, and the daily acts of craftsmanship making the scientific ecosystem stronger. Both matter.
Read more here: blog.fulcrumgenomics.com/p/core-value...
Read more here: blog.fulcrumgenomics.com/p/core-value...
Core Value: Public Benefit
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
November 19, 2025 at 6:16 PM
At Fulcrum Genomics, Public Benefit isn’t just a principle, it's our purpose. Public Benefit has two levels, the commitment to working in biomedicine, and the daily acts of craftsmanship making the scientific ecosystem stronger. Both matter.
Read more here: blog.fulcrumgenomics.com/p/core-value...
Read more here: blog.fulcrumgenomics.com/p/core-value...
Some colleagues can to do everything and make it look effortless. This teammate reflects on balancing humility with confidence, and the power of giving your mind space to wander. By the end, you’ll feel like you’ve met us - or want to.
Meet Alison Meynert: blog.fulcrumgenomics.com/p/meet-aliso...
Meet Alison Meynert: blog.fulcrumgenomics.com/p/meet-aliso...
Meet Alison Meynert
Between the Lines of Code and Conversation
blog.fulcrumgenomics.com
November 12, 2025 at 6:14 PM
Some colleagues can to do everything and make it look effortless. This teammate reflects on balancing humility with confidence, and the power of giving your mind space to wander. By the end, you’ll feel like you’ve met us - or want to.
Meet Alison Meynert: blog.fulcrumgenomics.com/p/meet-aliso...
Meet Alison Meynert: blog.fulcrumgenomics.com/p/meet-aliso...
10th Anniversary Core Values blog series: Client Focus
Beyond just execution, we strive to understand the strategic context: What's the client's real need? What are the goals, constraints, and blind spots? How can we help them see around corners?
Read More: blog.fulcrumgenomics.com/p/core-value...
Beyond just execution, we strive to understand the strategic context: What's the client's real need? What are the goals, constraints, and blind spots? How can we help them see around corners?
Read More: blog.fulcrumgenomics.com/p/core-value...
Core Value: Client Focus
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
November 6, 2025 at 1:15 PM
10th Anniversary Core Values blog series: Client Focus
Beyond just execution, we strive to understand the strategic context: What's the client's real need? What are the goals, constraints, and blind spots? How can we help them see around corners?
Read More: blog.fulcrumgenomics.com/p/core-value...
Beyond just execution, we strive to understand the strategic context: What's the client's real need? What are the goals, constraints, and blind spots? How can we help them see around corners?
Read More: blog.fulcrumgenomics.com/p/core-value...
Today we feature a teammate whose way of thinking connects games and science. It’s that mix of strategy and lightness that makes working with him such a pleasure. By the end we hope you’ll feel like you’ve met us — or want to.
Meet Zach Norgaard: blog.fulcrumgenomics.com/p/meet-zach-...
Meet Zach Norgaard: blog.fulcrumgenomics.com/p/meet-zach-...
Meet Zach Norgaard
Seeing the Whole Board
blog.fulcrumgenomics.com
October 28, 2025 at 6:07 PM
Today we feature a teammate whose way of thinking connects games and science. It’s that mix of strategy and lightness that makes working with him such a pleasure. By the end we hope you’ll feel like you’ve met us — or want to.
Meet Zach Norgaard: blog.fulcrumgenomics.com/p/meet-zach-...
Meet Zach Norgaard: blog.fulcrumgenomics.com/p/meet-zach-...
10th Anniversary Core Values blog series: Valuing People
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Core Value: Valuing People
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
October 23, 2025 at 7:35 PM
10th Anniversary Core Values blog series: Valuing People
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
Valuing People is one of our deepest commitments: to ourselves, to our team, and to our clients. Life is messy—just like biology. When life gets complicated, we don’t look away. We step in.
Read More: blog.fulcrumgenomics.com/p/core-value...
The best part of our work is the people who make discovery possible — thoughtful, curious, and generous with their insight. In this series we hope you’ll feel like you’ve met us — or want to.
Meet Yossi Farjoun: blog.fulcrumgenomics.com/p/meet-yossi...
Meet Yossi Farjoun: blog.fulcrumgenomics.com/p/meet-yossi...
Meet Yossi Farjoun
Each Dataset a New Ascent
blog.fulcrumgenomics.com
October 15, 2025 at 7:05 PM
The best part of our work is the people who make discovery possible — thoughtful, curious, and generous with their insight. In this series we hope you’ll feel like you’ve met us — or want to.
Meet Yossi Farjoun: blog.fulcrumgenomics.com/p/meet-yossi...
Meet Yossi Farjoun: blog.fulcrumgenomics.com/p/meet-yossi...
@nilshomer.com , @tfenne.bsky.social , and Yossi Farjoun will be in Boston for #ASHG25.
If you're going to be there, let us know!
#ASHG2025
If you're going to be there, let us know!
#ASHG2025
October 8, 2025 at 3:22 PM
@nilshomer.com , @tfenne.bsky.social , and Yossi Farjoun will be in Boston for #ASHG25.
If you're going to be there, let us know!
#ASHG2025
If you're going to be there, let us know!
#ASHG2025
10th Anniversary Core Values blog series: Excellence
Excellence is a mindset and a practice. It’s not somewhere you arrive, but something you strive for, continually refining. It emerges from a culture of openness, curiosity, and accountability.
Read More: blog.fulcrumgenomics.com/p/core-value...
Excellence is a mindset and a practice. It’s not somewhere you arrive, but something you strive for, continually refining. It emerges from a culture of openness, curiosity, and accountability.
Read More: blog.fulcrumgenomics.com/p/core-value...
Core Value: Excellence
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
October 6, 2025 at 4:58 PM
10th Anniversary Core Values blog series: Excellence
Excellence is a mindset and a practice. It’s not somewhere you arrive, but something you strive for, continually refining. It emerges from a culture of openness, curiosity, and accountability.
Read More: blog.fulcrumgenomics.com/p/core-value...
Excellence is a mindset and a practice. It’s not somewhere you arrive, but something you strive for, continually refining. It emerges from a culture of openness, curiosity, and accountability.
Read More: blog.fulcrumgenomics.com/p/core-value...
10th Anniversary Core Values blog series: Openness
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Core Value: Openness
Fulcrum Genomics 10th Anniversary Series
blog.fulcrumgenomics.com
October 2, 2025 at 5:52 PM
10th Anniversary Core Values blog series: Openness
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
Openness is an action. It’s a positive, and proactive, choice to lean-in.
It begins with a simple but powerful question: What do I know that others need to know?
Read more: blog.fulcrumgenomics.com/p/core-value...
@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
September 25, 2025 at 9:39 AM
@nilshomer.com, Yossi Farjoun, and @tfenne.bsky.social will be attending #ASHG25 in Boston this year on behalf of Fulcrum Genomics. Let us know if you'll be there too!
Yesterday marked ten years since Fulcrum Genomics was founded. We took a moment to reflect:
blog.fulcrumgenomics.com/p/ten-years-...
Thanks to everyone who’s been part of the journey.
blog.fulcrumgenomics.com/p/ten-years-...
Thanks to everyone who’s been part of the journey.
July 28, 2025 at 6:23 PM
Yesterday marked ten years since Fulcrum Genomics was founded. We took a moment to reflect:
blog.fulcrumgenomics.com/p/ten-years-...
Thanks to everyone who’s been part of the journey.
blog.fulcrumgenomics.com/p/ten-years-...
Thanks to everyone who’s been part of the journey.
We love working with people who notice how things fit together, who make unwieldy problems work better. The 'Meet the Team' series spotlights humans behind our bioinformatics work. We hope you'll feel like you've met us — or want to. Meet Erin McAuley: blog.fulcrumgenomics.com/p/meet-erin-...
Meet Erin McAuley
Scaling Science Without Losing the Plot
blog.fulcrumgenomics.com
July 23, 2025 at 2:44 PM
We love working with people who notice how things fit together, who make unwieldy problems work better. The 'Meet the Team' series spotlights humans behind our bioinformatics work. We hope you'll feel like you've met us — or want to. Meet Erin McAuley: blog.fulcrumgenomics.com/p/meet-erin-...