Frederickson D. Entila, PhD
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fdentila.bsky.social
Frederickson D. Entila, PhD
@fdentila.bsky.social
peeking through immunity dependencies of plant-microbiota dialogues…
Researcher IRRI
PhD MPIPZ
Post-Doc MPIPZ
functional overlap among organ microbiota doesn’t seem to apply for trees as what we usually see in other relatively smaller plants; the internal tissues of trees are so anoxic, nutritionally restrictive, and antimicrobial-rich analogous to mammalian stomach…

www.nature.com/articles/s41...
A diverse and distinct microbiome inside living trees - Nature
Microbiome analyses of living trees show that a single tree can host approximately one trillion bacteria, with microbial communities distinctly partitioned between heartwood and sapwood and with minim...
www.nature.com
August 15, 2025 at 6:05 AM
even the sight of sick people elicits immune responses as an anticipation for a possible infection…

www.nature.com/articles/s41...
Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience
Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...
www.nature.com
July 30, 2025 at 6:35 AM
Reposted by Frederickson D. Entila, PhD
We present MetaFlowTrain, an easy-to-build, highly parallelized, and cost-effective fluidic system for studying microbial exometabolites and their roles in modulating microbe–microbe–host interactions. Kudos to @chesneau-g.bsky.social @mpipz.bsky.social
Give it a try: www.nature.com/articles/s41...
April 10, 2025 at 9:59 AM
Reposted by Frederickson D. Entila, PhD
Finally!
Im so excited to present to culmination of many years of work from the fantastic Defeng Shen and some great collaborators. For details, I have made a digested thread below, but if you are more interested feel free to reach out (and read the paper of course).
www.science.org/doi/10.1126/...
Apoplastic barriers are essential for nodule formation and nitrogen fixation in Lotus japonicus
Establishment of the apoplastic root barrier known as the Casparian strip occurs early in root development. In legumes, this area overlaps with nitrogen-fixing nodule formation, which raises the possi...
www.science.org
March 21, 2025 at 5:53 AM
viral coat protein is perceived by RBRL, enhancing its ligase activity to ubiquitinate NINJA3 for degradation leading to de-repression of JA signalling for antiviral defense in rice

www.nature.com/articles/s41...
Perception of viral infections and initiation of antiviral defence in rice - Nature
Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.
www.nature.com
March 18, 2025 at 5:12 PM
the mycorrhizal highways moves in waves with trade interests at the forefront flowing dynamically in both ways within hyphae.

www.nature.com/articles/s41...
A travelling-wave strategy for plant–fungal trade - Nature
Symbiotic fungi control network-level structure and flows to meet trade demands.
www.nature.com
February 26, 2025 at 7:40 PM
www.science.org/doi/10.1126/...
gut microbiota represses lncRNA Snhg9 expression in the intestine to reconfigure lipid metabolism abetting diet-induced obesity in mice.
The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9
The intestinal microbiota promotes lipid absorption and storage by repressing the expression of the long noncoding RNA gene Snhg9.
www.science.org
February 12, 2025 at 2:26 PM
cancer cells transfer ROS-resistant defective mitochondria to immune cells rendering it dysfunctional, senescent, and memory deficient to evade immunity…

www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 25, 2025 at 10:34 AM
expanded bioluminescence spectrum for simultaneous imaging of cellular processes, even with just a smartphone

www.science.org/doi/10.1126/...
Creating coveted bioluminescence colors for simultaneous multi-color bioimaging
Twenty-color bioluminescent proteins have been developed for simultaneous imaging of multiple biological targets.
www.science.org
January 25, 2025 at 10:04 AM
The siderophore coelichelin from Streptomyces sp. sensitizes the competitor Bacillus subtilis to phage predation via iron-sequestration resulting to inhibition of Spo0A activation.

www.nature.com/articles/s41...
Streptomyces secretes a siderophore that sensitizes competitor bacteria to phage infection - Nature Microbiology
A secondary metabolite sensitizes competitor Bacillus subtilis to a wide panel of lytic phages by sequestering iron and preventing the activation of Spo0A.
www.nature.com
January 18, 2025 at 10:16 AM
sequence-to-ecology study of Pseudomonas siderophores reveal microbial iron heist: non-pathogenic strains are iron altruists while pathogenic strains are selfish iron hoarders.

www.science.org/doi/10.1126/...
Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks
Coevolving siderophore genes shape bacterial iron networks, unveiling the complexity of cheating across habitats and lifestyles.
www.science.org
January 16, 2025 at 10:28 AM
Reposted by Frederickson D. Entila, PhD
New year, new paper! Now published in @nature.com. We identified and characterised diverse immune cell states in plants under pathogen attack. My postdoc work in the Ecker lab at @salkinstitute.bsky.social. A thread (0/n)
#PlantScience
www.nature.com/articles/s41...
January 8, 2025 at 4:27 PM
onlinelibrary.wiley.com/doi/abs/10.1...
Here we review the mechanistic relevance of innate immunity in orchestrating plant-microbiota dialogues and discuss the pluses and perils of microbiota. Also, we highlighted the role of host immunity in regulating the potentially pathogenic microbiota members.
Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members
Plants are in intimate association with taxonomically defined microbiota. In here we review recent literature regarding the crucial role of plant immunity in controlling the potentially pathogenic me....
onlinelibrary.wiley.com
December 14, 2024 at 11:27 AM