Frank Hause
@fhause.bsky.social
PhD student at Institute of Molecular Medicine at Martin Luther University Halle-Wittenberg (Hüttelmaier lab)
Molecular Biology | Complex Systems | Data Science | Bayesianism | Ordinary Language Theory | Liberal Democracy
Molecular Biology | Complex Systems | Data Science | Bayesianism | Ordinary Language Theory | Liberal Democracy
Reposted by Frank Hause
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
ngs-info.medizin.uni-halle.de
February 4, 2026 at 6:22 PM
Reposted by Frank Hause
We’d love to hear your thoughts. Tried CENTRA yet? Feedback, bugs, ideas, or a module that completely surprised you? Tell us, we’re already shaping the next updates.
💬 DMs are open, or visit ngs-info.medizin.uni-halle.de/shiny/CENTRA/ for more contact options.
💬 DMs are open, or visit ngs-info.medizin.uni-halle.de/shiny/CENTRA/ for more contact options.
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
ngs-info.medizin.uni-halle.de
February 4, 2026 at 6:21 PM
We’d love to hear your thoughts. Tried CENTRA yet? Feedback, bugs, ideas, or a module that completely surprised you? Tell us, we’re already shaping the next updates.
💬 DMs are open, or visit ngs-info.medizin.uni-halle.de/shiny/CENTRA/ for more contact options.
💬 DMs are open, or visit ngs-info.medizin.uni-halle.de/shiny/CENTRA/ for more contact options.
Reposted by Frank Hause
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
ngs-info.medizin.uni-halle.de
January 31, 2026 at 7:25 PM
Reposted by Frank Hause
Thinking about using CENTRA for functional exploration?
The browser comes with built-in functions to:
📚 parse gene metrics
🔍 generate ready-to-publish graphs
🧠 explore module functions across all networks
Everything is fully accessible without any account or login.
The browser comes with built-in functions to:
📚 parse gene metrics
🔍 generate ready-to-publish graphs
🧠 explore module functions across all networks
Everything is fully accessible without any account or login.
January 31, 2026 at 7:25 PM
Thinking about using CENTRA for functional exploration?
The browser comes with built-in functions to:
📚 parse gene metrics
🔍 generate ready-to-publish graphs
🧠 explore module functions across all networks
Everything is fully accessible without any account or login.
The browser comes with built-in functions to:
📚 parse gene metrics
🔍 generate ready-to-publish graphs
🧠 explore module functions across all networks
Everything is fully accessible without any account or login.
Reposted by Frank Hause
🔀 CENTRA assesses the variance of betweenness to see how stable a gene’s bridging role really is.
📉 By randomly rewiring our networks we control for underrepresented genes in the dataset.
🛡️ What remains are genuine, robust information brokers or hidden functional master regulators.
📉 By randomly rewiring our networks we control for underrepresented genes in the dataset.
🛡️ What remains are genuine, robust information brokers or hidden functional master regulators.
January 28, 2026 at 6:17 PM
🔀 CENTRA assesses the variance of betweenness to see how stable a gene’s bridging role really is.
📉 By randomly rewiring our networks we control for underrepresented genes in the dataset.
🛡️ What remains are genuine, robust information brokers or hidden functional master regulators.
📉 By randomly rewiring our networks we control for underrepresented genes in the dataset.
🛡️ What remains are genuine, robust information brokers or hidden functional master regulators.
Reposted by Frank Hause
👉 ngs-info.medizin.uni-halle.de/shiny/CENTRA/
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
🧪🧬🖥️ #AcademicSky #MedSky #CENTRA #MolecularBiology #Bioinformatics #NetworkBiology #SystemsBiology #GraphTheory #Centrality #FractalNetworks
CENTRA
Centrality-Based Exploration of Network Topologies from Regulatory Assemblies
ngs-info.medizin.uni-halle.de
January 25, 2026 at 3:06 PM
Reposted by Frank Hause
🧠 CENTRA uses Latent Dirichlet Allocation (LDA) to cluster gene sets by their semantic content.
🗂️ Each cluster becomes a distinct biological topic.
🕸️ This transforms unstructured text into functional gene networks.
🗂️ Each cluster becomes a distinct biological topic.
🕸️ This transforms unstructured text into functional gene networks.
January 25, 2026 at 3:06 PM
🧠 CENTRA uses Latent Dirichlet Allocation (LDA) to cluster gene sets by their semantic content.
🗂️ Each cluster becomes a distinct biological topic.
🕸️ This transforms unstructured text into functional gene networks.
🗂️ Each cluster becomes a distinct biological topic.
🕸️ This transforms unstructured text into functional gene networks.
Reposted by Frank Hause
Each gene in CENTRA comes with its own radar plot visualizing key topological properties:
📡 Centrality
🌿 Local fractality
🛡️ Robustness
Perfect for comparing genes across different biomedical topics.
📡 Centrality
🌿 Local fractality
🛡️ Robustness
Perfect for comparing genes across different biomedical topics.
January 22, 2026 at 7:14 PM
Each gene in CENTRA comes with its own radar plot visualizing key topological properties:
📡 Centrality
🌿 Local fractality
🛡️ Robustness
Perfect for comparing genes across different biomedical topics.
📡 Centrality
🌿 Local fractality
🛡️ Robustness
Perfect for comparing genes across different biomedical topics.
Reposted by Frank Hause
CENTRA’s topics span a wide biological landscape, including:
🧠 Neurodevelopment
🔬 DNA damage response
🦠 Immune regulation
💥 Apoptosis
🧫 Cancer metabolism
…besides many others. Each topic forms its own network with distinct functional hubs.
🧠 Neurodevelopment
🔬 DNA damage response
🦠 Immune regulation
💥 Apoptosis
🧫 Cancer metabolism
…besides many others. Each topic forms its own network with distinct functional hubs.
January 19, 2026 at 3:28 PM
CENTRA’s topics span a wide biological landscape, including:
🧠 Neurodevelopment
🔬 DNA damage response
🦠 Immune regulation
💥 Apoptosis
🧫 Cancer metabolism
…besides many others. Each topic forms its own network with distinct functional hubs.
🧠 Neurodevelopment
🔬 DNA damage response
🦠 Immune regulation
💥 Apoptosis
🧫 Cancer metabolism
…besides many others. Each topic forms its own network with distinct functional hubs.
Reposted by Frank Hause
🧩 CENTRA identifies modules using Louvain clustering.
🔍 Each module is tested for functional coherence via Overrepresentation Analysis.
📊 The resulting modules often align with coordinated biological processes and pathways.
🔍 Each module is tested for functional coherence via Overrepresentation Analysis.
📊 The resulting modules often align with coordinated biological processes and pathways.
January 16, 2026 at 5:58 PM
🧩 CENTRA identifies modules using Louvain clustering.
🔍 Each module is tested for functional coherence via Overrepresentation Analysis.
📊 The resulting modules often align with coordinated biological processes and pathways.
🔍 Each module is tested for functional coherence via Overrepresentation Analysis.
📊 The resulting modules often align with coordinated biological processes and pathways.
Reposted by Frank Hause
🌿 Some genes reveal structure not by connections alone, but by how complex their local neighborhood is.
CENTRA uses Local Fractal Dimension to capture this, a measure of how dense the surroundings of a gene become in the network.
✨ High LFD can hint at elevated information density.
CENTRA uses Local Fractal Dimension to capture this, a measure of how dense the surroundings of a gene become in the network.
✨ High LFD can hint at elevated information density.
January 13, 2026 at 6:22 PM
🌿 Some genes reveal structure not by connections alone, but by how complex their local neighborhood is.
CENTRA uses Local Fractal Dimension to capture this, a measure of how dense the surroundings of a gene become in the network.
✨ High LFD can hint at elevated information density.
CENTRA uses Local Fractal Dimension to capture this, a measure of how dense the surroundings of a gene become in the network.
✨ High LFD can hint at elevated information density.
Reposted by Frank Hause
⭐ Some genes stand out because of who they’re connected to.
CENTRA uses eigenvector centrality to identify these influence hubs, genes linked to other highly connected players across the network.
✨ High eigenvector values can hint at strong regulatory relevance.
CENTRA uses eigenvector centrality to identify these influence hubs, genes linked to other highly connected players across the network.
✨ High eigenvector values can hint at strong regulatory relevance.
January 12, 2026 at 3:12 PM
⭐ Some genes stand out because of who they’re connected to.
CENTRA uses eigenvector centrality to identify these influence hubs, genes linked to other highly connected players across the network.
✨ High eigenvector values can hint at strong regulatory relevance.
CENTRA uses eigenvector centrality to identify these influence hubs, genes linked to other highly connected players across the network.
✨ High eigenvector values can hint at strong regulatory relevance.
Reposted by Frank Hause
🔀 Some genes quietly sit at the crossroads of biological information flow.
CENTRA uses betweenness centrality to find these hidden mediators, genes that bridge modules and shape how information moves through a network.
✨ High betweenness can hint at regulatory leverage.
CENTRA uses betweenness centrality to find these hidden mediators, genes that bridge modules and shape how information moves through a network.
✨ High betweenness can hint at regulatory leverage.
January 11, 2026 at 9:28 PM
🔀 Some genes quietly sit at the crossroads of biological information flow.
CENTRA uses betweenness centrality to find these hidden mediators, genes that bridge modules and shape how information moves through a network.
✨ High betweenness can hint at regulatory leverage.
CENTRA uses betweenness centrality to find these hidden mediators, genes that bridge modules and shape how information moves through a network.
✨ High betweenness can hint at regulatory leverage.
Reposted by Frank Hause
How do we define a key gene in a network?
CENTRA uses multiple centrality measures:
🔹 Betweenness
🔹 Eigenvector
🔹 Local Fractal Dimension
These combine to reveal functional importance across contexts.
CENTRA uses multiple centrality measures:
🔹 Betweenness
🔹 Eigenvector
🔹 Local Fractal Dimension
These combine to reveal functional importance across contexts.
January 10, 2026 at 6:44 PM
How do we define a key gene in a network?
CENTRA uses multiple centrality measures:
🔹 Betweenness
🔹 Eigenvector
🔹 Local Fractal Dimension
These combine to reveal functional importance across contexts.
CENTRA uses multiple centrality measures:
🔹 Betweenness
🔹 Eigenvector
🔹 Local Fractal Dimension
These combine to reveal functional importance across contexts.
Reposted by Frank Hause
CENTRA is available as interactive browser app:
🧭 Explore topic-specific networks
🔍 Search genes or terms
🌐 Visualize modules, metrics, enrichments
🧭 Explore topic-specific networks
🔍 Search genes or terms
🌐 Visualize modules, metrics, enrichments
January 9, 2026 at 6:45 PM
CENTRA is available as interactive browser app:
🧭 Explore topic-specific networks
🔍 Search genes or terms
🌐 Visualize modules, metrics, enrichments
🧭 Explore topic-specific networks
🔍 Search genes or terms
🌐 Visualize modules, metrics, enrichments
Reposted by Frank Hause
🚨 Our CENTRA paper is out in NAR Genomics and Bioinformatics!
CENTRA shows how centrality and fractal geometry uncover functional master regulators across biological networks. You can explore everything instantly, completely open access.
doi.org/10.1093/narg...
CENTRA shows how centrality and fractal geometry uncover functional master regulators across biological networks. You can explore everything instantly, completely open access.
doi.org/10.1093/narg...
Validate User
doi.org
January 7, 2026 at 8:35 AM
🚨 Our CENTRA paper is out in NAR Genomics and Bioinformatics!
CENTRA shows how centrality and fractal geometry uncover functional master regulators across biological networks. You can explore everything instantly, completely open access.
doi.org/10.1093/narg...
CENTRA shows how centrality and fractal geometry uncover functional master regulators across biological networks. You can explore everything instantly, completely open access.
doi.org/10.1093/narg...
Reposted by Frank Hause
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 8, 2025 at 6:02 AM
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
Reposted by Frank Hause
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Frank Hause
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
embl.wd103.myworkdayjobs.com
October 10, 2025 at 7:30 AM
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Frank Hause
Auch hier ist nicht drin was drauf steht. Verbieten!
October 8, 2025 at 5:36 PM
Auch hier ist nicht drin was drauf steht. Verbieten!
Reposted by Frank Hause
🚨 Two manuscripts accepted at Nature Communications within one week!🎉 Both papers deal with GPCRs. Thank you, Anette Kaiser and Tobi Langenhan, the wonderful collaborations! 😀 More details will follow. @unihalle.bsky.social @unileipzig.bsky.social
August 29, 2025 at 10:50 AM
🚨 Two manuscripts accepted at Nature Communications within one week!🎉 Both papers deal with GPCRs. Thank you, Anette Kaiser and Tobi Langenhan, the wonderful collaborations! 😀 More details will follow. @unihalle.bsky.social @unileipzig.bsky.social
Reposted by Frank Hause
🧪 And this is the second Nature Communications @natcomms.nature.com paper where we contributed:
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social
October 5, 2025 at 8:05 AM
🧪 And this is the second Nature Communications @natcomms.nature.com paper where we contributed:
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social
www.nature.com/articles/s41...
@academic-chatter.bsky.social @academicsky.org #teammassspec
@unileipzig.bsky.social @unihalle.bsky.social
Reposted by Frank Hause
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
October 3, 2025 at 9:10 AM
Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇
The gentle rays of morning hint at summer’s end.
October 2, 2025 at 9:16 AM
The gentle rays of morning hint at summer’s end.