Pietro Fratta
@frattalab.bsky.social
UCL Queen Square Institute of Neurology and The Francis Crick Institute. RNA metabolism and novel translational approaches for ALS/MND, Kennedy's disease and neurodegen.
Reposted by Pietro Fratta
Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model!
www.biorxiv.org/content/10.1...
@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social
www.biorxiv.org/content/10.1...
@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social
June 18, 2025 at 10:48 AM
Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model!
www.biorxiv.org/content/10.1...
@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social
www.biorxiv.org/content/10.1...
@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social
Reposted by Pietro Fratta
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 4:50 PM
A 🧵 to walk those interested through this paper...
Reposted by Pietro Fratta
Our new review on the challenges of modelling TDP-43 pathology in mice is just out:
rdcu.be/ejZ5a
As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.
rdcu.be/ejZ5a
As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.
Challenges of modelling TDP-43 pathology in mice
rdcu.be
April 30, 2025 at 4:20 PM
Our new review on the challenges of modelling TDP-43 pathology in mice is just out:
rdcu.be/ejZ5a
As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.
rdcu.be/ejZ5a
As usual, together with Lizzy Fisher. Thanks to Jose Brito and @lucastaoro.bsky.social from the lab for putting the data together for the comprehensive tables.
Something different from the lab!
We need better ALS biomarkers to minimise size, duration and cost of trials. Muscle MRI could work as it reliably detects progressive atrophy, and correlates with muscle strength loss.
@uclqsion.bsky.social @uclbrainscience.bsky.social
jnnp.bmj.com/content/earl...
We need better ALS biomarkers to minimise size, duration and cost of trials. Muscle MRI could work as it reliably detects progressive atrophy, and correlates with muscle strength loss.
@uclqsion.bsky.social @uclbrainscience.bsky.social
jnnp.bmj.com/content/earl...
Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis
Background and objectives Quantitative and operator-independent biomarkers of disease progression are urgently needed in amyotrophic lateral sclerosis (ALS) research. We assess the potential of skelet...
jnnp.bmj.com
April 6, 2025 at 10:10 AM
Something different from the lab!
We need better ALS biomarkers to minimise size, duration and cost of trials. Muscle MRI could work as it reliably detects progressive atrophy, and correlates with muscle strength loss.
@uclqsion.bsky.social @uclbrainscience.bsky.social
jnnp.bmj.com/content/earl...
We need better ALS biomarkers to minimise size, duration and cost of trials. Muscle MRI could work as it reliably detects progressive atrophy, and correlates with muscle strength loss.
@uclqsion.bsky.social @uclbrainscience.bsky.social
jnnp.bmj.com/content/earl...
Reposted by Pietro Fratta
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
TDP-43 pathology characterizes neurodegenerative diseases. Scialò et al. use in vitro-generated
and patient-derived TDP-43 aggregates as seeds to show that seed-induced TDP-43 cytoplasmic
aggregation ...
www.cell.com
March 28, 2025 at 3:15 PM
Happy to share our new study that was just published in Neuron! www.cell.com/neuron/fullt...